Humog HP Injection (Menotrophin) | Used for Ovulation Induction and Fertility Enhancement
Humog HP Injection (Menotrophin) is a gonadotropin used to treat female infertility and male hypogonadism. Stimulates egg development and ovulation in women and improves sperm count in men. Menotrophin is an active ingredient that belongs to the class of Gonadotropins.
Product Overview
Humog HP Injection is a highly purified human menopausal gonadotropin (hMG) containing Menotrophin. This potent hormonal therapy is primarily utilized in reproductive medicine to address various forms of infertility. By providing a controlled balance of follicle-stimulating and luteinizing activities, it mimics the body’s natural signals to the reproductive organs, facilitating the development and maturation of follicles in women and supporting sperm production in men.
Product Composition
- Active Ingredient: Menotrophin (Human Menopausal Gonadotropin)
- Hormonal Components:
- Follicle-Stimulating Hormone (FSH) activity
- Luteinizing Hormone (LH) activity
- Formulation: Lyophilized (freeze-dried) powder for injection with a separate solvent ampoule.
- Common Strengths: 75 IU, 150 IU
- Purity: Highly Purified (HP) to ensure consistent bioactivity and local tolerance.
Product Specifications
| Feature | Specification |
| Drug Category | Gonadotropin / Ovulation Stimulant |
| Therapeutic Class | Infertility Therapy |
| Route of Administration | Intramuscular (IM) or Subcutaneous (SC) |
| Source | Purified from the urine of postmenopausal women |
| Storage | Store below 25°C; protect from light; use immediately after reconstitution |
Mechanism of Action
- Ovarian Follicle Stimulation: In women, the FSH component of Menotrophin stimulates the growth and recruitment of multiple ovarian follicles. The LH component works concurrently to support the maturation of these follicles and the production of estrogen.
- Steroidogenesis: It promotes the synthesis of steroid hormones within the gonads, which is essential for the preparation of the uterine lining (endometrium) in women.
- Induction of Ovulation: Once follicles have reached the appropriate size, a separate hormone (such as hCG) is usually administered to trigger the final release of the egg.
- Spermatogenesis Support: In men with hypogonadotropic hypogonadism, Menotrophin stimulates the Sertoli cells in the testes to initiate and maintain the production of healthy sperm.
Key Benefits
- Balanced Hormonal Ratio: Provides a 1:1 ratio of FSH and LH activity, which is often essential for patients who require LH support for optimal follicular development.
- Highly Purified (HP) Quality: The advanced purification process reduces non-specific proteins, leading to better injection site comfort and predictable clinical responses.
- Versatile Infertility Management: Effective for a wide range of conditions, from simple ovulation induction to complex Assisted Reproductive Technology (ART) cycles like IVF.
- Customizable Dosing: Available in multiple strengths to allow clinicians to tailor the dosage precisely based on the patient's ultrasound and hormonal monitoring.
- Dual-Gender Utility: Provides a critical therapeutic option for both female and male endocrine-related fertility issues.
Precautions
Medical supervision
- Use Humog HP Injection (Menotrophin) only under specialist supervision
- Must be administered by a trained healthcare professional
- Do not self-inject or change dosage on your own
- Close monitoring throughout treatment is essential
Health conditions
| Condition | Precaution |
|---|---|
| Ovarian cysts | May require evaluation before starting treatment |
| Unexplained vaginal bleeding | Must be diagnosed first |
| Thyroid/adrenal disorders | May affect treatment response |
| Reproductive organ tumors | Use only if advised by specialist |
| Primary ovarian failure | May not respond effectively |
Ovarian hyperstimulation syndrome (OHSS)
- Risk of overstimulation of ovaries
- Symptoms: abdominal pain, bloating, nausea, rapid weight gain
- Severe cases may cause breathing difficulty or fluid buildup
- Immediate medical attention required if symptoms appear
Pregnancy-related precautions
- Used only in controlled fertility programs (e.g., IVF)
- Frequent ultrasound and hormone monitoring required
- Timing of injections is critical for success
Injection safety
- Should be given using sterile technique only
- Do not reuse needles or vials
- Report pain, swelling, or redness at injection site
Lifestyle precautions
- Avoid smoking and alcohol during treatment
- Maintain healthy diet and hydration
- Avoid strenuous physical activity if ovaries are enlarged
Monitoring advice
- Regular ultrasound scans to monitor follicle growth
- Hormone level testing may be required
- Report severe abdominal pain, vomiting, or breathing difficulty immediately
Usage
Humog HP Injection is a specialized hormonal treatment that must be administered under the strict supervision of a fertility specialist. Because it directly influences the reproductive system, precise timing and regular clinical monitoring via ultrasound and blood tests are essential to ensure a safe and effective response.
