Zentel Medicine Tablet (Albendazole 400mg) | Used to Treat Worm (Helminths) Infections
Zentel Tablet contains Albendazole 400 mg, an effective broad-spectrum anti-parasitic medicine used to treat various intestinal worm infections such as roundworms, pinworms, and tapeworms. Zentel Tablet works by preventing the growth and reproduction of parasites, helping to eliminate infections and relieve related symptoms like abdominal pain, diarrhea, and nausea. It is a reliable and fast-acting solution for maintaining digestive health.
Product Overview
Zentel 400mg Tablet is a highly effective broad-spectrum anthelmintic medication designed to eliminate various parasitic worm infections. It is widely utilized for both intestinal and systemic parasitic conditions, offering a reliable solution for deworming in adults and pediatric patients.
Product Composition
- Active Ingredient: Albendazole
- Strength: 400mg per tablet
- Chemical Class: Benzimidazole derivative
- Inactive Ingredients: May include lactose, microcrystalline cellulose, maize starch, sodium lauryl sulfate, and flavoring agents depending on the specific chewable formulation.
Product Specification
| Feature | Details |
| Brand Name | Zentel |
| Dosage Strength | 400mg |
| Dosage Form | Oral Tablet (Chewable) |
| Packaging Type | Blister Strip |
| Storage Conditions | Store below 30°C in a dry place |
Mechanism of Action
The active ingredient works by interfering with the structural integrity of the parasite. It binds to the beta-tubulin protein of the worm, preventing the polymerization of microtubules. This disruption leads to:
- Energy Depletion: The parasite becomes unable to absorb glucose, leading to a total loss of energy reserves.
- Immobilization: The lack of energy causes the parasite to become paralyzed.
- Elimination: Once immobilized, the parasite dies and is naturally cleared from the body through the digestive tract.
Key Benefits
- Comprehensive Treatment: Effectively targets roundworms, whipworms, hookworms, and certain tapeworms.
- Larvicidal and Ovicidal: Not only kills adult worms but also destroys larvae and eggs to break the infection cycle.
- Enhanced Absorption: For deep-tissue infections, absorption is significantly improved when taken with a fatty meal.
- User-Friendly Design: The tablets can be crushed, chewed, or swallowed whole, providing flexibility for different patient needs.
- Proven Safety Profile: Established as a standard treatment for mass deworming programs worldwide.
Precautions
General Safety Guidelines
- Use Zentel Tablet exactly as prescribed for treating intestinal worm infections
- Take the tablet with water, preferably after a meal to reduce stomach upset
- Do not alter the dose or duration of Albendazole 400 mg therapy without consulting your doctor
Allergy and Sensitivity
- Avoid use if allergic to Albendazole or any other ingredients in Zentel Tablet
- Discontinue immediately and seek medical attention if you experience:
- Rash
- Itching
- Swelling
- Difficulty breathing
Use in Special Populations
- Not recommended for children under 2 years unless specifically advised by a healthcare provider
- Use with caution in elderly patients or those with liver or kidney conditions
- Consult your doctor before using Zentel Tablet during pregnancy or breastfeeding
Health and Medical Considerations
| Condition | Precautions |
|---|---|
| Liver disease | Use with caution; monitor liver function during treatment |
| Kidney disease | Use under medical supervision; dose adjustment may be required |
| Blood disorders | Monitor blood count if pre-existing anemia or other blood conditions exist |
| Pregnancy | Consult doctor; not recommended in first trimester unless necessary |
| Breastfeeding | Consult doctor before use; may pass into breast milk |
Drug and Lifestyle Considerations
- Inform your doctor about all medications, especially anti-seizure drugs or other anti-parasitics
- Avoid alcohol while taking Zentel Tablet to reduce liver stress
- Maintain a healthy diet and hydration to support effective treatment
Administration and Storage Guidelines
- Take Zentel Tablet with water after meals
- Store in a cool, dry place away from direct sunlight
- Keep out of reach of children
- Do not use expired Albendazole 400 mg tablets
Usage
Zentel 400mg Tablet is designed for the effective removal of various parasitic worms from the body. It is important to follow the correct administration steps to ensure the medication properly targets the infection and prevents a recurrence.
Dosage and Administration
The dosage of this medication varies depending on the type of infection and the patient's body weight. It is essential to complete the entire course as directed by a healthcare professional.
Method of Intake: Tablets can be swallowed whole, chewed, or crushed and mixed with food for patients who have difficulty swallowing.
Consistency in Timing: For optimal results, take the dose at a fixed time each day.
Enhancing Absorption: In cases of systemic or tissue-based infections, taking the tablet with a fatty meal significantly improves the absorption of the active ingredient.
Hydration: Ensure adequate fluid intake throughout the treatment period.
Missed Dose Protocol: If a dose is forgotten, take it as soon as you remember. If the next scheduled dose is near, skip the missed one. Do not take two tablets at once.
