Deriva-CMS Gel (Adapalene + Clindamycin) | Topical Gel for Acne Treatment and Bacterial Skin Infections
Deriva-CMS Gel is used for treating and managing acne. It contains two medications, Clindamycin and Adapalene. Clindamycin is an antibiotic that inhibits the growth of bacteria causing pimples, while Adapalene is a medication derived from vitamin A that reduces inflammation and prevents the formation of blemishes due to the accumulation of oil and dirt. When using this gel, avoid excessive use of makeup and other products on your skin. Pregnant and breastfeeding women should also avoid using adapalene clindamycin gel. It is important not to pop acne as it can spread bacteria and pus on the skin, leading to the development of acne scars.
Product Overview
Deriva-CMS Gel is a dermatologically formulated combination treatment designed to manage acne vulgaris, including persistent blackheads, whiteheads, and inflammatory lesions. By merging the exfoliating and cell-normalizing properties of a retinoid with the bacteria-fighting power of an antibiotic, this gel targets the root causes of breakouts. It works by regulating skin cell turnover to prevent pore blockages while simultaneously inhibiting the growth of acne-causing microorganisms. With consistent use, the gel helps to reduce inflammation, minimize painful swellings, and promote a clearer, smoother complexion over several weeks. It is specifically engineered to treat the underlying factors that contribute to skin eruptions, making it an essential component for those seeking effective control over acne-prone skin.
Product Composition
- Adapalene 0.1 percent w/w
- Clindamycin 1 percent w/w
- Carbomer
- Methylparaben
- Propylene glycol
- Purified water
Product Specification
| Feature | Details |
| Brand Name | Deriva-CMS |
| Category | Anti-acne medication |
| Ingredients | Adapalene and Clindamycin |
| Form | Topical Gel |
| Skin Type | Acne-prone skin |
Mechanism of Action
- Adapalene acts as a retinoid that normalizes the skin cell turnover process, which helps to unclog pores and prevent the formation of new microcomedones
- Clindamycin is a lincosamide antibiotic that inhibits bacterial protein synthesis, effectively reducing the load of acne-causing bacteria on the skin surface
- The combined action significantly decreases inflammation and swelling associated with infected skin lesions
- The gel base facilitates even distribution and penetration of the active compounds into the dermal layers for targeted treatment
Key Benefits
- Dual-action formula tackles both bacterial growth and pore blockage simultaneously
- Helps reduce the appearance of blackheads, whiteheads, and painful inflammatory pimples
- Improves overall skin texture and tone with regular, long-term application
- Targeted treatment for managing moderate to severe acne breakouts
- Supports the healing of existing lesions while preventing the development of new acne spots
Precautions
General Precautions
| Precaution | Details |
|---|---|
| External Use Only | Apply only on affected skin; do not ingest or use internally |
| Avoid Sensitive Areas | Keep away from eyes, lips, mouth, and mucous membranes |
| Sun Exposure | Limit sun exposure and use sunscreen as Adapalene may increase photosensitivity |
| Proper Use | Apply a thin layer as directed; avoid excessive application |
| Hand Hygiene | Wash hands before and after applying the gel |
Skin Safety Precautions
- Do not apply on broken, cut, or severely irritated skin
- Avoid waxing or abrasive skincare treatments on treated areas
- Use gentle, non-comedogenic skincare products during treatment
- Temporary dryness or irritation may occur initially
Special Precautions
- Use cautiously in individuals with sensitive or eczema-prone skin
- Consult a doctor before use during pregnancy or breastfeeding
- Not recommended for children unless prescribed
- Avoid combining with other strong acne treatments without medical advice
Lifestyle Precautions
- Avoid excessive sun exposure and tanning beds
- Do not pick or squeeze acne lesions during treatment
- Maintain proper skin hygiene for better results
Storage Precautions
- Store in a cool and dry place
- Keep away from direct sunlight and heat
- Close tube tightly after use
- Keep out of reach of children
Usage
Dosage
Apply a thin layer of Deriva-CMS Gel to the affected skin area once daily, preferably in the evening, or as directed by a healthcare professional.
