Dermifree Super Plus (Ofloxacin + Ornidazole + Itraconazole + Clobetasol Propionate)
Dermifree Super Plus cream is used to treat various skin infections involving bacteria and fungi. It is a combination of Ofloxacin, Ornidazole, Itraconazole, and Clobetasol Propionate which treat fungal infections, bacterial infections, and inflammatory skin conditions.
Product Overview
Dermifree Super Plus cream is a multi-component topical cream designed for the comprehensive management of complex skin infections. This formulation combines four active ingredients to target a broad spectrum of pathogens and inflammation: Ofloxacin (a fluoroquinolone antibiotic) fights bacterial infections, Ornidazole (an antiprotozoal agent) targets anaerobic bacteria and specific parasites, Itraconazole (an antifungal) treats fungal infections, and Clobetasol Propionate (a potent corticosteroid) provides rapid relief from itching, redness, and inflammation. By addressing multiple causes of skin irritation simultaneously, this cream is highly effective for complicated skin conditions that involve mixed infections or severe inflammatory responses.
Product Composition
- Ofloxacin
- Ornidazole
- Itraconazole
- Clobetasol Propionate
- Cream base excipients
Product Specification
| Feature | Details |
| Brand Name | Dermifree Super Plus |
| Category | Multi-purpose topical cream (antibacterial, antiprotozoal, antifungal, anti-inflammatory) |
| Form | Cream |
| Indication | Complex skin infections and associated inflammation |
| Storage Conditions | Store in a cool, dry place; avoid freezing and direct sunlight |
Mechanism of Action
- Ofloxacin: Inhibits bacterial DNA gyrase, stopping bacterial replication.
- Ornidazole: Disrupts the DNA structure of susceptible protozoa and anaerobic bacteria.
- Itraconazole: Inhibits the synthesis of ergosterol, an essential component of fungal cell membranes, leading to fungal cell death.
- Clobetasol Propionate: Suppresses the immune response at the site of application to reduce swelling, redness, and intense itching.
Key Benefits
- Provides a "four-in-one" solution for mixed skin infections
- Offers rapid symptomatic relief from intense itching and burning sensations
- Reduces inflammation quickly, helping to calm irritated skin
- Simplifies treatment by addressing bacterial, fungal, and parasitic components simultaneously
Precautions
General Precautions
| Precaution | Details |
|---|---|
| External Use Only | Apply only on affected skin; do not ingest |
| Avoid Sensitive Areas | Keep away from eyes, face, groin, and mucous membranes unless prescribed |
| Short Term Use | Use only for prescribed duration due to steroid content |
| Thin Layer Application | Apply a small amount; avoid overuse |
| Hand Hygiene | Wash hands before and after application |
Skin Safety Precautions
- Do not apply on open wounds, cuts, or severely damaged skin
- Avoid covering treated area with airtight dressings unless advised
- Discontinue use if severe irritation, burning, or allergic reaction occurs
- Prolonged use may cause skin thinning or other steroid related effects
Special Precautions
- Use only under medical supervision due to multiple active ingredients
- Not recommended for long term or cosmetic use
- Avoid use in children unless prescribed
- Consult a doctor before use during pregnancy or breastfeeding
Infection Related Precautions
- Use only for confirmed mixed bacterial or fungal infections
- Avoid unnecessary or prolonged use to prevent resistance
- Do not share the medication with others
Storage Precautions
- Store in a cool and dry place
- Protect from direct sunlight and heat
- Close tube tightly after use
- Keep out of reach of children
Usage
Dosage
Apply a thin layer of the cream to the affected area once or twice daily, or as strictly prescribed by your healthcare professional.
Administration
| Instruction | Method |
| Preparation | Clean and thoroughly dry the affected area before application |
| Application | Gently apply a small amount of cream to cover the affected skin |
| Technique | Wash hands before and after applying the cream to prevent spreading the infection |
| Consistency | Use only for the duration specified by your doctor to avoid side effects from the corticosteroid component |
Uses
Management of complex, mixed skin infections
Treatment of inflammatory skin conditions accompanied by secondary infections
Relief from symptoms of itching, redness, and swelling caused by fungal or bacterial presence
Targeted care for persistent skin irritation that has not responded to single-agent treatments
Side Effects
Common Side Effects
- Mild burning or stinging sensation
- Redness at the application site
- Itching or irritation
- Dryness of skin
- Temporary relief followed by mild discomfort
Less Common Side Effects
- Skin thinning with prolonged use
- Stretch marks or visible blood vessels
- Increased hair growth at application site
- Skin discoloration or lightening
- Delayed wound healing
Serious Side Effects
| Serious Side Effect | Description |
|---|---|
| Severe allergic reaction | Rash, swelling, or hypersensitivity response |
| Skin atrophy | Thinning of skin due to prolonged steroid use |
| Secondary infection | Increased risk of bacterial or fungal overgrowth |
| Hormonal effects | Rare systemic absorption leading to steroid related effects |
| Worsening infection | Spread or aggravation of untreated or resistant infection |
Monitoring
- Monitor for redness, irritation, or worsening of symptoms
- Watch for signs of skin thinning or discoloration with prolonged use
- Discontinue use if severe allergic reaction occurs
- Consult a doctor if infection does not improve or worsens
FAQs
Q: What is the product used for?