Dosage and Administration
Adhering to the prescribed injection protocol is vital for the successful stimulation of the gonads.
Administration Route: This medication is administered via Intramuscular (IM) or Subcutaneous (SC) injection. The specific route is determined by the healthcare provider based on the patient's treatment plan.
Reconstitution: The lyophilized powder must be dissolved using the provided solvent just before use. Gently swirl the vial to mix; do not shake the solution, as this can degrade the hormones.
Timing: Injections should be administered at approximately the same time every day to maintain stable hormonal levels. For women, treatment typically begins within the first few days of the menstrual cycle.
Dose Customization: The starting dose is individualized based on age, body weight, and previous response to fertility drugs. A physician may adjust the dose every few days based on the growth of the follicles observed during monitoring.
Clinical Monitoring: During a cycle, regular transvaginal ultrasounds and blood tests to measure estradiol levels are required to track progress and prevent overstimulation.
Final Maturation: Once the follicles reach the target size, a final injection of Human Chorionic Gonadotropin (hCG) is usually given to trigger the release of the egg.
Storage of Reconstituted Solution: Any unused portion of the mixed solution should be discarded immediately; do not save it for a later dose.
Missed Dose: If a dose is missed, contact your fertility clinic immediately for instructions. Do not take a double dose to catch up.
Uses
Humog HP Injection is indicated for the treatment of various hormonal imbalances that affect the ability to conceive.
Primary Therapeutic Uses
Ovulation Induction: Used in women who do not ovulate or have irregular cycles (such as those with Polycystic Ovary Syndrome - PCOS) to stimulate the development of a dominant follicle.
Assisted Reproductive Technology (ART): A cornerstone of In Vitro Fertilization (IVF) and ICSI cycles, where it is used for "controlled ovarian hyperstimulation" to produce multiple eggs for retrieval.
Management of Hypogonadotropic Hypogonadism: Indicated for women with low levels of natural gonadotropins (FSH and LH), providing the necessary signals for the ovaries to function.
Treatment of Male Infertility: Prescribed to men with hormonal deficiencies to stimulate spermatogenesis (sperm production), often in combination with hCG therapy.
Luteal Phase Support: Occasionally used to support the development of the corpus luteum, ensuring the uterine environment is prepared for the implantation of an embryo.
Diagnostic Utility: Sometimes used in specialized clinical tests to evaluate the functional capacity of the ovaries or testes.
Side effects
Common side effects
- Abdominal pain or discomfort
- Bloating
- Nausea
- Headache
- Injection site pain, redness, or swelling
- Mild weight gain
Ovarian effects
- Ovarian enlargement
- Multiple follicle development
- Pelvic discomfort or heaviness
Hormonal effects
- Breast tenderness
- Mood changes
- Hot flushes
Digestive system effects
- Vomiting (less common)
- Mild stomach upset
Serious side effects (rare)
| Serious effect | Possible signs |
|---|---|
| Ovarian hyperstimulation syndrome (OHSS) | Severe abdominal pain, rapid weight gain, bloating, breathlessness |
| Severe allergic reaction | Rash, swelling, difficulty breathing |
| Fluid accumulation | Swelling of abdomen or legs |
| Multiple pregnancy risk | Twins or more pregnancies |
| Severe pelvic pain | Persistent or worsening pain |
Important warning
- Stop use and seek immediate medical attention if severe abdominal pain, breathing difficulty, or rapid weight gain occurs
- Regular ultrasound and hormone monitoring are essential during treatment
- Report any unusual or worsening symptoms promptly to your fertility specialist
FAQs
Q: What is Humog HP Injection used for?
