Endace Tablet (Megestrol) | Megace | Used to Treat Advanced Breast and Uterine Cancer, and Weight Loss in Patients with AIDS
Buy Endace 40 mg (Megestrol), Megestrol is a man-made chemical similar to the female hormone progesterone. Megestrol is used to treat loss of appetite and weight loss in people with acquired immunodeficiency syndrome (AIDS). Megestrol is also used in the treatment of advanced breast cancer and endometrial cancer. Megestrol is also sold under the brand name Megace.
Product Overview
Endace Tablet is a specialized hormonal medication used primarily in the management of advanced cancers, such as breast or endometrial cancer. It is also highly effective for treating cachexia, a condition characterized by severe weight loss and muscle wasting, often seen in patients with chronic illnesses. By acting as a synthetic derivative of the natural hormone progesterone, it helps in regulating hormonal imbalances and stimulating appetite to improve the overall quality of life and nutritional status of the patient.
Product Composition
- Active Ingredient: Megestrol Acetate
- Strength: 160 mg (also available in 40 mg variants)
- Excipients: Lactose Monohydrate, Microcrystalline Cellulose, Magnesium Stearate, and Sodium Starch Glycolate
Product Specification
| Feature | Specification |
| Therapeutic Class | Progestin (Antineoplastic) |
| Dosage Form | Oral Tablet |
| Storage | Store below 30°C in a cool, dry place |
| Packaging | Strip or Blister pack |
| Shelf Life | 24 to 36 months from manufacture |
Mechanism of Action
- Hormone Modulation: It works by altering the levels of specific hormones that contribute to the growth of hormone-sensitive tumors, effectively slowing down or stopping cancer cell progression.
- Appetite Stimulation: The medication acts on the central nervous system to increase appetite and food intake, which helps combat significant weight loss.
- Progestogenic Effects: As a progestin, it inhibits the release of pituitary gonadotropins, which leads to a decrease in estrogen production, a key factor in treating breast cancer.
- Metabolic Support: It promotes weight gain by increasing body fat and lean body mass in patients suffering from wasting syndromes.
Key Benefits
- Cancer Management: Highly effective in the palliative treatment of advanced breast and endometrial carcinomas.
- Weight Gain Support: Specifically formulated to help patients regain weight lost due to severe illness or chemotherapy.
- Improved Nutritional Status: Enhances the desire to eat, ensuring patients receive the necessary calories and nutrients for recovery.
- Enhanced Comfort: Helps manage the debilitating symptoms associated with advanced-stage chronic conditions.
Usage
Effective management with Endace Tablet requires precise adherence to the prescribed schedule. This section outlines the typical protocols for integrating this medication into a treatment plan.
Dosage
The quantity of medication is determined by the specific medical condition being addressed. The following guidelines represent standard clinical practices for various indications:
Breast Carcinoma: The standard recommended dose is 160 mg daily, taken either as a single dose or divided into smaller doses throughout the day.
Endometrial Cancer: Treatment typically involves a daily intake ranging from 40 mg to 320 mg, usually administered in divided portions to maintain consistent blood levels.
Appetite and Weight Management: For patients experiencing severe weight loss or anorexia, the dosage is significantly higher, often starting at 400 mg and potentially increasing up to 800 mg per day depending on the patient's nutritional progress.
Dose Adjustments: Reductions or increases may be made by a healthcare professional based on the therapeutic response and the patient’s tolerance over the first few months of treatment.
Administration
Proper intake techniques ensure that the active ingredient, Megestrol, is absorbed efficiently by the body.
| Feature | Guidance |
| Route of Administration | Oral intake only. |
| Timing | Tablets should be taken at the same time every day to ensure a steady concentration in the bloodstream. |
| Food Interaction | May be taken with or without food; however, taking it with a meal may help reduce potential stomach upset. |
| Consumption Method | Swallow the tablet whole with a full glass of water. Do not crush, chew, or break the tablet unless specifically advised. |
| Missed Dose Protocol | Take the missed dose as soon as possible. If it is nearly time for the next dose, skip the missed one and continue the regular cycle. |
Uses
Endace Tablet is a versatile hormonal therapy used to address several serious health concerns through its progestogenic properties.