Administration Guidelines
| Type of Infection | Typical Patient Group | Standard Dosage Schedule |
| Common Intestinal Worms | Adults & Children over 2 years | Single 400mg dose |
| Tapeworm & Strongyloidiasis | Adults & Children over 2 years | 400mg daily for 3 consecutive days |
| Systemic Tissue Infections | Weight over 60 kg | 400mg twice daily for 8 to 30 days |
| Pediatric Systemic Infections | Weight under 60 kg | 15mg/kg daily (divided into 2 doses) |
Uses
Intestinal Deworming: Eliminates common parasites like roundworms, hookworms, and pinworms.
Neurocysticercosis Treatment: Manages infections in the nervous system caused by pork tapeworms.
Hydatid Disease Management: Treats parasitic infections of the liver, lung, and peritoneum caused by dog tapeworms.
Giardiasis Control: Effective in treating certain protozoal infections in children.
Mixed Infestations: Clears multiple types of worm infections occurring simultaneously.
Larvicidal Action: Targets and destroys developing larvae in various body tissues.
Side Effects
Common Side Effects
- Nausea or vomiting
- Abdominal pain or discomfort
- Diarrhea
- Headache
- Dizziness
- Mild fever
Less Common Side Effects
- Loss of appetite
- Fatigue or weakness
- Rash or skin irritation
- Itching
Rare but Serious Side Effects
- Severe allergic reactions: swelling, rash, difficulty breathing
- Liver problems: yellowing of skin or eyes (jaundice)
- Blood disorders: unusual bleeding, bruising, or persistent fatigue
- Severe abdominal pain or persistent vomiting
Health Monitoring Table
| System / Condition | Potential Side Effects |
|---|---|
| Gastrointestinal System | Nausea, vomiting, abdominal pain, diarrhea |
| Nervous System | Headache, dizziness, fatigue |
| Skin and Allergy | Rash, itching, allergic reactions |
| Liver Function | Jaundice, liver enzyme elevation |
| Blood / Hematologic | Anemia, unusual bruising, changes in white blood cells |
Recommendations
- Report any persistent or severe side effects to your doctor immediately
- Monitor liver function if taking Zentel Tablet for more than a few days
- Maintain hydration and a balanced diet to reduce gastrointestinal discomfort
- Do not stop Albendazole 400 mg without consulting your healthcare provider
FAQ’s
1. Is Zentel an antibiotic?
No, it is an anthelmintic drug, not an antibiotic.
2. Is Zentel over the counter in the USA?
No, Albendazole (Albenza) is only available with a doctor's prescription.
3. Does albendazole require a prescription?
Yes, albendazole is available only with a doctor's prescription.
4. How soon does Zentel work?
The effectiveness depends on the condition and other factors. Follow your doctor's advice for best results.
5. How long does Zentel take to kill worms?
Zentel usually starts killing worms within a few hours to a few days after taking the dose.
For most intestinal worm infections, a single dose or short course is effective. In some infections, a repeat dose after 2 weeks may be required to fully eliminate the worms.
6. Can you take Zentel on an empty stomach?
-For intestinal worm infections, Zentel is often taken with or without food
-For tissue infections (such as hydatid disease or neurocysticercosis), Zentel should be taken with food, preferably a fatty meal, to improve absorption
7. Is Zentel approved in the US, UK, Canada, and Australia?
Yes. Albendazole (the active ingredient in Zentel) is approved or prescribed in:
United States (FDA-approved generic albendazole)
United Kingdom (MHRA-regulated)
Canada (Health Canada)
Australia (TGA-approved)
Other countries worldwide under national regulatory authorities
Availability may vary by brand name and prescription rules.
Interactions
Drug Interactions
- Inform your doctor if taking any of the following along with Zentel Tablet:
- Anti-seizure medications (e.g., phenytoin, carbamazepine)
- Cimetidine or other stomach acid reducers
- Dexamethasone or corticosteroids
- Other anti-parasitic medicines
- Combining Albendazole 400 mg with certain drugs may:
- Reduce effectiveness of Zentel Tablet
- Increase risk of liver toxicity
- Alter blood count levels
Food and Lifestyle Interactions
- Take Zentel Tablet after meals to improve absorption and reduce stomach upset
- Avoid alcohol during treatment to prevent liver stress
- Maintain proper hydration to support elimination of parasites
Health Condition Interactions
| Condition | Interaction Precautions |
|---|---|
| Liver disease | Monitor liver function closely; may require dose adjustment |
| Kidney disease | Use cautiously and under supervision |
| Blood disorders | Monitor blood counts during treatment |
| Pregnancy | Only use if prescribed by doctor; not recommended in first trimester |
| Breastfeeding | Consult doctor before use; may pass into breast milk |
Other Considerations
- Inform your doctor about all vitamins, supplements, or herbal products being taken
- Do not start or stop any medication while using Zentel Tablet without medical advice
| Manufacturer | : | GlaxoSmithKline Consumer Healthcare |
| Trade Name | : | Albenza |
| Generic Search | : | Albendazole |
| Strength | : | 400mg |
