A: Humog HP Injection is used to treat infertility in both men and women. In women, it stimulates egg development and ovulation. In men, it improves sperm count and treats male hypogonadism and delayed puberty.
Q: What is the active ingredient in Humog HP Injection?
A: The active ingredient is Menotrophin, a highly purified human menopausal gonadotropin (HMG) containing equal amounts of follicle stimulating hormone (FSH) and luteinising hormone (LH). It is available in 75 IU and 150 IU strengths.
Q: How does Humog HP Injection work?
A: In women, Menotrophin stimulates the growth and maturation of egg follicles in the ovaries, increases oestrogen levels, and promotes proliferation of the endometrium, leading to the release of a mature egg. In men, it stimulates sperm production by acting on the seminiferous tubules of the testes and increases testosterone levels.
Q: How is Humog HP Injection administered?
A: Humog HP Injection is given as an injection under the skin or into a muscle by a doctor or nurse. Do not self-administer this medicine. The dose, frequency, and duration of treatment are determined by your doctor based on your gender, condition, and response to treatment.
Q: How long does treatment with Humog HP Injection last?
A: In women, the duration of treatment depends on the ovarian response, which is monitored regularly by the doctor through oestrogen level tests and ultrasound. In men, treatment duration is decided by the doctor based on sperm count and hormonal response.
Q: What are the common side effects of Humog HP Injection?
A: Common side effects include stomach pain or swelling, nausea, headache, fatigue, dizziness, depression, restlessness, and injection site reactions such as pain, redness, and swelling. Most are mild and resolve on their own. Consult your doctor if they persist or worsen.
Q: What is ovarian hyperstimulation syndrome (OHSS)?
A: OHSS is a serious but rare complication of fertility treatment where the ovaries respond too strongly to the hormone injections. Symptoms include severe stomach pain, bloating, nausea, vomiting, and shortness of breath.
Q: Who should not take Humog HP Injection?
A: Avoid if you are allergic to Menotrophin or any of its ingredients. Also avoid if you have tumours of the breast, uterus, testes, prostate, pituitary gland or hypothalamus, polycystic ovarian disease with enlarged ovaries, heavy vaginal bleeding, high blood prolactin levels, thyroid or adrenal gland problems, or fibroids in the uterus.
Q: Can Humog HP Injection be used during pregnancy?
A: No, Humog HP Injection should not be used during pregnancy. Inform your doctor immediately if you become pregnant during treatment.
Q: Is Humog HP Injection safe during breastfeeding?
A: Consult your doctor before taking Humog HP Injection while breastfeeding as its safety during breastfeeding has not been fully established.
Q: Can Humog HP Injection be used in children?
A: Humog HP Injection is not intended for use in children and adolescents below 18 years of age. Consult your doctor before using it in this age group.
Q: Can Humog HP Injection be used in women with polycystic ovarian disease (PCOD)?
A: Yes, Humog HP Injection can be used in women with PCOD who are not responding adequately to other medicines such as clomiphene citrate. However, it is not recommended in patients with polycystic ovarian disease with enlarged ovaries. Close monitoring is required during treatment.
Interactions
Other fertility medicines
- May increase ovarian response when used with other ovulation-inducing drugs
- Requires careful dose adjustment and monitoring
- Higher risk of ovarian hyperstimulation (OHSS)
GnRH agonists/antagonists
- Commonly used together in IVF protocols
- May alter follicle stimulation response
- Requires specialist supervision for timing and dosing
Hormonal medicines
- Estrogen or progesterone therapy may affect treatment outcomes
- Hormone levels should be closely monitored
Other gonadotropins
- Combined use may significantly increase ovarian stimulation
- Higher risk of multiple follicle development
- Close ultrasound monitoring is essential
Antibiotics or routine medicines
- No major direct interactions known
- Still inform doctor about all medications being used
General advice
- Always inform your fertility specialist about all ongoing medicines
- Do not start or stop any medication without medical guidance
- Strict monitoring is required during treatment cycles
| Manufacturer | : | A. Menarini India Pvt Ltdine HCL) |
| Trade Name | : | Menopur, Repronex |
| Generic Search | : | Menotrophin |
| Strength | : | 75IU, 150IU |
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