Stamlo Tablet (Amlodipine) Used to Treat High Blood Pressure and Angina (Heart Related Chest Pain)
Stamlo Tablet (Amlodipine) is used for the treatment of high blood pressure (hypertension) and angina (chest pain). It lowers blood pressure and reduces the heart's workload, which helps prevent heart attacks and strokes. Amlodipine works by relaxing and widening the blood vessels in the body, allowing for improved blood flow and reducing the workload on the heart. It and is also referred to as Norvasc.
Product Overview
Stamlo Tablet is a widely prescribed cardiovascular medication containing Amlodipine, a potent long-acting calcium channel blocker (CCB) designed to manage hypertension and chronic stable angina. By selectively inhibiting the influx of calcium ions into vascular smooth muscle and cardiac muscle, Stamlo facilitates the relaxation of blood vessels, which effectively lowers blood pressure and improves blood flow to the heart. This medication is a foundational treatment in preventing serious cardiovascular events such as strokes, heart attacks, and kidney failure. Its once-daily dosing profile ensures stable blood pressure control over a full 24-hour period, making it a reliable choice for long-term heart health management.
Product Composition
- Active Ingredient: Amlodipine Besylate (equivalent to 2.5mg, 5mg, or 10mg of Amlodipine)
- Binding Agents: Microcrystalline Cellulose
- Disintegrants: Sodium Starch Glycolate
- Lubricants: Magnesium Stearate
- Fillers: Calcium Hydrogen Phosphate (Anhydrous)
- Coating: Film-coated for ease of swallowing
Product Specification
| Feature | Details |
| Drug Class | Dihydropyridine Calcium Channel Blocker |
| Available Strengths | 2.5mg, 5mg, 10mg |
| Primary Indication | Hypertension and Coronary Artery Disease |
| Dosage Form | Oral Tablet |
| Pharmacological Action | Vasodilation |
| Half-Life | Long (30 to 50 hours) |
| Onset of Action | Gradual (prevents reflex tachycardia) |
Mechanism of Action
- Calcium Channel Blockade: Amlodipine binds to the L-type calcium channels in the smooth muscles of the arterial walls.
- Inhibition of Ion Influx: It prevents calcium ions from entering the muscle cells, which is the necessary signal for muscle contraction.
- Peripheral Vasodilation: This action results in the relaxation of peripheral arteries, significantly reducing total peripheral resistance and systemic blood pressure.
- Myocardial Oxygen Demand Reduction: By lowering the afterload (the pressure the heart must pump against), it reduces the workload and oxygen consumption of the heart muscle.
- Coronary Vasodilation: It dilates the main coronary arteries and arterioles, increasing oxygen delivery to the myocardium in patients with vasospastic angina.
Key Benefits
- Consistent 24-Hour Control: Its long half-life ensures that blood pressure remains regulated even during the early morning hours when the risk of heart attack is highest.
- Heart Attack & Stroke Prevention: Clinically proven to reduce the risk of major cardiovascular complications associated with high blood pressure.
- Angina Relief: Effectively reduces the frequency of chest pain episodes and increases exercise tolerance in patients with heart disease.
- Gradual Onset: Unlike some other blood pressure medications, Stamlo works gradually, minimizing side effects like sudden dizziness or rapid heartbeat.
- Combination Compatibility: Can be safely used alongside other classes of antihypertensive medications like ACE inhibitors or diuretics for enhanced results.
