Crizalk Capsule (Crizotinib)

Introduction of Crizotinib Capsule (Crizalk)

Crizotinib, marketed under the brand name Crizalk, is a medication used in the treatment of certain types of cancer. It belongs to a class of drugs called tyrosine kinase inhibitors (TKIs), which work by blocking the action of specific proteins involved in the growth and spread of cancer cells. Xalkori is the brand name for Crizotinib in the United States. It is the same medication as Crizalk, and both contain Crizotinib as the active ingredient. Xalkori is widely prescribed for the treatment of ALK-positive metastatic NSCLC and ROS1-positive NSCLC.

Dosage Information:

The dosage of the Crizotinib Capsule may vary depending on the individual and the type of cancer being treated. It is important to follow the instructions provided by your healthcare provider or pharmacist. Crizotinib is usually taken orally in the form of capsules, and it can be taken with or without food.

Uses of Crizotinib Capsule:

Crizotinib is primarily used in the treatment of non-small cell lung cancer (NSCLC) that is caused by a specific gene mutation known as anaplastic lymphoma kinase (ALK) rearrangement. It is also indicated for the treatment of metastatic NSCLC with ROS1 gene rearrangement. Crizotinib has shown significant efficacy in shrinking tumors and delaying disease progression in patients with these specific genetic alterations. Additionally, Crizotinib may be used in clinical trials or off-label for the treatment of other cancers or conditions, as determined by healthcare professionals. It is important to consult with a qualified healthcare provider to understand the potential benefits and risks of using Crizotinib in specific cases.

Crizotinib Cost: The cost of Crizotinib may vary depending on factors such as the country, dosage strength, and the specific brand being purchased. Pricing for medications can differ across pharmacies and online platforms.& Buy Crizotinib Capsule at onlinegenericmedicine.com to get the best price and discount.
Crizotinib Capsule Manufacturer: Crizotinib Capsules are manufactured by various pharmaceutical companies worldwide. Some well-known manufacturers include Pfizer Inc., which produces Xalkori, and other generic manufacturers that produce Crizotinib under different brand names. It is important to ensure that you obtain Crizotinib from a reputable manufacturer to ensure quality and safety.

Side Effects of Crizotinib Capsule (Crizalk)

• Gastrointestinal Effects
• Fatigue and Weakness
• Lung Problems
• Edema
• Changes in Liver Function
• Visual Disturbances
• Cardiac Effects
  
  

Precautions of crizotinib Capsule (Crizalk)

Allergies: Inform your healthcare provider if you have any known allergies to Crizotinib or any other medications. This is important to prevent the occurrence of allergic reactions or other adverse effects.

Liver and Kidney Function: Crizotinib is metabolized in the liver and excreted through the kidneys. Therefore, individuals with impaired liver or kidney function may require dosage adjustments or closer monitoring to ensure safe and effective use of the medication.

Heart Conditions: Crizotinib may cause certain heart-related side effects, such as irregular heartbeats, changes in the electrical activity of the heart, and even heart failure. Inform your healthcare provider if you have a history of heart problems or any pre-existing cardiac conditions.

Lung Problems: Crizotinib may lead to lung-related adverse effects, including inflammation of the lung tissue (pneumonitis) and lung infections. It is important to report any new or worsening respiratory symptoms, such as shortness of breath, cough, or chest pain, to your healthcare provider.

Vision Changes: Some individuals may experience visual disturbances while taking Crizotinib. If you notice any changes in your vision, such as blurred vision or sensitivity to light, inform your healthcare provider.

Pregnancy and Breastfeeding: Crizotinib may harm the developing fetus, so it is important to use effective contraception during treatment and avoid becoming pregnant. It is also not recommended to breastfeed while taking Crizotinib due to the potential risks to the infant.

Drug Interactions with Crizotinib Capsule (Crizalk)

CYP3A Inhibitors and Inducers: Crizotinib is metabolized by the CYP3A enzyme system in the liver. Co-administration of Crizotinib with strong CYP3A inhibitors (e.g., ketoconazole, clarithromycin) may increase the blood levels of Crizotinib, leading to a higher risk of adverse effects. Conversely, co-administration with strong CYP3A inducers (e.g., rifampin, carbamazepine) may reduce the effectiveness of Crizotinib. Inform your healthcare provider about all medications you are taking, including over-the-counter drugs and herbal supplements. Crizotinib may prolong the QT interval, which increases the risk of abnormal heart rhythms. Therefore, caution should be exercised when combining Crizotinib with other medications that also prolong the QT interval, such as certain antiarrhythmics, antipsychotics, and antidepressants. The absorption of Crizotinib may be reduced when taken with antacids containing aluminum, magnesium, or calcium. To ensure optimal absorption, it is advisable to separate the administration of Crizotinib and antacids for several hours.

FAQs

Crizotinib Capsule (Crizalk)

Can Crizotinib Capsule (Crizalk) be taken with food?

Yes, Crizotinib Capsule can be taken with or without food. However, it is important to follow the instructions provided by your healthcare provider or pharmacist regarding the specific dosing recommendations for Crizotinib in your case.

Is it safe to drive or operate machinery while taking Crizotinib Capsule/Xalkori?

Crizotinib may cause fatigue and weakness, which can impair your ability to drive or operate machinery. It is advisable to exercise caution and assess your individual response to the medication. If you experience significant fatigue or weakness, it is recommended to refrain from driving or operating machinery until the extent of these side effects is known.

Can Crizotinib Capsule (Crizalk) be used in pediatric patients?

The use of Crizotinib in pediatric patients is generally not recommended. The safety and effectiveness of Crizotinib in children have not been well established. The medication is primarily indicated for specific types of cancer in adults, and its use in pediatric populations should be carefully evaluated by a qualified healthcare provider.

Are there any specific monitoring requirements while taking Crizotinib Capsule?

Yes, regular monitoring of liver function tests and cardiac function may be necessary during treatment with Crizotinib. This is to ensure that the medication is well-tolerated and to detect any potential adverse effects on the liver or heart. Your healthcare provider will determine the appropriate monitoring schedule based on your individual circumstances.