A: Dermifree Super Plus is used to treat mixed skin infections where bacterial, fungal, or protozoal pathogens are present alongside significant inflammation. It is commonly prescribed for infected eczema, severe dermatitis, and complex fungal infections that have become red, swollen, and itchy.
Q: Can I use this cream for a common diaper rash?
A: No. Due to the high potency of Clobetasol Propionate, this cream should not be used on infants or for diaper rashes. Corticosteroids can be absorbed more easily through an infant's skin, potentially causing systemic side effects.
Q: Is this cream effective for viral infections like cold sores or shingles?
A: No, this product contains antibacterial and antifungal agents, but it does not contain antiviral medication. Applying a potent steroid to a viral infection may actually make the infection worse.
Q: Can I use Dermifree Super Plus for acne?
A: You should avoid using this cream for acne. While it may temporarily reduce redness, the steroid component (Clobetasol) can actually trigger or worsen a specific type of breakout known as "steroid-induced acne."
Q: How soon should I expect to feel relief?
A: The corticosteroid component (Clobetasol) usually begins reducing itching and redness within a few hours to a couple of days. However, you must complete the full course as prescribed to ensure the underlying bacteria or fungi are fully eradicated.
Q: Does this cream cause skin lightening?
A: While steroids can sometimes cause temporary lightening of the skin (hypopigmentation), this is usually a side effect of prolonged or improper use. If you notice any unusual changes in skin color, contact your dermatologist.
Q: What should I avoid while using this product?
A: Avoid getting the cream in your eyes, nose, or mouth. Additionally, avoid using other skin products (like harsh soaps, chemical peels, or other medicated creams) on the same area unless approved by your doctor, as this may increase irritation.
Q: Can I use this for long-term treatment?
A: No. Because this product contains a potent corticosteroid (Clobetasol), it should only be used for the short duration recommended by your doctor to avoid skin thinning and other side effects.
Q: Should I apply this to broken or open skin?
A: Consult your doctor before applying this cream to open wounds, severe cuts, or raw skin, as systemic absorption may increase.
Q: Can I use this on my face?
A: You should generally avoid using potent corticosteroids like Clobetasol on the face, groin, or underarms unless specifically instructed by a dermatologist, as the skin in these areas is more prone to thinning.
Q: What should I do if I don't see improvement?
A: If symptoms do not improve after a few days of use, or if they worsen, stop using the product and consult your healthcare professional for a re-evaluation of the diagnosis.
Q: Is it okay to bandage the area after application?
A: Do not cover, bandage, or wrap the treated area unless specifically directed by your doctor, as this can increase the absorption of the medication and the risk of side effects.
Interactions
Drug Interactions
| Drug / Product Type | Interaction Details |
|---|---|
| Other Topical Steroids | Increased risk of skin thinning, irritation, and steroid-related side effects |
| Topical Antibiotics | May increase irritation or alter antibacterial effectiveness when combined |
| Antifungal Creams | Concurrent use may not provide added benefit and can increase skin sensitivity |
| Topical Retinoids | Can cause excessive dryness, irritation, and peeling if used together |
| Oral Antibiotics or Antifungals | Generally safe but should be used under medical supervision |
Topical Product Interactions
- Avoid applying multiple medicated creams on the same area unless prescribed
- Do not mix with strong antiseptics or irritant topical agents
- Layering products may reduce effectiveness or increase irritation
Skin Care Product Interactions
- Avoid alcohol-based products, harsh soaps, and fragranced skincare items
- Strong chemical-based products may worsen skin irritation
- Use mild, non-irritating skincare during treatment
Condition Based Interactions
- In sensitive skin or conditions like eczema, use only under strict medical guidance
- Avoid use on severely inflamed, infected, or broken skin unless advised
- May interact with ongoing dermatological procedures such as chemical peels or laser treatments
Steroid Related Interaction Considerations
- Prolonged use with other steroid-containing products increases risk of systemic absorption
- May suppress local immune response, increasing risk of secondary infections
- Careful monitoring required when used with other immunosuppressive treatments
| Manufacturer | : | Healing Pharma |
| Trade Name | : | |
| Generic Search | : | Ofloxacin + Ornidazole + Itraconazole + Clobetasol Propionate |
| Strength | : | 15gm |
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