Precautions
General Precautions
| Condition | Guidance |
|---|---|
| Low blood pressure | Use with caution as it may cause dizziness or excessive BP drop |
| Heart conditions | Inform doctor if you have heart failure or severe aortic stenosis |
| Liver impairment | Dose adjustment may be required in liver disease |
| Pregnancy and breastfeeding | Use only if prescribed by a doctor |
| Elderly patients | May be more sensitive to blood pressure lowering effects |
| Alcohol consumption | Avoid or limit as it may increase dizziness and BP lowering effect |
Medication Use Precautions
- Take exactly as prescribed, preferably at the same time each day
- Do not stop suddenly without medical advice
- Do not double dose if a dose is missed
- Swallow tablet with water, with or without food
- Monitor blood pressure regularly during treatment
Lifestyle Precautions
- Avoid sudden standing up to reduce risk of dizziness
- Maintain a low-salt, heart-healthy diet
- Engage in regular moderate exercise as advised by doctor
- Avoid smoking as it worsens heart and blood pressure conditions
Side Effect Awareness
- May cause swelling in ankles or feet (edema)
- Dizziness or fatigue may occur especially at the beginning of treatment
- Headache or flushing may be experienced in some patients
When to Consult a Doctor
- If blood pressure becomes too low or symptoms of dizziness occur frequently
- If swelling, chest pain, or irregular heartbeat develops
- If side effects persist or worsen over time
- If you are planning pregnancy or have underlying heart disease
Usage
Dosage
The dosage of Stamlo is determined by a healthcare professional based on the patient’s specific condition and response to treatment. For hypertension, the usual starting dose is 5mg once daily, which may be increased to a maximum of 10mg depending on individual needs. For elderly patients or those with liver impairment, a lower starting dose of 2.5mg is often recommended. It is vital to take the tablet at the same time each day to maintain consistent blood levels.
Administration
| Step | Action |
| Timing | Take the tablet once daily, with or without food |
| Method | Swallow the tablet whole with a glass of water |
| Consistency | Try to take the dose at the same time every day (e.g., every morning) |
| Missing a Dose | If missed, take it as soon as possible unless it is almost time for the next dose |
| Continuity | Do not stop taking the medication abruptly without consulting a doctor |
| Monitoring | Regularly check blood pressure to track the effectiveness of the treatment |
Uses
Hypertension Management: Acts as a primary treatment to lower high blood pressure and reduce the strain on the heart and arteries.
Chronic Stable Angina: Used to prevent and reduce the frequency of chest pain episodes in patients with coronary artery disease.
Vasospastic Angina: Treats Prinzmetal’s or variant angina by preventing spasms in the coronary arteries.
Stroke Prevention: Helps decrease the long-term risk of ischemic and hemorrhagic strokes by maintaining healthy blood pressure levels.
Heart Attack Risk Reduction: Lowers the probability of myocardial infarction in patients with existing cardiovascular risk factors.
Kidney Protection: Assists in preventing kidney damage that can be caused by chronic, uncontrolled high blood pressure.
Side Effects
Common Side Effects
- Swelling of ankles or feet (edema)
- Headache
- Dizziness or lightheadedness
- Flushing (feeling of warmth in face or body)
- Fatigue or tiredness
Less Common Side Effects
- Nausea or stomach discomfort
- Palpitations (feeling of fast heartbeat)
- Abdominal pain
- Sleepiness or drowsiness
- Mild muscle cramps
Serious Side Effects
| Side Effect | Description |
|---|---|
| Severe hypotension | Excessively low blood pressure causing fainting or severe dizziness |
| Chest pain worsening | Increased frequency or severity of angina symptoms |
| Irregular heartbeat | Palpitations or abnormal heart rhythm requiring medical attention |
| Severe allergic reaction | Rash, swelling of face/lips, or difficulty breathing |
| Severe swelling | Significant fluid retention in legs or ankles |
Cardiovascular Effects
- May cause mild drop in blood pressure, especially at start of treatment
- Heart rate changes may occur in sensitive individuals
- Rarely, worsening of heart failure symptoms in predisposed patients
When to Stop Use and Consult a Doctor
- If severe dizziness or fainting occurs
- If swelling becomes persistent or worsens
- If chest pain increases or does not improve
- If signs of allergic reaction develop
- If irregular heartbeat or severe fatigue occurs
FAQs
Q: What is Stamlo Tablet?
A: Stamlo Tablet (Amlodipine) is a calcium channel blocker used to treat high blood pressure (hypertension) and angina (chest pain). It works by relaxing and widening the blood vessels, improving blood flow and reducing the workload on the heart.
Q: What is Stamlo Tablet used for?
A: It is used to treat high blood pressure (hypertension), prevent angina (heart-related chest pain), and reduce the risk of heart attacks, strokes, and other cardiovascular complications. It may be prescribed alone or in combination with other blood pressure medications.
Q: How does Stamlo Tablet work?
A: Amlodipine blocks calcium channels in the walls of blood vessels, preventing calcium from entering the cells. This relaxes and widens the blood vessels, allowing blood to flow more easily, lowering blood pressure, and improving oxygen supply to the heart.
Q: How should I take Stamlo Tablet?
