Aristogyl Tablet (Metronidazole Tablets) Used to Treat Bacterial and Parasitic Infection In Various Parts of Body
Aristogyl Tablet contains Metronidazole, a nitroimidazole antimicrobial agent used to treat a wide range of anaerobic bacterial infections and protozoal infections, including amoebiasis, giardiasis, trichomoniasis, bacterial vaginosis, and intra-abdominal, skin, and soft tissue infections.
Product Overview
Aristogyl Tablet is a highly effective nitroimidazole antimicrobial agent containing Metronidazole. It is a cornerstone treatment for a wide range of infections caused by anaerobic bacteria and specific parasites. This versatile antibiotic is particularly renowned for its ability to penetrate deep tissues and abscesses, making it an essential medication for gastrointestinal, gynecological, and dental infections. By targeting the metabolic processes of pathogens, it ensures rapid infection clearance and symptomatic relief.
Product Composition
- Metronidazole: The active antimicrobial ingredient (available in 400mg) which provides powerful bactericidal and antiprotozoal activity.
- Starch: Used as a pharmaceutical binder to maintain the structural integrity and hardness of the tablet.
- Magnesium Stearate: A high-quality lubricant that ensures consistent tablet formulation and prevents sticking during the manufacturing process.
- Purified Talc: Acts as a glidant to improve the flow of the powder mix, ensuring accurate dosage in every unit.
- Colloidal Silicon Dioxide: Included to enhance the stability of the active pharmaceutical ingredient and prevent moisture absorption.
Product Specification
| Feature | Details |
| Therapeutic Class | Nitroimidazole Antibiotic / Antiprotozoal |
| Standard Strengths | 400mg Tablets |
| Absorption | Rapid and nearly complete (over 80% bioavailability) |
| Distribution | Wide distribution to most body tissues and fluids, including the CSF |
| Metabolism | Primarily Hepatic (Liver) |
| Excretion | Mostly Renal (Urinary) with some biliary elimination |
Mechanism of Action
- Aristogyl works by entering the microbial cell via passive diffusion and undergoing a reduction reaction within the pathogen.
- This process creates reactive intermediate metabolites that directly interact with the organism's DNA.
- These metabolites cause a loss of helical DNA structure and strand breakage, which inhibits the synthesis of nucleic acids.
- By disrupting the genetic blueprint of the pathogen, the medication leads to bacterial cell death or the neutralization of protozoa.
- The drug is uniquely selective for anaerobic environments, as the necessary chemical reduction only occurs under low-oxygen conditions.
Key Benefits
- Highly effective against amoebiasis and giardiasis, providing a reliable solution for severe intestinal parasitic infections.
- Excellent efficacy in treating anaerobic infections of the abdomen, such as peritonitis or liver abscesses.
- A gold-standard treatment for bacterial vaginosis and other trichomonal urogenital infections.
- Provides rapid relief for dental infections, including acute gingivitis and dental abscesses, due to its strong anaerobic coverage.
- Utilized as part of a multi-drug regimen to eradicate Helicobacter pylori, reducing the risk of peptic ulcer recurrence.
- Offers a cost-effective oral antibiotic option with a long history of clinical success and safety.
Precautions
| General Precaution | Details |
|---|---|
| Use only on prescription | Take Aristogyl Tablet only as directed by a doctor |
| Complete full course | Stopping early may lead to recurrence of infection |
| Avoid alcohol | Alcohol may cause severe reactions during treatment |
| Take with food | Helps reduce stomach discomfort |
| Follow dosage properly | Do not skip or double doses |
Medical Supervision
- Inform your doctor about any allergies or existing illnesses
- Share your complete medical history before starting treatment
- Use only for the prescribed duration
Health Condition Precautions
- Use carefully in liver disease patients
- Caution in neurological disorders or seizure history
- Dose adjustment may be needed in severe illness
During Treatment Care
- Avoid alcohol during treatment and for a few days after completion
- Stay hydrated during therapy
- Report numbness, tingling or unusual symptoms immediately
Pregnancy and Breastfeeding
- Use only if prescribed by a doctor
- Consult your doctor before use during breastfeeding
Safety Advice
- Do not self-medicate or reuse old prescriptions
- Avoid combining with other antibiotics without advice
- Store in a cool and dry place away from moisture
Usage
The administration of Metronidazole requires consistency to maintain effective bactericidal levels in the tissues and bloodstream.
Administration
Meal Timing: For best results and to minimize gastrointestinal upset, take the tablets during or after meals with a full glass of water.
Alcohol Contraindication: It is strictly mandatory to avoid alcohol during treatment and for at least 48 hours after the last dose to prevent a disulfiram-like reaction (nausea, vomiting, and flushing).
Swallow Whole: Do not crush or chew the tablets; the film-coated formulation is designed to mask the naturally bitter metallic taste of the medication.
Hydration: Maintain adequate fluid intake throughout the day to support the metabolic clearance of the drug.
