Iron overload

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  1. Generic: Deferasirox
    Equivalent Brand: Exjade
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Iron overload, also known as hemochromatosis, is a medical condition characterized by an excessive accumulation of iron in the body. This condition can lead to various health complications due to the buildup of iron in organs and tissues. Here's an overview of iron overload, its causes, symptoms, diagnosis, and potential treatment approaches:


1. Hereditary Hemochromatosis:

  • The most common cause is hereditary hemochromatosis, an inherited disorder that causes the body to absorb and store too much iron.

2. Secondary Hemochromatosis:

  • Resulting from other medical conditions such as thalassemia, chronic liver disease, or repeated blood transfusions.

3. Excessive Iron Intake:

  • Rarely, iron overload can occur due to excessive iron supplementation or frequent blood transfusions.


1. Fatigue:

  • Excessive iron can lead to fatigue and weakness.

2. Joint Pain:

  • Iron accumulation in joints may cause pain and stiffness.

3. Abdominal Pain:

  • Iron overload can affect the liver, leading to abdominal pain.

4. Skin Color Changes:

  • The skin may take on a bronze or gray color.

5. Heart Problems:

  • Iron accumulation in the heart can result in heart problems, including heart failure.

6. Diabetes:

  • Iron overload is associated with an increased risk of developing diabetes.


1. Blood Tests:

  • Serum ferritin and transferrin saturation tests measure iron levels in the blood.

2. Genetic Testing:

  • Genetic testing can identify mutations associated with hereditary hemochromatosis.

3. Liver Biopsy:

  • A liver biopsy may be performed to assess iron levels in the liver.

4. MRI:

  • Magnetic resonance imaging (MRI) can help evaluate iron levels in the liver and other organs.

Treatment Approaches:

1. Phlebotomy (Blood Removal):

  • The most common treatment involves regular removal of blood to reduce iron levels. This is similar to blood donation but is done more frequently.

2. Iron Chelation Therapy:

  • Medications known as iron chelators may be prescribed to help the body excrete excess iron.

3. Dietary Changes:

  • Limiting dietary iron intake, including avoiding iron supplements and iron-rich foods.

Management of Underlying Conditions:

  • Treating and managing underlying conditions contributing to secondary hemochromatosis.


1. Genetic Counseling:

  • Individuals with a family history of hereditary hemochromatosis may benefit from genetic counseling.

2. Monitoring Iron Levels:

  • Regular monitoring of iron levels in individuals at risk for iron overload.

3. Limiting Iron Intake:

  • Avoiding unnecessary iron supplementation and excessive consumption of iron-rich foods.


Iron overload is a serious condition that requires medical attention and management. Early diagnosis and appropriate treatment can prevent complications associated with excessive iron accumulation in the body. Individuals with symptoms or risk factors for iron overload should consult with healthcare professionals for evaluation and guidance.