Nitrohart Tablet (Isosorbide Dinitrate + Hydralazine)

What is Nitrohart Tablet?

Nitrohart Tablet is a medication that combines two active ingredients, Isosorbide Dinitrate, and Hydralazine. It is primarily used to treat heart failure in patients who cannot take ACE inhibitors or ARBs. The medication works by improving blood flow and reducing the workload on the heart. It is also sold under the brand name BIDIL.
Nitrohart Tablet helps to lower blood pressure and improve blood flow, reducing the strain on the heart and improving the symptoms of heart failure. It is available in tablet form and should be taken exactly as prescribed by a healthcare provider.

Heart failure is a condition where the heart is not able to pump blood effectively, which can lead to symptoms such as shortness of breath, fatigue, and swelling in the legs and feet.

Mechanisum of action Isosorbide Dinitrate and Hydralazine

Isosorbide Dinitrate is a type of vasodilator that works by relaxing and widening the blood vessels in the body, allowing blood to flow more easily. It is commonly used to treat angina (chest pain) caused by coronary artery disease.
Hydralazine is also a vasodilator that works by relaxing the smooth muscles in the blood vessels, which leads to a decrease in blood pressure. It is primarily used to treat high blood pressure (hypertension).

The combination of Isosorbide Dinitrate and Hydralazine in Nitrohart Tablet is used to treat heart failure in patients who cannot take ACE inhibitors or ARBs. It works by improving blood flow and reducing the workload on the heart.

How to use it?

The typical starting dose of Nitrohart Tablet is one tablet taken three times daily. The dose may be adjusted by the healthcare provider based on the patient's response to the medication and any side effects experienced.

Patients should not stop taking Nitrohart tablets without first consulting their healthcare provider. Suddenly stopping the medication can cause an increase in symptoms of heart failure.

Nitrohart Tablet Utilize

It is primarily used to treat heart failure in patients who cannot take ACE inhibitors or ARBs.

Side Effect of Bidil

Some common side effects of the medication include headache, dizziness, lightheadedness, and flushing. These side effects may go away as the body adjusts to the
medication.

Other potential side effects of Nitrohart Tablet may include nausea, vomiting, diarrhea, stomach pain, and loss of appetite. Some patients may also experience an increased heart rate or palpitations.

In rare cases, Nitrohart Tablet can cause more serious side effects, such as anemia, low blood pressure, liver problems, or a condition called a lupus-like syndrome, which can cause joint pain and a rash.

How to reduce the Side Effects

1. Headache: Patients can try taking a pain reliever such as acetaminophen, avoiding alcohol and caffeine, and drinking plenty of water.

2. Dizziness and lightheadedness: Patients can try standing up slowly from a sitting or lying position, avoiding sudden movements, and sitting down if they feel lightheaded.

3. Flushing: Patients can try avoiding hot beverages, spicy foods, and alcohol, and dressing in cool, lightweight clothing.

4. Nausea, vomiting, and diarrhea: Patients can try eating smaller, more frequent meals, avoiding spicy or fatty foods, and drinking plenty of fluids.

5. Increased heart rate or palpitations: Patients should contact their healthcare provider if they experience this side effect, as it may require a dosage adjustment or a change in medication.

Benefits

1. Improved blood flow: Nitrohart Tablet works by widening and relaxing the blood vessels, which improves blood flow and reduces the workload on the heart.

2. Reduced symptoms of heart failure: By improving blood flow and reducing the strain on the heart, Nitrohart Tablet can help alleviate symptoms of heart failure, such as shortness of breath, fatigue, and swelling in the legs and feet.

3. Alternative treatment option: For patients who cannot take ACE inhibitors or ARBs due to side effects or other reasons, Nitrohart Tablet provides an alternative treatment option.

4. Additional benefits for patients with angina: Isosorbide Dinitrate, one of the active ingredients in Nitrohart Tablet, is also used to treat angina (chest pain) caused by coronary artery disease. By relaxing the blood vessels, it can help alleviate symptoms of angina.

5. Additional benefits for patients with hypertension: Hydralazine, the other active ingredient in Nitrohart Tablet, is primarily used to treat high blood pressure (hypertension) by relaxing the smooth muscles in the blood vessels, which leads to a decrease in blood pressure.

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Safety Advice

1. Allergic reactions: Patients with a history of allergic reactions to Isosorbide Dinitrate or Hydralazine should not take Nitrohart tablets.