Administration
| Instruction | Method |
| Preparation | Wash the affected area with a mild cleanser and pat dry thoroughly before application |
| Application | Apply a pea-sized amount of gel specifically to the areas affected by acne |
| Technique | Gently spread the gel over the skin surface until fully absorbed |
| Safety | Avoid contact with eyes, nose, mouth, and other sensitive mucous membranes |
Uses
Treatment and management of acne vulgaris
Reduction of inflammatory skin lesions and pustules
Prevention of new blackhead and whitehead formation
Improvement of skin clarity in acne-prone individuals
Side Effects
Common Side Effects
- Dry skin at the application site
- Mild redness or irritation
- Burning or stinging sensation
- Peeling or flaking of skin
- Increased skin sensitivity
Less Common Side Effects
- Itching or discomfort
- Temporary worsening of acne during initial use
- Mild skin inflammation
- Oiliness changes in skin
Serious Side Effects
| Serious Side Effect | Description |
|---|---|
| Severe skin irritation | Intense redness, burning, or discomfort that does not improve |
| Allergic reaction | Rash, swelling, or hypersensitivity on treated skin |
| Severe peeling | Excessive flaking with pain or discomfort |
| Photosensitivity reaction | Severe sunburn-like reaction after sun exposure |
| Worsening infection | Significant increase in acne or skin inflammation |
Monitoring
- Monitor skin for dryness, redness, or irritation during early treatment
- Watch for excessive peeling or discomfort after application
- Discontinue use if severe reactions occur
- Consult a doctor if acne worsens significantly or does not improve with time
FAQ
Q: Can I use this gel during the day?
A: It is generally recommended to use this gel in the evening as directed, and you should always follow up with sun protection, as the ingredients may increase skin sensitivity to sunlight.
Q: Is it normal to experience skin peeling or redness?
A: Yes, mild peeling, redness, and dryness are common during the initial stages of treatment as the skin adjusts to the retinoid component.
Q: Can I apply makeup over this gel?
A: You may apply makeup, but it is recommended to use non-comedogenic products and allow the gel to fully absorb into the skin before applying any other cosmetics.
Q: How long does it take to see results?
A: While individual results vary, consistent daily use over several weeks is typically required to notice significant improvements in acne clearance.
Q: Should I continue using the gel after my acne clears?
A: You should consult your doctor regarding the duration of treatment; it is often recommended to continue using the product to maintain clear skin and prevent future breakouts.
Interactions
Drug Interactions
| Drug / Product Type | Interaction Details |
|---|---|
| Topical Retinoids | Increased irritation, redness, and skin peeling when combined |
| Other Topical Antibiotics | May increase skin dryness or alter effectiveness |
| Benzoyl Peroxide | Can be used in combination, but may increase dryness and irritation |
| Corticosteroid Creams | May reduce effectiveness of acne treatment or alter skin response |
| Oral Antibiotics for Acne | Generally safe, but should be used under medical supervision |
Topical Product Interactions
- Avoid using multiple acne treatments simultaneously without medical advice
- Do not layer with strong exfoliating agents like AHAs, BHAs, or scrubs
- Combining with harsh medicated ointments may increase irritation
Skin Care Product Interactions
- Avoid alcohol-based toners, astringents, or harsh cleansers
- Fragranced or irritating skincare products may worsen dryness
- Use mild, non-comedogenic moisturizers to reduce irritation
Condition Based Interactions
- In sensitive or eczema-prone skin, use only under medical guidance
- Avoid use on severely inflamed or broken skin unless advised
- May interact with skin undergoing aggressive dermatological treatment
Sun Exposure Interaction
- Increased sensitivity to sunlight; avoid excessive sun exposure
- Use sunscreen daily during treatment to prevent irritation and pigmentation changes
| Manufacturer | : | Glenmark Pharma, India |
| Trade Name | : | |
| Generic Search | : | Adapalene + Clindamycin |
| Strength | : | 15gm (0.1% w/w + 1% w/w) |
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