Dolonex DT Tablet (Piroxicam) Used to Relieve Pain, Swelling, and Stiffness
Dolonex DT Tablet contains Piroxicam, a long-acting NSAID used for relieving pain, swelling, and stiffness in joints, muscles, and soft tissues. It blocks COX enzymes to suppress inflammation at its source restoring mobility and comfort in both acute and chronic inflammatory conditions.
Product Overview
Dolonex DT Tablet It contains Piroxicam, a long-acting anti-inflammatory agent from the oxicam family, widely used for moderate to severe pain and swelling in joints, muscles, and the spine. What makes it different from many other anti-inflammatory tablets is its dispersible form. It dissolves in water before you drink it, which is gentler on the stomach and easier to take, especially for those who struggle with swallowing tablets.
How It Works
When any part of your body is injured or inflamed, it releases chemicals called prostaglandins. These are what cause the pain, heat, and swelling you feel. Piroxicam blocks the enzymes (COX-1 and COX-2) that produce these chemicals, reducing inflammation from the inside out.
This gives three layers of relief:
â–¸ Anti-Inflammatory: Calms swelling, redness, and heat in affected joints and tissues
â–¸ Pain Relief: Works both at the site of inflammation and through the body's own pain signalling pathways
â–¸ Fever Reduction: Helps bring down temperature when inflammation causes a mild fever
How the Body Processes It
â–¸ Absorbed well when taken orally; levels in the blood peak within 3 to 5 hours
â–¸ Binds strongly to proteins in the blood (around 99%) for effective distribution to affected areas
â–¸ Broken down by the liver and cleared from the body through the kidneys
â–¸ Half-life of around 50 hours means one daily intake keeps levels stable
Product Specification
| Parameter | Details |
| Active Ingredient | Piroxicam |
| Category | Non-Steroidal Anti-Inflammatory Agent, Oxicam Class |
| Mechanism | COX-1 and COX-2 inhibition, prostaglandin synthesis suppression |
| Onset | Analgesic effect within hours; full anti-inflammatory effect develops over several days |
| Form | Dispersible Tablet |
Key Benefits
â–¸ Targets the Root of Joint Pain: Rather than temporarily numbing pain, Piroxicam reduces the inflammation that is actually causing it, giving more meaningful and lasting relief
â–¸ Gets You Moving Again: Stiffness and swelling are often what limit movement the most. By bringing these down, Dolonex DT helps restore everyday flexibility and range of motion
â–¸ One Intake Covers the Whole Day: With a half-life of around 50 hours, a single daily intake keeps levels stable with no need to watch the clock for the next dose
â–¸ Easier to Take Than a Standard Tablet: The dispersible format is gentler on the stomach and much easier for elderly patients or anyone who finds tablets difficult to swallow
â–¸ Works for the Whole Body: Inflammation rarely stays in one place. Piroxicam works systemically so it addresses swelling and pain across multiple areas at once
Precaution
| Condition | Why It Matters |
| Active stomach ulcer | Piroxicam further irritates the gastric lining and raises bleeding risk |
| Severe heart disease | Prolonged use increases blood pressure and cardiovascular strain |
| Severe kidney impairment | Reduces prostaglandin activity that maintains kidney blood flow |
| Severe liver impairment | Slower breakdown leads to higher blood levels and toxicity risk |
| Asthma | May trigger bronchospasm or allergic respiratory reaction |
Important Precaution Points
Piroxicam can irritate the stomach lining and raise the risk of ulcers and gastrointestinal bleeding, people with a history of stomach ulcers or gastritis should use with care and always take after food
People with existing heart disease require doctor guidance before use as prolonged use can increase cardiovascular strain and raise blood pressure
Piroxicam can reduce blood flow to the kidneys by affecting prostaglandin activity, adequate hydration during use is important to reduce kidney related risk
In people with liver disease, Piroxicam breakdown may be slower increasing side effect risk, rare cases of serious liver reactions including hepatitis and jaundice have been reported
People with asthma or NSAID sensitivity may experience breathing related reactions and should seek doctor guidance before use
Usages
â–¸ Dissolve Completely in Water Before Intake
Place the tablet in approximately 100 ml of water and allow it to dissolve fully before drinking. The tablet should not be swallowed whole or chewed.
â–¸ Take After Food
Dolonex DT should be taken after a meal or light snack. Intake on an empty stomach increases the likelihood of gastric irritation, which is a known consideration with anti-inflammatory agents of this class.
â–¸ Once Daily at a Consistent Time
Take once per day at the same time each day. The long half-life of Piroxicam ensures that a single daily intake is sufficient to maintain effective blood levels throughout the 24-hour period.
â–¸ Maintain Adequate Hydration
Sufficient daily fluid intake supports kidney function during the course of use, particularly during extended periods of anti-inflammatory intake.
â–¸ Complete the Full Recommended Course
Continue taking Dolonex DT for the full duration recommended by your doctor, even if symptoms improve before the course ends. Stopping early may result in incomplete resolution of the underlying inflammation and a return of symptoms.
Uses
Dolonex DT Tablet is used for a broad range of inflammatory, arthritic, and musculoskeletal pain conditions.
â–¸ Rheumatoid Arthritis
Rheumatoid arthritis is an autoimmune condition in which the immune system attacks the synovial lining of joints, causing chronic inflammation, joint swelling, pain, and progressive structural damage.
â–¸ Osteoarthritis
Osteoarthritis involves the gradual breakdown of articular cartilage in joints, most commonly affecting the knees, hips, hands, and lumbar spine.
â–¸ Ankylosing Spondylitis
Ankylosing spondylitis is a chronic inflammatory condition primarily affecting the sacroiliac joints and spine.
