Asklerol 2ml Injection (Polidocanol 3%) | Used to Treat Small Varicose, Spider, and Reticular Veins
Asklerol 2ml Injection (Polidocanol 3%) is a sclerosing agent used in the treatment of varicose veins and spider veins by injecting directly into the affected vein. Works by damaging the inner lining of the blood vessel, causing it to swell, stick together, and eventually collapse and be absorbed by the body, redirecting blood flow to healthier veins.
Product Overview
Asklerol 2ml Injection is a specialized sclerosing agent containing Polidocanol (3%), primarily used for the non-surgical treatment of varicose veins and hemorrhoids. As a high-performance sclerosant, it is designed to eliminate damaged veins by inducing localized controlled injury to the vessel wall, leading to its eventual closure and disappearance. This minimally invasive intervention offers a cosmetic and therapeutic solution for vascular disorders, providing a clear alternative to traditional surgical vein stripping.
Product Composition
- Polidocanol (30mg per ml): The active medicinal ingredient, which acts as a detergent-type sclerosing agent with dual properties as a local anesthetic and a surfactant.
- Ethanol (96%): Included in the formulation to maintain the solubility and stability of the active compound.
- Potassium Dihydrogen Phosphate: Acts as a buffering agent to ensure the pH of the solution is compatible with human tissue.
- Water for Injection: The sterile vehicle used to deliver the precise 3% concentration required for large-vessel sclerotherapy.
Product Specification
| Feature | Specification Details |
| Therapeutic Class | Sclerosing Agent / Vasosclerosant |
| Active Ingredient | Polidocanol |
| Concentration | 3% (60mg per 2ml ampoule) |
| Dosage Form | Solution for Injection |
| Primary Indication | Varicose Veins and Telangiectasias |
Mechanism of Action
- Endothelial Damage: Upon injection, Polidocanol disrupts the lipid bilayer of the endothelial cells lining the vein, causing immediate localized damage.
- Vessel Fibrosis: The resulting irritation triggers a localized inflammatory response, which leads to the formation of a thrombotic occlusion (a controlled clot) within the vessel.
- Venous Obliteration: Over time, the treated vein is replaced by fibrous connective tissue, effectively removing it from the circulatory path.
- Dual Anesthetic Effect: Uniquely, Polidocanol possesses local anesthetic properties, which significantly reduces the pain and discomfort typically felt at the injection site during the procedure.
Key Benefits
- Minimally Invasive: Offers a highly effective office-based procedure for vein removal, requiring no general anesthesia or significant downtime.
- Superior Aesthetic Results: Effectively eliminates the appearance of spider veins and reticular veins, restoring the natural look of the skin.
- High Success Rate: Provides a permanent solution for treated vessels, with a very low rate of vein recanalization when administered correctly.
- Improved Hemorrhoidal Care: Acts as a reliable treatment for Grade I and II internal hemorrhoids, reducing bleeding and prolapse symptoms.
- Reduced Patient Discomfort: Because it numbs the area while working, it is generally better tolerated by patients compared to other vasosclerosants like sodium tetradecyl sulfate.
Precautions
Important Precautions Before Using Asklerol 2ml Injection (Polidocanol 3%)
Asklerol Injection contains Polidocanol and is used for sclerotherapy in varicose veins and spider veins. It should be used only under proper medical supervision.
| Condition or Situation | Precaution |
|---|---|
| Allergy to Polidocanol | Avoid use if you have known hypersensitivity |
| Pregnancy | Use only if clearly necessary after evaluation |
| Breastfeeding | Use with caution and medical advice |
| Blood clot disorders | May require careful assessment before use |
| Severe vein blockage | Not suitable in some advanced vascular conditions |
| Heart or lung disease | Use with caution due to risk of complications |
| Skin infections at injection site | Treatment should be postponed |
Important Things to Remember
- Must be administered only by a trained professional
- Follow post procedure care instructions strictly
- Avoid strenuous activity immediately after treatment
- Wear compression stockings if advised
- Report pain, swelling, or discoloration at injection site
- Do not ignore signs of allergic reaction
Extra Care Required
Patients with vascular disease, clotting issues, or severe circulation problems may need careful evaluation before undergoing treatment with Asklerol Injection. Regular follow up is important for safe outcomes.
