Endogest SR Tablet (Progesterone) | Used in Menstrual Irregularities, Infertility Treatment, and Pregnancy Care
Endogest SR Tablet is a sustained-release oral supplement containing natural micronized progesterone, used to support female hormonal balance, fertility treatments, and pregnancy maintenance.
Product Overview
Endogest SR Tablet is a high-efficacy hormone replacement therapy (HRT) medication containing Natural Micronised Progesterone. Endogest SR Tablet (Progesterone) treats irregular periods, abnormal uterine bleeding, infertility & supports pregnancy. This sustained-release (SR) formulation is specifically utilized to treat amenorrhea, prevent endometrial hyperplasia, and provide vital support during infertility treatments or early pregnancy maintenance.
Product Composition
- Active Ingredient: Natural Micronised Progesterone
- Formulation Type: Sustained Release (SR) Tablet
- Common Strengths: 200mg, 300mg, 400mg
- Excipients: May include pharmaceutical-grade binders and coating agents (Check packaging for peanut oil warnings in specific batches)
Product Specifications
| Feature | Specification |
| Drug Category | Progestogen / Steroid Hormone |
| Therapeutic Class | Hormone Replacement Therapy (HRT) |
| Release Mechanism | Sustained Release for 24-hour stability |
| Administration | Oral (Swallow whole with water) |
| Recommended Storage | Store in a cool, dry place below 30°C |
Mechanism of Action
- Hormonal Regulation: It supplements the body with exogenous progesterone, mimicking the natural luteal phase of the menstrual cycle.
- Endometrial Support: The medication modulates the growth of the uterine lining, ensuring it is receptive to a fertilized egg for embryo implantation.
- Estrogen Balance: It counteracts the effects of estrogen on the endometrium, significantly reducing the risk of uterine cancer or abnormal thickening.
- Pregnancy Maintenance: By inhibiting uterine contractions, it helps in the prevention of preterm labor and supports the fetus during the first trimester.
Key Benefits
- Menopause Relief: Effectively manages menopausal symptoms like hot flashes and night sweats when used in combination with estrogen.
- Cycle Regularity: Restores a healthy menstrual flow in women suffering from irregular periods or secondary amenorrhea.
- Fertility Enhancement: Provides essential luteal phase support during assisted reproductive technologies (ART) like IVF.
- Miscarriage Prevention: Stabilizes the hormonal environment for women with a history of recurrent pregnancy loss.
- Consistent Efficacy: The sustained-release technology ensures steady hormone levels in the bloodstream, minimizing the "rollercoaster" effect of traditional tablets.
Precautions
Medical supervision
- Use Endogest SR Tablet (Progesterone) only under proper medical supervision
- Do not adjust dose without guidance
- Long term use should be regularly reviewed
- Not suitable for self use without evaluation
Health conditions
| Condition | Precaution |
|---|---|
| Liver disease | Use with caution and monitoring |
| Kidney problems | Dose adjustment may be needed |
| Heart disease | Careful use required |
| Diabetes | Blood sugar may need monitoring |
| History of blood clots | Use with extra caution |
Hormonal effects
- May cause mood changes or breast tenderness
- Can affect menstrual cycle patterns
- Report unusual hormonal symptoms if they persist
Bleeding and cycle changes
- Spotting or irregular bleeding may occur
- Report heavy or prolonged bleeding
- Do not ignore unusual menstrual changes
Use in pregnancy
- Often used in pregnancy support therapy
- Use only as advised during pregnancy
- Regular monitoring may be required
Driving and alertness
- May cause dizziness or drowsiness in some people
- Avoid driving if affected
Monitoring advice
- Regular follow-up may be needed
- Report persistent side effects or worsening symptoms
Usage
Endogest SR Tablet is an advanced hormonal supplement designed for oral administration. The sustained-release technology ensures that the Natural Micronised Progesterone is released gradually, maintaining stable serum progesterone levels throughout the day.
Dosage and Administration
To achieve the best results in hormone therapy, the following administration guidelines should be followed strictly under medical supervision.
Oral Administration: The tablet should be swallowed whole with a glass of water. Do not crush, chew, or break the tablet, as this will destroy the sustained-release mechanism.
Timing: It is highly recommended to take the dose at the same time each day, preferably in the evening or at bedtime, to minimize potential side effects like dizziness or drowsiness.
Dosage for Menopause: When used for HRT (Hormone Replacement Therapy), it is typically taken in a cyclic manner (e.g., 200mg daily for the last 12–14 days of the cycle) or as a continuous daily dose.
Dosage for Amenorrhea: To induce a withdrawal bleed, the standard dose is usually 200mg to 400mg daily for 10 consecutive days.
Food Interaction: For optimal bioavailability, follow your doctor’s advice on whether to take it with or without food, though consistency in your routine is key for hormonal balance.
Missed Dose: If a dose is missed, take it as soon as remembered unless it is almost time for the next dose. Do not double the dose to catch up.
Uses
Endogest SR Tablet serves as a versatile treatment for various gynecological disorders and reproductive health needs by restoring the natural balance of progestogens in the body.
Primary Therapeutic Uses
Hormone Replacement Therapy (HRT): Used in postmenopausal women to prevent endometrial hyperplasia (thickening of the uterus lining) that can be caused by estrogen-only treatments.
Treatment of Secondary Amenorrhea: Indicated for women who have stopped having menstrual periods for several months due to a lack of natural progesterone.
