Restless Leg Syndrome

3 Items

Set Descending Direction
  1. Generic: Pregabalin
    Equivalent Brand: Lyrica
    30 Capsule/s
  2. Generic: Pramipexole
    Equivalent Brand: Miraprex
    30 Tablet/s
  3. Generic: Ropinirole
    Equivalent Brand: Requip
    30 Tablet/s
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Restless Legs Syndrome (RLS), also known as Willis-Ekbom Disease, is a neurological disorder characterized by an uncontrollable urge to move the legs, often accompanied by uncomfortable sensations. These sensations typically occur during periods of inactivity or rest, such as when sitting or lying down, and can significantly disrupt sleep. Here's an overview of Restless Legs Syndrome, including its symptoms, causes, diagnosis, and potential treatment approaches:


1. Irresistible Urge to Move Legs:

  • Individuals with RLS experience a compelling urge to move their legs, often described as a "creepy" or "crawling" sensation.

2. Worsening at Rest:

  • Symptoms tend to worsen during periods of inactivity, such as when sitting or lying down.

3. Relief with Movement:

  • Movement, such as walking or stretching, provides temporary relief from the uncomfortable sensations.

4. Nighttime Symptoms:

  • RLS symptoms often peak during the evening or nighttime, leading to sleep disturbances.

Causes and Risk Factors:

1. Genetic Factors:

  • There is a genetic component, and RLS tends to run in families.

2. Dopamine Imbalance:

  • Changes in dopamine levels in the brain are believed to play a role, as dopamine is a neurotransmitter involved in muscle movement.

3. Iron Deficiency:

  • Low iron levels, especially in the brain, have been associated with RLS.

4. Pregnancy:

  • Some women may experience RLS during pregnancy, particularly in the third trimester.

5. Certain Medical Conditions:

  • Chronic conditions such as kidney failure, diabetes, and peripheral neuropathy may increase the risk of RLS.

6. Medications:

  • Certain medications, including antipsychotics and anti-nausea drugs, may exacerbate or trigger RLS symptoms.


1. Clinical Evaluation:

  • A healthcare provider will assess symptoms, medical history, and potential contributing factors.

2. Blood Tests:

  • Checking iron levels and ruling out other underlying conditions.

3. Sleep Studies:

  • Polysomnography may be conducted to assess sleep patterns and the impact of RLS on sleep.

Treatment Approaches:

1. Lifestyle Modifications:

  • Regular exercise, maintaining a consistent sleep schedule, and avoiding stimulants can help manage symptoms.

2. Iron Supplementation:

  • If iron deficiency is identified, supplementation may be recommended.

3. Medications:

  • Dopamine agonists, such as pramipexole and ropinirole, are commonly prescribed to regulate dopamine levels.

4. Anticonvulsants:

  • Certain anticonvulsant medications may be effective in reducing RLS symptoms.

5. Opioids:

  • In severe cases, opioids may be prescribed, but their use is generally limited due to potential side effects and risks.

6. Sleep Medications:

  • Medications that promote sleep, such as certain benzodiazepines, may be recommended.


1. Good Sleep Hygiene:

  • Establishing a regular sleep routine and creating a comfortable sleep environment.

2. Addressing Underlying Conditions:

  • Managing and treating conditions that may contribute to or exacerbate RLS.


Restless Legs Syndrome can significantly impact daily life and sleep quality. While there is no cure, various treatment approaches can effectively manage symptoms and improve overall well-being. Individuals experiencing persistent or bothersome symptoms should consult with a healthcare professional for an accurate diagnosis and appropriate management plan.