Renvela Tablet (Sevelamer)

What is Sevelamer Tablet?

Sevelamer is a phosphate binder. Sevelamer helps prevent hypocalcemia (low levels of calcium in the body) caused by elevated phosphorus. Sevelamer is used to control phosphorus levels in people with chronic kidney disease who are on dialysis. Sevelamer may also be used for purposes not listed in this medication guide.

Sevelamer Tablet, also known as Renvela, is generally considered safe for use. However, it is crucial to consult with a healthcare professional before starting any medication. They can assess your medical history, evaluate potential risks and benefits, and provide personalized advice regarding the use of Sevelamer Tablet. Always follow the prescribed dosage and any additional instructions given by your healthcare provider to ensure your safety and well-being.

Uses of Renvela Tablet (Sevelamer)

Renvela Tablet (Sevelamer) is primarily used to lower phosphate levels in the blood of individuals with chronic kidney disease (CKD) who are on dialysis. It works by binding to phosphate in the digestive tract, preventing its absorption into the bloodstream. High phosphate levels in CKD patients can lead to complications such as bone problems and mineral imbalances. By controlling phosphate levels, Renvela Tablet helps in the management of these conditions and supports overall kidney health. It is important to note that Renvela Tablet should be used as part of a comprehensive treatment plan that includes dietary restrictions and other medications as prescribed by a healthcare professional.

Sevelamer Dosing Information

Usual Adult Dose for Hyperphosphatemia of Renal Failure:

Initial Dosing for patients not on a phosphate binder: 800 mg to 1600 mg orally 3 times a day with meals
Based on serum phosphorus level:
-Phosphorus greater than 5.5 to less than 7.5 mg/dL: 800 mg 3 times a day with meals
-Phosphorus greater than or equal to 7.5 mg/dL: 1600 mg 3 times a day with meals
-Titrate in increments of 800 mg 3 times a day at 2-week intervals with the goal of controlling serum phosphorus within the target range.
Average prescribed dose: 7.2 g/day (2.4 g with each meal)
Maximum studied dose: 14 g per day (carbonate); 13 g per day (hydrochloride)

Switching from the hydrochloride salt to carbonate: Use the same dose, however further titration may be necessary to achieve desired phosphorus levels.

Switching from calcium acetate: Substitute approximately mg for mg

Comment: Treatment of hyperphosphatemia includes a reduction in dietary intake of phosphate, inhibition of intestinal phosphate absorption with phosphate binders, and removal of phosphate with dialysis.

Use: To control serum phosphorus levels in patients with chronic kidney disease on dialysis.

What is the most important information I should know about sevelamer?

You should not take this medicine if you have a bowel obstruction.

What should I discuss with my healthcare provider before taking Sevelamer?

You should not take sevelamer if you are allergic to it, or if you have a bowel obstruction. To make sure sevelamer is safe for you, tell your doctor if you have: trouble swallowing; severe constipation; a blockage in your intestines; slow digestion; a stomach or intestinal disorder; or if you have recently had stomach or intestinal surgery. It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. Your dose needs may be different during pregnancy. Taking sevelamer while you are pregnant can lower your blood levels of certain vitamins or folic acid. Follow your doctor's instructions about taking vitamins or mineral supplements during pregnancy. Because sevelamer is not absorbed into the bloodstream, it is not expected to be harmful to a nursing baby. Sevelamer is not approved for use by anyone younger than 6 years old.

How should I take sevelamer?

Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use this medicine in larger or smaller amounts or for longer than recommended. Take sevelamer with meals. Sevelamer powder must be dissolved in water before you take it. The 0.8-gram packet should be mixed with at least 1 ounce (2 tablespoons) of water. The 2.4-gram packet should be mixed with at least 2 ounces (4 tablespoons) of water. Stir the powder in water until it is completely dissolved. Stir and drink this mixture right away. To get the entire dose, add a little more water to the same glass, swirl gently, and drink right away.

While using sevelamer, you may need frequent blood tests. Call your doctor if you have trouble swallowing the tablet, or if it feels like it gets stuck in your esophagus after you swallow it. Sevelamer may be only part of a complete program of treatment that also includes a special diet. It is very important to follow the diet plan created for you by your doctor or nutrition counselor. You should become very familiar with the list of foods you must eat or avoid to help control your condition. Store at room temperature away from moisture and heat.

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What happens if I miss a dose?

Take the missed dose as soon as you remember. Be sure to take the missed dose with food. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up for the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking sevelamer?

You may be taking other medicines that should not be taken at the same time. Taking sevelamer can make it harder for your body to absorb certain drugs, making them less effective: ciprofloxacin (Cipro) should be taken at least 2 hours before or 6 hours after you take sevelamer; mycophenolate mofetil (CellCept) should be taken at least 2 hours before you take sevelamer.

Sevelamer Tablet Side Effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using sevelamer and call your doctor at once if you have: choking, or trouble swallowing; black, bloody, or tarry stools; severe constipation with stomach pain; or constipation that gets worse or does not clear up.

Common side effects may include nausea, vomiting, stomach pain, loss of appetite; upset stomach, gas, bloating; diarrhea, constipation; tired feeling; itching; or joint pain.

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Drug Interaction with Renvela Tablet (Sevelamer)

Renvela Tablet (Sevelamer) may interact with certain medications, so it is important to inform your healthcare provider about all the medications you are taking. Some drugs that may interact with Renvela include antibiotics like ciprofloxacin and moxifloxacin, antacids containing aluminum or magnesium, and certain seizure medications such as phenytoin and carbamazepine. These interactions can affect the absorption and effectiveness of both Renvela and the interacting medications. Your healthcare provider can provide guidance on how to manage these interactions, which may involve adjusting the timing of doses or considering alternative medications. It is crucial to follow their advice to ensure the safe and effective use of the Renvela Tablet.

FAQs:

Q: Can Renvela Tablet be crushed or chewed?

A: Renvela Tablet should not be crushed or chewed. It is designed to be swallowed whole. If you have difficulty swallowing the tablet, talk to your doctor about alternative options.

Q: Are there any dietary restrictions while taking Renvela Tablet?

A: Renvela Tablet should be taken with meals. Your healthcare provider may also recommend certain dietary modifications, such as limiting the intake of foods high in phosphate, to help manage your phosphate levels. Follow their advice for the best results.

Q: Can I breastfeed while taking Renvela Tablet?

A: It is not known whether Renvela Tablet passes into breast milk. Talk to your healthcare provider to assess the potential risks and benefits before taking this medication while breastfeeding.