A: Take Stamlo Tablet exactly as prescribed by your doctor. It can be taken with or without food, once daily. Take it at the same time every day for best results. Swallow the tablet whole with a glass of water. Do not crush or chew the tablet.
Q: How long does it take to see results?
A: Stamlo Tablet starts working on the day it is taken. However, it may take several weeks to see the full effect on blood pressure. Continue taking the medicine even if you feel well, as high blood pressure often has no visible symptoms.
Q: Can I stop taking Stamlo Tablet on my own?
A: No. Do not stop taking Stamlo Tablet without consulting your doctor. Sudden discontinuation may cause a rapid increase in blood pressure or worsen angina symptoms.
Q: Is Stamlo Tablet safe for children?
A: Stamlo Tablet is not recommended for children under 6 years of age. It may be used for hypertension in children and adolescents aged 6 to 17 years only under medical supervision.
Q: Can it be used during pregnancy or breastfeeding?
A: Stamlo Tablet is not recommended during pregnancy as it may harm the fetus. It may be used during breastfeeding only if clearly necessary and prescribed by a doctor, as Amlodipine may pass into breast milk. Always consult your doctor before use.
Q: What are the possible side effects?
A: Some common side effects may include:
- Headache or dizziness
- Swelling in the ankles or feet
- Fatigue or tiredness
- Nausea or abdominal pain
- Flushing or feeling of warmth
- Sleepiness
Consult your doctor if any side effect persists or worsens.
Q: Can I drink alcohol while taking Stamlo Tablet?
A: Avoid consuming alcohol while taking Stamlo Tablet. Alcohol may lower blood pressure further, increase dizziness, and worsen side effects.
Q: Can I drink grapefruit juice while taking Stamlo Tablet?
A: No. Avoid consuming grapefruit or grapefruit juice while taking Stamlo Tablet as it can increase the concentration of the medicine in the blood and cause unwanted side effects.
Q: Are there any conditions where Stamlo Tablet should not be used?
A: Avoid taking Stamlo Tablet if you have:
- Known allergy to Amlodipine or any of its ingredients
- Very low blood pressure (hypotension)
- Severe aortic stenosis (narrowing of the heart valve)
- Cardiogenic shock or heart failure after a heart attack
Always inform your doctor of your full medical history before starting treatment.
Q: Can Stamlo Tablet be taken with other medicines?
A: Inform your doctor about all medicines and supplements you are currently taking. Some medicines such as Cyclosporin, Rifampicin, Ketoconazole, Simvastatin, and certain antibiotics may interact with Stamlo Tablet and affect its effectiveness or cause side effects.
Q: What should I do if I miss a dose?
A: Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular schedule. Do not take a double dose to make up for a missed one.
Interactions
Drug Interactions
| Medicine Type | Interaction Details |
|---|---|
| Other antihypertensives | May enhance blood pressure lowering effect leading to hypotension |
| Beta blockers | Can increase risk of low heart rate and excessive BP drop |
| Diuretics (water pills) | May further lower blood pressure and increase dizziness risk |
| CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, ritonavir) | Can increase Amlodipine levels, raising side effect risk |
| CYP3A4 inducers (e.g., rifampicin, carbamazepine, phenytoin) | May reduce effectiveness of Amlodipine |
| Simvastatin | Increased risk of muscle-related side effects when used together |
Food and Lifestyle Interactions
- Grapefruit juice may increase Amlodipine levels and side effects
- Alcohol can enhance dizziness and blood pressure lowering effect
- High-salt diet may reduce effectiveness of treatment
- Smoking may worsen cardiovascular health and reduce benefits
Medical Condition Interactions
- Liver disease may require dose adjustment
- Severe heart failure requires careful monitoring
- Low blood pressure conditions may worsen with use
- Peripheral edema may be aggravated in some patients
Other Considerations
- Do not stop or change dose without medical advice
- Monitor blood pressure regularly during treatment
- Inform doctor about all ongoing medications and supplements
When to Seek Advice
- If dizziness, fainting, or very low blood pressure occurs
- If swelling of ankles or feet worsens
- If chest pain or irregular heartbeat develops
- If starting any new prescription or herbal medicines
| Manufacturer | : | Dr. Reddy Lab, India |
| Trade Name | : | Norvasc |
| Generic Search | : | Amlodipine |
| Strength | : | 2.5mg, 5mg, 10mg |
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