Isentress Tablet (Raltegravir)

Introduction of Isentress Tablet (Raltegravir)

Isentress Tablet, containing the active ingredient Raltegravir, is a medication commonly prescribed for the treatment of human immunodeficiency virus (HIV) infection. As part of highly active antiretroviral therapy (HAART), Isentress Tablet is used in combination with other antiretroviral medications to effectively manage HIV and slow down disease progression. Isentress belongs to a class of drugs known as integrase strand transfer inhibitors, which work by blocking the action of the viral integrase enzyme, preventing viral replication, and reducing the viral load.

Uses of Isentress Tablet (Raltegravir)

Treatment for HIV Infection

Buy Isentress tablets 400mg which are prescribed for the treatment of Human Immunodeficiency Virus (HIV) infection, used in combination with other HIV medications. This combined therapy, known as highly active antiretroviral therapy (HAART), is effective in managing HIV. The virus targets CD4+ cells, which play a crucial role in the immune system's defense against infections. If CD4+ cells are destroyed, it can lead to acquired immune deficiency syndrome (AIDS). Isentress tablets help reduce viral replication, lower the viral load, increase CD4+ cell numbers, and improve immune function, thereby minimizing the risk of disease progression.

Mechanism of Action of Isentress Tablet (Raltegravir)

Isentress tablets 400mg contain raltegravir, an antiretroviral drug classified as an integrase strand transfer inhibitor. Raltegravir inhibits the catalytic activity of HIV integrase, an enzyme required for viral replication. HIV, being a retrovirus, uses reverse transcriptase to transcribe its RNA into DNA. Integrase is another viral enzyme that integrates viral DNA into the host cell genome during early infection. By blocking viral integrase, raltegravir in Isentress tablets 400mg inhibits viral replication, preventing the production of new infectious viral particles. It helps slow down viral replication but does not eliminate the virus already incorporated into CD4+ cells or prevent its transmission to others.

Composition of Isentress Tablet (Raltegravir)

Isentress tablets 400mg contain raltegravir as the active ingredient. In addition, they consist of other ingredients, including microcrystalline cellulose, lactose monohydrate, calcium phosphate dibasic anhydrous, hypromellose 2208, poloxamer 407, sodium stearyl fumarate, and magnesium stearate.

Benefits of Isentress Tablets in HIV Treatment

Isentress tablets 400mg, containing raltegravir, help combat HIV infection. By targeting the viral integrase enzyme, it prevents the destruction of CD4+ cells responsible for immune defense. Without effective treatment, HIV infection can lead to opportunistic and life-threatening infections, including pneumonia, herpes viruses, and Mycobacterium avium complex (MAC) infection. Isentress tablets 400mg, in combination with other HIV medications, inhibit viral replication, reducing the viral load and slowing disease progression. However, they do not eliminate the virus within CD4+ cells or prevent its transmission.

Possible Side Effects of Isentress Tablet (Raltegravir)

Commonly reported side effects of Isentress tablets 400mg include nausea, vomiting, headaches, tiredness, inflammation of the nasal passages and throat, sleep disturbances, upper respiratory tract infection, cough, fever, bronchitis, back pain, and depression. While less common, severe skin reactions such as Stevens-Johnson syndrome and toxic epidermal necrolysis can occur.

Precautions and Contraindications of Isentress Tablet (Raltegravir)

Isentress tablets 400mg should not be used if you are allergic to raltegravir or any of the tablet's ingredients. They are contraindicated during pregnancy and breastfeeding. Additionally, caution should be exercised if you are taking medications that interact with Isentress, such as antacids containing aluminum and/or magnesium or the anti-infective rifampicin.

Dosage and Administration of Isentress Tablet (Raltegravir)

Isentress tablets 400mg should be taken orally with a glass of water, either with or without food. They are usually taken twice daily in combination with other prescribed antiretroviral drugs. It is important to follow your doctor's recommended duration of treatment. Close monitoring is essential to identify and manage any potentially serious side effects, and your doctor may advise discontinuing Isentress tablets 400mg if necessary.

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Duration of Isentress Treatment

The duration of the Isentress tablet treatment should be determined by your doctor's recommendation. Regular monitoring will help evaluate the effectiveness and safety of the medication. If severe side effects occur, your doctor may suggest discontinuing Isentress tablets 400mg.

Missed dose of Isentress

If you miss a dose of Isentress tablets 400mg, take it as soon as you remember, unless it is almost time for the next dose. In such cases, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to compensate for a missed one.

Storage of Isentress Tablets

Isentress tablets 400mg should be stored below 25°C in a cool, dry place, protected from moisture and light.

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Drug Interaction with Isentress Tablet (Raltegravir)

• Isentress Tablets may interact with other medications, potentially affecting their effectiveness or increasing the risk of side effects. It is important to inform your healthcare provider about all the medications you are currently taking, including prescription drugs, over-the-counter medications, and herbal supplements.
• Some medications that may interact with Isentress Tablet include antacids containing aluminum and/or magnesium, which should be taken at least two hours before or six hours after Isentress Tablet to avoid reduced absorption. The anti-infective rifampicin can significantly decrease the levels of Raltegravir in the blood, potentially reducing its efficacy. Therefore, the concurrent use of Isentress Tablet and rifampicin is generally not recommended.
• Additionally, certain anticonvulsants (e.g., phenytoin, carbamazepine) and herbal supplements like St. John's Wort may decrease the levels of Raltegravir in the blood. Conversely, some medications, such as atazanavir, darunavir, and efavirenz, can increase the levels of Raltegravir. Your healthcare provider will consider these potential drug interactions when prescribing Isentress Tablet and may adjust the dose or recommend alternative treatments if necessary.
  
  

FAQs

Q: Can Isentress Tablet (Raltegravir) be used during pregnancy?

A: Isentress Tablet should be used during pregnancy only if specifically recommended by your doctor. It is important to discuss the potential risks and benefits with your healthcare provider, as the safety of this medication during pregnancy is not well-established. Your doctor will consider various factors before deciding on the appropriate treatment options.

Q: Can I drink alcohol while taking Isentress Tablet (Raltegravir)?

A: It is generally recommended to avoid or limit alcohol consumption while taking Isentress Tablet. Alcohol can interact with the medication and may increase the risk of side effects or worsen certain liver conditions that are associated with HIV infection. It is best to consult your healthcare provider regarding the use of alcohol while on the Isentress Tablet.

Q: Can Isentress Tablet (Raltegravir) be used in children?

A: Isentress tablets can be used in children, and the dosage is determined based on their weight and age. It is important to follow your doctor's instructions regarding the appropriate dosage and administration for pediatric patients.

Q: How long do I need to take Isentress Tablet?

A: The duration of Isentress Tablet treatment will depend on various factors, including the severity of your HIV infection and your overall health condition. In most cases, HIV treatment is lifelong, requiring long-term use of antiretroviral medications, including Isentress Tablet. It is important to follow your doctor's instructions regarding the duration of treatment and attend regular follow-up appointments to monitor your response to the medication.

Q: Is Isentress Tablet a cure for HIV infection?

A: Isentress Tablet is not a cure for HIV infection. It is an antiretroviral medication that helps to control the virus and improve the immune function of individuals living with HIV/AIDS. Regular use of Isentress Tablet, along with other prescribed antiretroviral medications, can significantly reduce the viral load and slow down the progression of HIV infection.