â–¸ Cervical Spondylitis and Neck Pain
Cervical spondylitis involves inflammation of the cervical spine and surrounding structures. It presents as neck stiffness, restricted neck movement, and pain that can radiate into the shoulders and arms.
â–¸ Back Pain and Lumbar Conditions
A significant proportion of back pain cases involve an underlying inflammatory component, whether from muscular strain, intervertebral disc irritation, or structural spinal conditions. Piroxicam addresses this inflammatory component rather than only suppressing the pain signal.
â–¸ Muscle Pain and Musculoskeletal Injuries
Sprains, muscle strains, and overuse injuries trigger a localised inflammatory response involving prostaglandin release. Piroxicam reduces this response at the injury site, addressing the cause of pain rather than simply masking it, and supporting normal tissue recovery.
â–¸ Post-Traumatic and Post-Operative Pain
Physical trauma and surgical procedures generate significant prostaglandin activity that drives post-injury and post-operative pain and swelling.
â–¸ Bursitis, Tendinitis and Soft Tissue Inflammation
Inflammatory conditions of soft tissues surrounding joints, including bursitis (inflammation of bursae), tendinitis (inflammation of tendons), and periarticular inflammation, respond well to Piroxicam's systemic anti-inflammatory action.
Side Effects
Dolonex DT Tablet is generally well tolerated when used as directed. However, like all anti-inflammatory agents, it may cause certain side effects in some people.
Common Side Effects
- Stomach pain and acidity due to gastric irritation from Piroxicam
- Nausea or vomiting, particularly when taken on an empty stomach
- Heartburn and indigestion from increased gastric acid activity
- Dizziness or lightheadedness, especially in the initial days of use
- Bloating or general stomach discomfort during the course of use
Less Common Side Effects
- Mild headache, usually temporary and reduces with continued use
- Skin rash or itching in sensitive individuals
- Fluid retention and swelling particularly in the ankles and feet
- Fatigue or general tiredness during extended use
Serious Side Effects
| Side Effect | What to Watch For |
| Gastrointestinal bleeding | Black or tarry stools, vomiting blood, or severe stomach pain |
| Stomach ulcers | Persistent burning pain in the stomach, particularly on an empty stomach |
| Kidney function changes | Reduced urine output or unusual swelling in the legs and ankles |
Important Side Effect Advice
- Taking Dolonex DT after food significantly reduces the risk of stomach related side effects including acidity, nausea, and gastric irritation
- Mild effects such as nausea, headache, or dizziness often settle on their own as the body adjusts in the initial days of use
- Staying well hydrated throughout the course of use supports kidney function and reduces the risk of kidney related complications
- Most side effects are dose related, using the amount directed by a doctor and for the recommended duration keeps the risk low
FAQs
Q. What is Dolonex DT used for?
Used for pain, swelling, and inflammation in joints and muscles in conditions such as arthritis, back pain, and ankylosing spondylitis.
Q. How does it work?
Blocks COX-1 and COX-2 enzymes that produce prostaglandins, reducing inflammation and pain throughout the body.
Q. How should it be taken?
Dissolve fully in water and take after a meal, once daily at the same time each day.
Q. How long does it take to work?
Pain relief within a few hours. Full anti-inflammatory effect in chronic conditions develops over several days to weeks.
Q. What is the most common side effect?
Stomach acidity, nausea, and heartburn. Risk is significantly reduced by taking after food.
Q. Can it cause stomach bleeding?
Yes, particularly with prolonged use. Black stools or severe stomach pain are warning signs requiring immediate attention.
Q. Does it affect kidney function?
Extended use can affect kidney function. Staying well hydrated during use helps reduce this risk.
Q. Can it be taken with alcohol?
Alcohol raises stomach bleeding risk and amplifies dizziness during use. It should be avoided throughout the course.
Q. Is it safe during pregnancy?
Use during pregnancy particularly in the last three months carries serious risks. Always consult a doctor before use.
Q. What to do if a side effect occurs?
Mild effects often settle with continued use after food. Persistent or serious symptoms should be discussed with a doctor without delay.
Interaction
| Substance | Effect on the Body |
| Warfarin and anticoagulants | Piroxicam prolongs bleeding time, combined use significantly raises internal bleeding risk |
| Other NSAIDs and Aspirin | Multiplies the risk of stomach ulcers and gastrointestinal bleeding with no added benefit |
| Methotrexate | Slows Methotrexate elimination, raising blood levels to potentially harmful concentrations |
| Alcohol | Raises gastric bleeding risk and amplifies dizziness and drowsiness |
| Corticosteroids | Combined use further raises the risk of stomach ulceration and gastrointestinal bleeding |
Important Interaction Advice
Taking Piroxicam alongside anticoagulants such as Warfarin significantly increases internal bleeding risk as Piroxicam independently prolongs bleeding time and compounds the anticoagulant effect
Combining with other anti-inflammatory agents or aspirin multiplies stomach ulcer and bleeding risk without providing any additional anti-inflammatory benefit
Piroxicam slows Methotrexate elimination from the body, raising its blood levels to harmful concentrations and increasing the risk of serious effects including nausea, mouth sores, and liver toxicity
Piroxicam reduces kidney clearance of Lithium leading to higher Lithium blood levels and increased toxicity risk, levels should be monitored carefully if both are used together
Reduces the effectiveness of ACE inhibitors, beta-blockers, and diuretics which can result in reduced blood pressure control and increased kidney stress
| Manufacturer | : | Pfizer Ltd, India |
| Trade Name | : | Feldene |
| Generic Search | : | Piroxicam |
| Strength | : | 20 mg |






















