Instgra Tablet (Dolutegravir)

Introduction of Instgra Tablet (Dolutegravir)

Instgra tablets contain dolutegravir. Instgra tablets are an antiviral medicine used in the treatment of human immunodeficiency virus (HIV)-1 infection. This medication is an integrative fiber transfer inhibitor. This tablet is to be used only by people over 40 kg or children over 12 years of age. This tablet is always used in combination with other antiviral medicines. This medicine does not cure HIV infection; it only slows down the replication rate of the viral load and thus helps control the disease. Tivicay is another brand name for dolutegravir.

Dolutegravir Tablet manufacturer: Emcure Pharmaceuticals Ltd

Uses of Instgra Tablet (Dolutegravir)

Instgra tablets are antiretroviral drugs of the integrative strand transfer inhibitor family used to treat HIV-1 infection in children over 12 years of age and adults. This tablet is always used in combination with other antiviral medicines. Although the use of dolutegravir sometimes causes resistance, caution is advised and follow-up blood tests are needed to support continued use of this drug.

• • The recommended dose of Instgra (Dolutegravir()) tablets is an oral tablet in combination with other antiretroviral drugs.
• • Instgra tablets can only be used by children over 40 kg
• • Instgra tablets are only used by certain patients 60 years of age and older. Dosage and use are similar to adults. Discuss with your doctor before use.

Side Effects of Instgra Tablet (Dolutegravir/Tivicay)

• Very common side effects occur in more than 1 out of 10 patients: headache, diarrhea, nausea
• Common adverse events occurring in 1/10 patients: rash, pruritus, vomiting, abdominal pain, bloating, insomnia, abnormal dreams, depression, dizziness, fatigue, LFT changes, and increased creatine kinase
• Uncommon side effects in 1/100 of patients: hepatitis, suicidal thoughts and behavior, joint, and muscle pain
• Rare side effect occurs in 1 in 1,000 patients: osteonecrosis

Precautions of Instgra Tablet (Dolutegravir/Tivicay)

WINE

Instgra tablets often cause fatigue, so it is not recommended to take it with alcohol. For other questions, consult your doctor.

DRIVE OR OPERATE MACHINERY

It is best to exercise caution when driving or operating heavy machinery as Instgra tablets cause fatigue. For other questions, consult your doctor.

Pregnancy

The use of Instgra oral tablet causes fetal toxicity and uterine malformations, so caution should be taken.

BEST STORAGE

Instgra oral tablet crosses the placenta and breast milk, so breastfeeding is not recommended while taking this medicine. If you have any questions, consult your doctor

Kidney Problems

Consult your doctor

LIVER FAILURE

Instgra tablets/Tivicay cause abnormal liver function values such as increased GGT. Therefore, it is recommended to monitor closely and after 2 months of treatment monitoring with blood tests for signs of jaundice, every 2 weeks and after 3 months of treatment should have monthly blood tests.

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Interactions with Instgra Tablet (Dolutegravir)

DRUG-DRUG INTERACTIONS

• Increased metabolism by carbamazepine, oxcarbazepine, phenytoin, phenobarbital
• Reduced metabolism by ketoconazole, fluconazole, itraconazole
• Serum concentrations increased by Bisoprolol, Clarithromycin
• Reduced absorption due to magnesium/aluminum-containing antacids

DRUG-FOOD INTERACTIONS

Instgra oral tablet is safe to take with any food, if in doubt please consult your doctor. Instagram tablets often cause fatigue, so it is not recommended to take it with alcohol.

MEDICINE-DISEASE INTERACTIONS

• Liver disorders - use with caution in severe liver disease. Consult your doctor before use
• Renal disorders - Use with caution in severe renal disease. Consult your doctor before use
• Heart disorders - Use with caution in heart failure and myocardial infarction. Consult your doctor before use
• Respiratory disorders - use with caution in case of respiratory failure. Consult your doctor before use
• Blood disorders - use with caution in anemia and thrombocytopenia. Consult your doctor before use

FAQs:-

Are Instgra (Dolutegravir/Tivicay) tablets safe during pregnancy?

No, this medicine shows signs of neural tube defects in the unborn baby. So consult your doctor.

Can I take Instgra while breastfeeding?

There are no specific studies to detail this. But in general, HIV virions can be transmitted through breastfeeding, so it is suspected that HIV antiretroviral drugs can also be transmitted through breastfeeding. So consult your doctor.

Is it possible to use an Instagram tablet while drinking?

The interaction is undefined. So consult your doctor.

Can I take Instgra tablets as monotherapy?

No, Instgra tablets should be used with other antiretrovirals for treatment

Can I use the Instgra tablet while driving or using heavy machinery?

Although there are no direct studies, it's best to remember that Instgra causes side effects that can affect the progress of your labor. So go see your doctor