Usage
Asklerol 2ml Injection must be administered exclusively by a trained healthcare professional, typically a vascular surgeon or dermatologist, in a clinical setting. The injection technique—whether used as a liquid or converted into a foam—is determined by the size and location of the target vessel. Proper post-treatment compression is a critical factor in ensuring the vein remains closed and heals correctly.
Injection Technique: The solution is injected directly into the lumen of the affected vein. For larger varicose veins, the 3% concentration is often converted into a sclerosing foam by mixing it with air or a physiological gas to increase the contact area with the vessel wall.
Needle Precision: Fine-gauge needles or catheters are used to ensure the sclerosant is delivered precisely, often under ultrasound guidance to map deeper venous structures.
Compression Therapy: Immediately following the injection, a compression bandage or medical-grade stocking is applied to the limb. This pressure is essential to prevent blood from re-entering the treated vein and to facilitate fibrous transformation.
Patient Mobility: Patients are typically encouraged to walk for 15–30 minutes immediately after the procedure to promote deep venous circulation and prevent the formation of unwanted clots.
Dosage Limits: The total volume of Asklerol administered in a single session is strictly limited based on the patient's body weight to maintain a high safety profile.
Uses
| Indication | Description of Application |
| Large Varicose Veins | Used for the obliteration of medium to large tributary veins in the legs. |
| Internal Hemorrhoids | Administered as a submucosal injection to treat Grade I and II hemorrhoids by inducing shrinkage. |
| Reticular Veins | Targets the "blue" feeder veins that often lead to the formation of smaller spider veins. |
| Recurrent Varicosities | Provides a solution for veins that appear after a previous surgical stripping or laser treatment. |
| Esophageal Varices | In specialized gastroenterology, used to stop bleeding in swollen esophageal veins. |
Targeted Therapeutic Applications
Ultrasound-Guided Sclerotherapy (UGFS): Allows for the non-surgical treatment of incompetent veins that are not visible to the naked eye.
Foam Sclerotherapy: Utilizing the "Tessari technique" to create a microfoam that displaces blood, ensuring maximum endothelial contact in larger vessels.
Spider Vein Eradication: Though 3% is a high concentration, it is sometimes used for resistant telangiectasias when lower concentrations have failed.
Symptomatic Relief: Alleviates the "heavy leg" feeling, aching, and nocturnal cramping associated with chronic venous insufficiency.
Hemorrhoidal Hemostasis: Rapidly stops chronic bleeding from internal hemorrhoids by promoting localized fibrosis of the vascular cushions.
Side Effects
Possible Side Effects of Asklerol 2ml Injection (Polidocanol 3%)
Asklerol Injection may cause side effects at or near the injection site. Most effects are mild and temporary, but some may require medical attention.
Common Side Effects
- Pain or burning at injection site
- Mild redness
- Swelling
- Bruising
- Itching
- Temporary skin discoloration
Less Common Side Effects
- Local inflammation
- Hardening of treated vein
- Mild numbness near injection area
- Small skin ulcers
- Headache
- Dizziness
| Rare Side Effects | Details |
|---|---|
| Severe allergic reaction | Rash, swelling, or breathing difficulty |
| Skin necrosis | Tissue damage around injection site |
| Deep vein thrombosis | Blood clot formation in deep veins |
| Severe pigmentation changes | Long lasting skin darkening |
| Visual disturbances | Rare temporary vision issues after injection |
When to Seek Medical Attention
Seek immediate medical help if you notice severe pain, signs of infection, breathing difficulty, or symptoms of blood clots. Persistent skin changes should also be evaluated by a healthcare professional.
FAQs
Q: What is Asklerol Injection?
A: Asklerol Injection contains Polidocanol 3%, a sclerosing agent used to treat varicose veins and spider veins. It is injected directly into the affected vein as part of a procedure known as sclerotherapy, performed by a trained healthcare professional.
Q: What is the product used for?