2. Low blood pressure: Nitrohart Tablet can lower blood pressure, which may cause dizziness or fainting. Patients with low blood pressure or who are taking other medications that lower blood pressure should use Nitrohart Tablet with caution.

3. Liver or kidney problems: Nitrohart tablets may not be suitable for patients with liver or kidney problems, as the medication is eliminated from the body through these organs.

4. Pregnancy and breastfeeding: Nitrohart Tablet is not recommended for use during pregnancy or breastfeeding, as it may harm the developing fetus or newborn.

5. Interactions with other medications: Nitrohart Tablet may interact with other medications, including erectile dysfunction medications, blood pressure medications, and medications that increase blood flow.

6. Lupus-like syndrome: In rare cases, Nitrohart Tablet can cause a condition called a lupus-like syndrome, which can cause joint pain and a rash.

7. Hemodynamic instability: Nitrohart Tablet should be used with caution in patients with hemodynamic instability, as it may further decrease blood pressure.

Concerns

(commonly asked question)

Q: What is Nitrohart Tablet Isosorbide Dinitrate + Hydralazine used for?

A: Nitrohart Tablet Isosorbide Dinitrate + Hydralazine is a combination medication used to treat heart failure and high blood pressure.

Q: How does Nitrohart Tablet Isosorbide Dinitrate + Hydralazine work?

A: Isosorbide dinitrate works by dilating (widening) the blood vessels, which reduces the workload on the heart and improves blood flow. Hydralazine also dilates the blood vessels and lowers blood pressure.

Q: Who should not take Nitrohart Tablet Isosorbide Dinitrate + Hydralazine?

A: Nitrohart Tablet Isosorbide Dinitrate + Hydralazine should not be taken by people who have an allergy to either isosorbide dinitrate or hydralazine, or by those who have severe anemia, glaucoma, or a history of stroke.

Q: How should Nitrohart Tablet Isosorbide Dinitrate + Hydralazine be taken?

A: Nitrohart Tablet Isosorbide Dinitrate + Hydralazine should be taken exactly as prescribed by a healthcare provider. It is usually taken two to four times a day, with or without food.

Q: Can Nitrohart Tablet Isosorbide Dinitrate + Hydralazine be taken during pregnancy or while breastfeeding?

A: Nitrohart Tablet Isosorbide Dinitrate + Hydralazine should only be taken during pregnancy or while breastfeeding if recommended by a healthcare provider, as it may cause harm to a developing fetus or nursing baby.

Q: Can Nitrohart Tablet Isosorbide Dinitrate + Hydralazine be taken with other medications?

A: Nitrohart Tablet Isosorbide Dinitrate + Hydralazine can interact with other medications, so it is important to inform a healthcare provider of all current medications before starting treatment. It should not be taken with medications that treat erectile dysfunction, as this can cause a dangerous drop in blood pressure.

Q: What should be done in case of an overdose of Nitrohart Tablet Isosorbide Dinitrate + Hydralazine?

A: An overdose of Nitrohart Tablet Isosorbide Dinitrate + Hydralazine can cause severely low blood pressure, which can be life-threatening. In case of an overdose, seek emergency medical attention or contact a poison control center immediately.

Drug-drug and drugs-food Reactions

Drug-Drug Interactions:

• Nitrohart Tablet Isosorbide Dinitrate + Hydralazine can interact with other medications that lower blood pressure, such as beta-blockers, calcium channel blockers, and diuretics. This can result in an excessive drop in blood pressure, which can be dangerous.

• It should not be taken with medications used to treat erectile dysfunction, such as sildenafil, tadalafil, and vardenafil, as this can cause a dangerous drop in blood pressure.

• Nitrohart Tablet Isosorbide Dinitrate + Hydralazine can also interact with medications that increase blood flow to the heart, such as nitrates, and with medications that affect the liver, such as rifampin.

Drug-Food Interactions:

• Grapefruit juice can interact with Nitrohart Tablet Isosorbide Dinitrate + Hydralazine and increase the concentration of the medication in the blood, which can cause an excessive drop in blood pressure.

• Alcohol should be avoided or limited while taking Nitrohart Tablet Isosorbide Dinitrate + Hydralazine, as it can increase the risk of side effects, such as dizziness and low blood pressure.