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  1. Generic: Isotretinoin
    Equivalent Brand: Accutane
    30 Capsule/s
  2. Generic: Isotretinoin
    Equivalent Brand: Accutane
    30 Tablet/s
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This medication is employed to treat severe cystic acne (also referred to as nodular acne) that has not skilled other treatments (e.g., peroxide or clindamycin applied to the skin or tetracycline or minocycline taken by mouth). It belongs to a category of medicine referred to as retinoids. It works by decreasing facial oil (sebum) production. High amounts of sebum can cause severe acne. If left untreated, severe acne may cause permanent scarring.

How to use

  • Read the Medication Guide provided by your pharmacist before you begin using isotretinoin and every time you get a refill. Read and sign a Patient Information/Informed Consent form before you start taking this medication. If you've got any questions on isotretinoin, consult your doctor or pharmacist before taking the medication.
  • Swallow the capsules whole. Do not crush or chew them. Isotretinoin is typically taken twice daily for 15-20 weeks, or as directed by your doctor. Directions for many generic sorts of isotretinoin state that it should be crazy meals. However, the FDA has indicated that the Absorica brand could also be crazy or without food. Food helps increase the absorption of this drug into your bloodstream. Ask your doctor or pharmacist for more information. Take this drug with a full glass of water, and don't lie for a minimum of 10 minutes after taking it.
  • The dosage is predicated on your medical condition, weight, and response to treatment.
  • Your acne may worsen during the primary few days of taking this drug, and it's going to take up to 1-2 months before you notice the complete advantage of this medication. If severe acne returns, a second course of treatment could also be started after you've got stopped taking the drug for two months. The manufacturer doesn't recommend the long-term use of isotretinoin. Do not take more than the recommended dose.
  • Since this drug is often absorbed through the skin and lungs and should harm an unborn baby, women who are pregnant or who may become pregnant shouldn't handle this medication or breathe the dust from the capsules.

Side effects

  • Dry lips and mouth, minor swelling of the eyelids or lips, crusty skin, nosebleeds, indigestion, or thinning of hair may occur. If any of those effects persist or worsen, tell your doctor or pharmacist promptly.
  • To relieve xerostomia, suck on (sugarless) candy or ice chips, chew (sugarless) gum, drink water, or use a saliva substitute.
  • Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is bigger than the danger of side effects. Many people using this medication don't have serious side effects.
  • Tell your doctor directly if you've got any serious side effects, including mental/mood changes (such as depression, anxiety, thoughts of suicide), tingling feeling within the skin, back/joint/muscle pain, signs of infection (e.g., fever, persistent sore throat), painful swallowing, peeling skin on palms/soles.
  • Isotretinoin may rarely cause disease of the pancreas (pancreatitis) which will rarely be fatal. Stop taking this medication and tell your doctor right away if you develop: severe stomach pain, severe or persistent nausea/vomiting.
  • Stop taking this medication and tell your doctor right away if you develop these unlikely but very serious side effects: severe headache, vision changes, ringing in the ears, hearing loss, chest pain, yellowing eyes/skin, dark urine, severe diarrhea, rectal bleeding.
  • A very serious allergy to the present drug is rare. However, seek immediate medical attention if you notice any symptoms of a significant allergy, including rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
  • This is not an entire list of possible side effects. If you notice other effects ex-directory above, contact your doctor or pharmacist.


  • Before taking isotretinoin, tell your doctor or pharmacist if you're allergic to it, or to vitamin A-related drugs (other retinoids like tretinoin); or if you've got the other allergies. This product may contain inactive ingredients (such as soybean, parabens), which may cause allergies or other problems. Some people that are allergic to peanuts can also be allergic to soy. Talk to your pharmacist for more details.
  • Before using this medication, tell your doctor or pharmacist your medical record, especially of: diabetes, family or personal history of high blood fats (triglycerides), mental/mood problems (such as depression), liver disease, obesity, eating disorders (e.g., anorexia nervosa), alcoholic abuse, pancreatitis, bone loss conditions (e.g., osteoporosis/osteomalacia, decreased bone density).
  • Do not donate blood while you're taking isotretinoin and for a minimum of 1 month after you stop taking it.
  • This medication may cause you to more sensitive to the sun. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors. Tell your doctor directly if you get sunburned or have skin blisters/redness.
  • Isotretinoin can affect your night vision. Do not drive, use machinery, or do any activity that needs clear vision after dark until you're sure you'll perform such activities safely.
  • If you wear contact lenses, you'll not tolerate them also as was common while using this medication. Contact your doctor for more information.
  • Do not have cosmetic procedures to smooth your skin (e.g., waxing, laser, dermabrasion) during and for six months after isotretinoin therapy. Skin scarring may occur.
  • Avoid the utilization of alcohol while taking this medication because it's going to increase the danger of certain side effects (e.g., pancreatitis).
  • Limited information suggests isotretinoin may cause some bone loss effects. Therefore, playing contact or repetitive impact sports (e.g., football, basketball, soccer, tennis) may end in bone problems, including an increased risk of broken bones. Limited information also suggests isotretinoin may stop normal growth in some children (epiphyseal plate closure). Consult your doctor for more details.
  • Caution is usually recommended when using this drug within the elderly because they'll be more sensitive to its effects, especially the results on bones.
  • Caution is usually recommended when using this drug in children because they'll be more sensitive to its effects, especially back/joint/muscle pain.
  • This drug must not be used during pregnancy or by people who may become pregnant during treatment. If you become pregnant or think you will be pregnant, inform your doctor directly. See also Warning section.
  • Since this drug is often absorbed through the skin and lungs and will harm an unborn baby, women who are pregnant or who may become pregnant shouldn't handle this medication or breathe the dust from the capsules.
  • You must have two negative pregnancy tests before starting this medication. You must have a monthly bioassay during treatment with isotretinoin. If the test is positive, you want to stop taking this medication and consult your doctor directly.
  • It is unknown if this medication passes into breast milk. However, similar drugs pass into breast milk. Breast-feeding while using this drug is not recommended. Ask your doctor once you'll breast-feed after stopping treatment. Consult your doctor before breast-feeding.


  • Store at temperature faraway from light and moisture. Do not store in the bathroom. Keep all medications out of reach of kids and pets.
  • Do not flush medications down the remainder room or pour them into a drain unless instructed to undertake to so. Properly discard this product when it's expired or not needed. Consult your pharmacist or local waste disposal company.

Drug interactions

  • Drug interactions may change how your medications work or increase your risk for serious side effects. This document doesn't contain all possible drug interactions. Keep a listing of all the products you use (including prescription/nonprescription drugs and herbal products) and share it alongside your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.
  • Some products which can interact with this drug are tetracyclines (such as minocycline, tetracycline), vitamin A-type drugs (such as acitretin, bexarotene), vitamin A, drugs that cause bone loss (for example, anti-seizure drugs like phenytoin, corticosteroids like prednisone).
  • Tell your doctor once you begin any new drug and discuss if you need to use additional reliable contraception. Also, tell your doctor if you've any new spotting or breakthrough bleeding because these could even be signs that your contraception isn't working well

Missed Doses:

  • If you miss a dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.


Do not allow anyone else to need this medication. It can cause birth defects and other serious health problems.
Laboratory and/or medical tests should be performed (e.g., pregnancy, blood cholesterol/triglyceride levels, liver function, white blood count, eye exams) to observe for side effects.