Management of Abnormal Uterine Bleeding: Helps regulate the cycle and control heavy or irregular bleeding caused by hormonal imbalances.
Luteal Phase Support: Crucial for women undergoing infertility treatment or IVF, ensuring the uterine environment is prepared for embryo implantation.
Prevention of Preterm Birth: Prescribed to reduce the risk of premature labor in pregnant women with a short cervix or a history of spontaneous preterm birth.
Endometriosis Management: Sometimes utilized to suppress the growth of endometrial tissue outside the uterus, providing relief from pelvic pain.
Premenstrual Syndrome (PMS): Can be used to alleviate severe PMS symptoms by stabilizing hormone fluctuations in the second half of the cycle.
Side effects
Common side effects
- Headache
- Bloating
- Breast tenderness
- Nausea
- Dizziness
- Mild abdominal discomfort
Menstrual changes
- Irregular bleeding or spotting
- Changes in menstrual flow
- Delayed or early periods
- Temporary cycle imbalance
Hormonal effects
- Mood changes
- Irritability or tiredness
- Weight changes
- Fluid retention
Digestive effects
- Nausea or vomiting
- Constipation or bloating
- Stomach discomfort
Less common effects
- Skin rash or itching
- Sleep changes or drowsiness
- Mild acne flare in some users
Serious effects (rare)
| Serious effect | Possible signs |
|---|---|
| Blood clot risk | Swelling, pain in legs, sudden breathlessness |
| Severe allergy | Rash, swelling, breathing difficulty |
| Severe liver issue | Yellowing of skin/eyes, dark urine |
| Heavy bleeding | Unusual or prolonged vaginal bleeding |
Important warning
- Stop use and seek immediate attention if severe symptoms occur
- Report unusual bleeding or clot-related symptoms quickly
- Regular follow-up may help reduce risks during treatment
FAQs
Q: What is Endogest SR Tablet used for?
A: Endogest SR Tablet is used to treat irregular menstruation, abnormal uterine bleeding, secondary amenorrhea, and female infertility. It is also used as hormone replacement therapy (HRT) in menopausal women and to support early pregnancy.
Q: How does Endogest SR Tablet work?
A: Progesterone works by regulating the growth and shedding of the endometrium (uterus lining), promoting a regular menstrual cycle. It also thickens the uterine wall to support implantation of a fertilised egg and helps maintain early pregnancy.
Q: How should Endogest SR Tablet be taken?
A: Endogest SR Tablet should be taken with or after food, at a fixed time each day, as directed by your doctor. Swallow it whole and do not chew, crush, or break the tablet.
Q: What are the common side effects of Endogest SR Tablet?
A: Common side effects include headache, nausea, vomiting, stomach or abdominal cramps, bloating, dizziness, hair loss, breast pain, irregular vaginal bleeding or spotting, fluid retention, and vaginal yeast infection. Most side effects are mild and resolve on their own. Consult your doctor if they persist or worsen.
Q: Who should not take Endogest SR Tablet?
A: Endogest SR Tablet should not be taken by patients who have or previously had breast cancer, uterine cancer, unexplained vaginal bleeding, or blood clots. Always inform your doctor of your complete medical history before starting this medication.
Q: Can Endogest SR Tablet be used during pregnancy?
A: Endogest SR Tablet is used to support early pregnancy and reduce the risk of threatened abortion and premature labour. However, caution is advised and it should only be taken under a doctor's supervision during pregnancy.
Q: Is Endogest SR Tablet safe for breastfeeding mothers?
A: Consult your doctor before taking Endogest SR Tablet if you are breastfeeding, as your doctor will assess the risks and benefits before recommending its use.
Q: Can Endogest SR Tablet cause dizziness?
A: Yes, Endogest SR Tablet may cause dizziness or drowsiness. Avoid driving or operating heavy machinery until you know how this medicine affects you.
Q: What precautions should be taken before using Endogest SR Tablet?
A: Inform your doctor if you have liver, heart, or kidney problems, diabetes, asthma, epilepsy, or depression before taking this medicine. Your doctor may also advise periodic blood tests and regular physical examinations during treatment.
Q: Can Endogest SR Tablet be used in fertility treatments?
A: Yes, Endogest SR Tablet is commonly used as part of fertility treatments. It helps prepare the uterus for pregnancy by thickening the uterine lining, increasing the chances of successful implantation.
Interactions
Hormonal medicines
- Other hormone therapies may alter the effect of Endogest SR Tablet
- Combined use may increase hormonal side effects
- Dose adjustment may be required
Diabetes medicines
- May affect blood sugar control in some users
- Monitoring of glucose levels may be needed
Liver affecting medicines
- Medicines that affect liver enzymes may change progesterone levels
- Effectiveness may be increased or reduced
Anticonvulsant medicines
- Some seizure medicines may reduce the effect of progesterone
- May require medical review for dose adjustment
Antibiotics and antifungals
- Certain medicines may change hormone metabolism
- Effect may become stronger or weaker
General advice
- Inform about all ongoing medicines before use
- Avoid starting or stopping medicines without guidance
- Regular monitoring may be required during combined therapy
| Manufacturer | : | Cipla Pharma, India |
| Trade Name | : | Prometrium |
| Generic Search | : | Progesterone |
| Strength | : | 200 mg, 300 mg, 400 mg |
Latest Products