Compliance: Complete the entire antibiotic course even if symptoms subside within the first few days to prevent the development of antimicrobial resistance.
Clinical Administration Summary
| Factor | Guideline |
| Dosing Interval | Every 8 hours (Three times daily) |
| Alcohol Interaction | Strict Avoidance Required |
| Side Effect Note | May cause a harmless darkening of urine |
| Metallic Taste | Common; taking with food helps mitigate this effect |
Uses
Treatment of intestinal amoebiasis (amoebic dysentery) and extra-intestinal complications like amoebic liver abscess.
Management of Giardiasis, an intestinal infection characterized by abdominal cramps and watery diarrhea.
Resolution of Trichomoniasis, a common sexually transmitted infection affecting the urogenital tract.
Therapy for bacterial vaginosis caused by Gardnerella vaginalis and other anaerobic organisms.
Control of anaerobic infections involving the respiratory tract, central nervous system, and intra-abdominal cavity.
Treatment of acute ulcerative gingivitis and other serious infections of the gums and dental structures.
Eradication of Helicobacter pylori in patients with peptic ulcers, typically used in combination with a proton pump inhibitor and other antibiotics.
Prophylaxis against post-operative infections following elective colorectal or gynecological surgery.
Side Effects
Common Side Effects
- Nausea
- Vomiting
- Metallic taste in mouth
- Abdominal discomfort
- Headache
Less Common Side Effects
- Diarrhea
- Loss of appetite
- Dizziness
- Dry mouth
- Dark colored urine
Serious Side Effects
| Serious Side Effect | Details |
|---|---|
| Severe allergic reaction | Rash, swelling or breathing difficulty |
| Nerve problems | Numbness, tingling or seizures |
| Severe stomach pain | May indicate serious gastrointestinal effects |
| Liver problems | Yellowing of skin or dark urine |
| Severe skin reactions | Rare but may require urgent medical care |
When to Seek Medical Help
- If severe rash or breathing difficulty occurs
- If numbness, tingling or seizures develop
- If persistent vomiting or severe stomach pain appears
- If yellowing of skin or eyes is noticed
FAQs
Q: What are Aristogyl Tablets used for?
A: Aristogyl Tablets are used to treat anaerobic bacterial infections and protozoal infections including amoebiasis, giardiasis, trichomoniasis, bacterial vaginosis, intra-abdominal infections, skin and soft tissue infections, and dental infections.
Q: How do Aristogyl Tablets work?
A: Metronidazole works by entering microbial cells and disrupting their DNA synthesis, leading to cell death in susceptible anaerobic bacteria and protozoa.
Q: What is the recommended dose of Aristogyl Tablets?
A: The usual adult dose is 400–800 mg two to three times daily, depending on the type and severity of infection, as prescribed by the doctor.
Q: Should Aristogyl Tablets be taken with food?
A: Aristogyl Tablets should be taken with or after food to reduce the risk of gastrointestinal side effects such as nausea and stomach upset.
Q: How long should I take Aristogyl Tablets?
A: Treatment duration typically ranges from 5 to 10 days depending on the type and severity of infection. Always complete the full course as prescribed by your doctor.
Q: What are the common side effects?
A: Common side effects include nausea, vomiting, metallic taste in the mouth, diarrhea, abdominal cramps, headache, and dizziness. Inform your doctor if any side effects persist or worsen.
Q: Can I drink alcohol while taking Aristogyl Tablets?
A: No. Alcohol must be strictly avoided during treatment and for at least 48 hours after completing the course, as it can cause a severe disulfiram-like reaction including flushing, nausea, vomiting, and rapid heartbeat.
Q: Is it safe to take Aristogyl Tablets during pregnancy?
A: Metronidazole should be used with caution during pregnancy, particularly in the first trimester. Consult your doctor before use as it is generally avoided unless clearly necessary.
Interactions
| Interaction Type | Details |
|---|---|
| Alcohol | May cause nausea, vomiting and flushing |
| Blood thinners | May increase bleeding risk |
| Lithium | Can increase lithium toxicity |
| Anti-seizure medicines | May alter effectiveness of Metronidazole |
| Other antibiotics | Combined use may affect treatment response |
Medicine Interactions
- Inform your doctor about all medicines you are taking
- Use caution with anticoagulants like warfarin
- Avoid combining with disulfiram unless advised by a doctor
Food and Beverage Interactions
- Strictly avoid alcohol during treatment and for a few days after completion
- Take with food to reduce stomach upset
- Maintain proper hydration during therapy
Disease Related Interactions
- Use carefully in liver disease patients
- Caution in neurological disorders or seizure history
- Dose adjustment may be needed in severe conditions
Important Safety Advice
- Report unusual symptoms like numbness or severe dizziness immediately
- Do not self-combine with other antibiotics without medical advice
- Follow prescribed dose and duration strictly
| Manufacturer | : | A. Menarini India Pvt Ltdine HCL) |
| Trade Name | : | Flagyl |
| Generic Search | : | Metronidazole |
| Strength | : | 400mg |
Latest Products