Palliative Cancer Care: Primarily used to manage symptoms and slow the progression of advanced breast and endometrial cancers when other therapies are not suitable.
Treatment of Cachexia: Effectively treats the "wasting syndrome" characterized by extreme weight loss and muscle atrophy in patients with chronic terminal illnesses.
Appetite Enhancement: Acts as a potent stimulant for patients suffering from medically-induced or disease-related anorexia.
Hormone-Dependent Tumors: Targets specific cells that rely on certain hormones to grow, providing a targeted approach to oncological management.
Nutritional Rehabilitation: Supports recovery by helping the body retain mass and improving the patient's desire to consume essential nutrients.
Side Effects
Common Side Effects
- Increased appetite leading to weight gain
- Fluid retention and swelling in hands or feet
- Nausea or mild stomach discomfort
- Fatigue or feeling unusually tired
- Changes in mood
Serious Side Effects
| Condition | Symptoms to Watch |
|---|---|
| Blood clots | Pain swelling redness in limbs |
| Breathing issues | Shortness of breath chest pain |
| Neurological effects | Sudden severe headache vision changes |
| High blood sugar | Increased thirst frequent urination fatigue |
| Adrenal suppression | Weakness dizziness low energy levels |
Hormonal Related Effects
- Changes in menstrual cycle
- Reduced libido
- Possible hormonal imbalance with long term use
Monitoring
- Regular weight and appetite tracking is recommended
- Blood sugar levels should be checked periodically
- Watch for signs of swelling or fluid retention
- Monitor for any unusual symptoms or sudden health changes
When to Seek Medical Attention
- Difficulty breathing or chest discomfort
- Severe swelling or rapid weight gain
- Persistent vomiting or unusual weakness
- Any signs of allergic reaction such as rash itching or swelling
FAQs
Q: What is the primary purpose of Endace Tablet?
A: This medication is primarily used to treat advanced stages of breast and endometrial cancer. It is also frequently prescribed to manage significant weight loss and loss of appetite in patients with chronic illnesses or those undergoing intensive medical treatments.
Q: How does this medication help with weight gain?
A: The active ingredient acts as an appetite stimulant by interacting with specific pathways in the central nervous system. This helps increase the desire for food, leading to improved caloric intake and a gradual increase in body weight and fat mass.
Q: Is this a steroid medication?
A: No, it is a synthetic derivative of the natural female hormone progesterone. While it is a hormonal medication classified as a progestin, it is not an anabolic steroid.
Q: How long does it take to see results for appetite improvement?
A: While individual responses vary, most patients begin to notice an increase in appetite and nutritional intake within a few weeks of consistent use. Significant weight changes are usually monitored over a period of several months.
Q: Can this medication be used for all types of cancer?
A: No, it is specifically used for hormone-responsive cancers like breast and endometrial cancer. It is not suitable for all cancer types, and its use is determined by the specific hormonal profile of the condition being treated.
Q: What should I do if I miss a dose?
A: If a dose is missed, it should be taken as soon as remembered. However, if it is almost time for the next scheduled dose, the missed one should be skipped to maintain the regular dosing rhythm. Two doses should not be taken at the same time.
Q: Are there specific storage requirements for these tablets?
A: The tablets should be stored in a cool, dry environment where the temperature remains below 30°C. It is important to keep the medication in its original packaging to protect it from moisture and direct light.
| Manufacturer | : | Samarth Pharma, India |
| Trade Name | : | Megace |
| Generic Search | : | Megestrol Acetate |
| Strength | : | 40 mg, 160mg |
Latest Products