A: Asklerol Injection is used to treat small to medium sized varicose veins and telangiectasias (spider veins) for both cosmetic and therapeutic purposes. It helps relieve symptoms such as pain, heaviness, swelling, and discomfort associated with varicose veins.
Q: How does it work?
A: Polidocanol damages the inner lining of the blood vessel wall, causing it to swell and stick together. The vein then collapses, is sealed shut, and is gradually absorbed by the body over time. Blood flow is naturally redirected to healthier surrounding veins.
Q: How is it administered?
A: Asklerol is injected directly into the affected vein using a fine needle by a trained healthcare professional. The number of injections and the amount used depends on the size, number, and location of the veins being treated.
Q: How many sessions are needed?
A: The number of sessions required depends on the extent and severity of the varicose or spider veins. Some patients may see results after one session while others may require multiple sessions spaced several weeks apart. The doctor will determine the appropriate treatment plan.
Q: How long does it take to see results?
A: Small spider veins may fade within 3 to 6 weeks after treatment. Larger varicose veins may take 3 to 4 months to respond fully. In some cases the treated vein may appear darker or more prominent initially before gradually fading.
Q: Is the procedure painful?
A: Most patients experience only mild discomfort, burning, or stinging at the injection site during the procedure. Polidocanol also has a mild local anesthetic effect which helps minimize pain during injection.
Q: Who should not use it?
A: Asklerol Injection should not be used in patients with a known allergy to Polidocanol, severe arterial disease, uncontrolled diabetes, active blood clots or deep vein thrombosis, severe heart or lung conditions, or those who are pregnant or bedridden. Consult your doctor to determine suitability.
Q: What are the common side effects?
A: Common side effects include temporary bruising, redness, swelling, and mild pain at the injection site. Brown pigmentation or darkening of the skin over the treated vein may occur and usually fades over time. Rarely, allergic reactions or blood clots may occur.
Q: Can it cause skin discoloration?
A: Yes, temporary brown pigmentation or skin darkening over the treated area is a known side effect. This is caused by iron deposits from the destroyed red blood cells and usually fades within a few months but in some cases may take longer.
Q: What precautions should be taken after the procedure?
A: Patients are usually advised to wear compression stockings for a period after treatment, avoid prolonged sitting or standing, take regular short walks to improve circulation, avoid hot baths, saunas, and direct sunlight on the treated area, and avoid strenuous exercise for a short period as advised by the doctor.
Q: Is it safe during pregnancy or breastfeeding?
A: Asklerol Injection is not recommended during pregnancy. For breastfeeding mothers, it is advisable to avoid breastfeeding for at least 2 days after the procedure.
Q: Can varicose veins return after treatment?
A: Sclerotherapy effectively treats existing varicose and spider veins but does not prevent new ones from forming. Maintaining a healthy weight, regular exercise, wearing compression stockings, and avoiding prolonged standing or sitting can help reduce the risk of new veins developing.
Interactions
Drug Interactions of Asklerol 2ml Injection (Polidocanol 3%)
Asklerol Injection contains Polidocanol and is used for sclerotherapy. It may interact with certain medicines or conditions that affect blood clotting and circulation.
| Medicine or Substance | Possible Interaction |
|---|---|
| Anticoagulants (blood thinners) | May increase risk of bleeding or bruising |
| Antiplatelet drugs | Can increase injection site bleeding risk |
| Other sclerotherapy agents | May increase local tissue reaction |
| Local anesthetics | May enhance or alter local effects |
| Corticosteroids | May affect healing response in some cases |
| Alcohol | May worsen bruising and delay healing |
Important Things to Keep in Mind
- Inform about all medicines before the procedure
- Include supplements and herbal products
- Avoid blood thinners if advised before treatment
- Follow post procedure instructions carefully
- Report unusual swelling, pain, or skin discoloration
Health Related Interactions
Patients with clotting disorders, severe venous disease, or poor circulation may have increased risk of complications and should be carefully evaluated before treatment with Asklerol Injection.
| Manufacturer | : | Samarth Life Sciences Pvt Ltd |
| Trade Name | : | Asclera |
| Generic Search | : | Asklerol |
| Strength | : | 2 ml Inj. |
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