Zanocin Liquid (Ofloxacin) Used to Treat Various Bacterial Infection in Children

Product Overview

Zanocin Liquid (Ofloxacin) is a broad-spectrum fluoroquinolone antibiotic used in the treatment of various bacterial infections including respiratory infections such as pneumonia and bronchitis, urinary tract infections, skin infections, and infections of the genital organs. Zanocin Liquid is a broad-spectrum fluoroquinolone antibiotic containing Ofloxaxin. It is a potent antimicrobial agent formulated for the treatment of various bacterial infections by targeting the DNA replication process of the invading pathogens. As a second-generation fluoroquinolone, Zanocin is highly effective against a wide range of Gram-positive and Gram-negative bacteria. This liquid formulation is particularly useful for patients who have difficulty swallowing tablets, such as pediatric or geriatric populations, ensuring accurate dosing and rapid systemic absorption.

Product Composition

• Active Ingredient: Ofloxacin (typically 50 mg or 100 mg per 5 ml)
• Sweetening Agents: Sucrose or Sorbitol to improve palatability for oral administration
• Flavoring Agents: Often contains fruit-based flavors (e.g., orange or peppermint) to mask the bitter taste of the antibiotic
• Preservatives: Methylparaben and Propylparaben to maintain microbial stability
• Solvents: Purified Water and Glycerin
• Buffering Agents: Sodium Citrate or Citric Acid to maintain optimal pH levels

Product Specification

Mechanism of Action

• Inhibition of DNA Gyrase: Ofloxacin inhibits the enzyme DNA gyrase (Topoisomerase II), which is essential for the replication, transcription, and repair of bacterial DNA.
• Topoisomerase IV Targeting: In many Gram-positive bacteria, it specifically targets Topoisomerase IV, interfering with the separation of replicated chromosomal DNA during cell division.
• Bactericidal Effect: By creating irreversible damage to the bacterial DNA structure, the medication causes rapid bacterial cell death rather than just inhibiting growth.
• High Tissue Penetration: The molecular structure allows for excellent distribution across various body tissues and fluids, including the lungs, skin, and urinary tract.
• Concentration-Dependent Killing: The efficacy is largely dependent on the peak concentration reached in the body relative to the minimum inhibitory concentration (MIC) for the specific pathogen.

Key Benefits

• Broad Antimicrobial Coverage: Effective against a diverse array of pathogens, reducing the need for multiple antibiotics in mixed infections.
• Ease of Administration: The liquid format allows for precise dose adjustments based on body weight, which is critical in pediatric care.
• Rapid Absorption: Ofloxacin is quickly and well-absorbed from the gastrointestinal tract, leading to high bioavailability.
• Twice-Daily Dosing: The pharmacokinetic profile typically allows for a convenient 12-hour dosing interval.
• Stable Liquid Base: Formulated to remain stable and effective throughout the prescribed course of treatment when stored correctly.