Endogest Capsule (Progesterone (Natural Micronized)

Uses & Effectiveness?

Likely Effective for

• Absence of menstrual periods (amenorrhea). Taking progesterone orally and applying progesterone gel into the vagina are effective strategies for treating the absence of menstrual periods in premenopausal women. Micronized progesterone is FDA-accepted for this use, as is intravaginal progesterone gel (Crinone 4%).
• Hormone replacement therapy (HRT). Micronized progesterone (Prometrium) is FDA-approved to be used with estrogen as a component of HRT. Research shows that adding progesterone to HRT safeguard against side effects of estrogen.
• incompetence to become pregnant within a year of trying to conceive (infertility). Intravaginal progesterone gel (Crinone 8%) is FDA-approved to be used as a neighborhood of infertility treatment in women. Some research advises that applying progesterone intravaginally and injecting it into the muscle may have similar effectiveness for increasing pregnancy rates as giving it orally. Also, research suggests that intravaginal progesterone seems to be as compelling for pregnancy rates as human chorionic gonadotropin (HCG).

Possibly Effective for

• Abnormal thickening of the liner of the uterus (endometrial hyperplasia). Some research advises that applying progesterone (Crinone) into the vagina prevents endometrial hyperplasia in women with an intact uterus that is taking estrogen replacement therapy. Other early research shows that a selected intravaginal progesterone cream may help reverse the abnormal thickening of the endometrium and reduce vaginal bleeding in premenopausal women with non-cancerous endometrial hyperplasia.
• Breast pain (mastalgia). Some research advises that applying progesterone (Crinone) into the vagina seems to scale back breast pain and tenderness in women with non-cancerous breast disease.
• Symptoms of the menopause. Some research suggests that applying a selected progesterone cream (Progest) to the skin reduces symptoms like hot flashes in menopausal women.
• Preterm birth. Most research suggests that applying progesterone gel or inserts into the vagina, alone or alongside therapy to delay labor (tocolytic therapy), reduces the danger of premature birth in some women at high risk of premature birth. However, other research suggests that applying progesterone gel into the vagina doesn't decrease premature birth rates in women with a history of premature birth. The effect of progesterone on premature birth in women with twin pregnancies isn't clear.

Possibly Ineffective for

• A skin accustom that mainly affects the genital and anal areas (lichen sclerosis). Applying progesterone into the vagina doesn't seem to enhance symptoms of vulval lichen sclerosus. In fact, progesterone seems to be less compelling than clobetasol (Temovate) for treating this condition.
• Miscarriage. Most research shows that applying progesterone into the vagina doesn't reduce the danger of getting a miscarriage in women who are bleeding during pregnancy or with a history of miscarriages within the past. Also, injecting progesterone and another steroid into the muscle after undergoing a test wont to diagnose birth defects (called an amniocentesis) doesn't seem to scale back the danger of miscarriage or preterm delivery. However, some early research suggests that taking progesterone orally might reduce the danger of miscarriage in women who are bleeding during pregnancy.
• Premenstrual syndrome (PMS). Although some clinical research suggests that applying progesterone into the vagina or the rectum before menstruation reduces symptoms of PMS, most evidence shows that giving progesterone orally or rectally doesn't reduce PMS symptoms.

Insufficient Evidence for

• Withdrawal from drugs called benzodiazepines. Some research suggests that taking micronized progesterone orally might not be effective for relieving symptoms of withdrawal and for helping people to abstain from taking diazepam.
• Heart disease. Early research suggests that applying progesterone into the vagina may increase exercise endurance compared to taking an identical steroidal drug (medroxyprogesterone) orally in women with heart conditions or women that previously experienced a attack.
• Cocaine use disorder. Early research suggests that taking progesterone orally doesn't decrease the danger of cocaine use in methadone-stabilized male cocaine users.
• Weak and brittle bones (osteoporosis). Some research suggests that applying progesterone to the skin isn't effective for increasing bone mineral density in postmenopausal women. Other research shows that applying progesterone to the skin for two years could also be as effective for preventing bone loss as drinking isoflavone-containing soy milk. However, the mixture of soy milk plus progesterone seems to result in greater bone loss than either single treatment alone.
• Depression after childbirth (postpartum). Early research suggests that applying progesterone into the rectum doesn't reduce symptoms of postpartum depression.
• A pregnancy complication marked by high vital signs and protein within the urine (pre-eclampsia). Early research suggests that single injections of progesterone reduce vital sign, swelling, and other symptoms in women with pre-eclampsia.
• Injury to the brain, spine, or nerves (neurological trauma). Some research advises that injecting progesterone soon after brain injury prevents death and disability. However, other research suggests that progesterone doesn't decrease the frequency of death or disability.
• Bloating.
• Decreased drive.
• Fatigue.
• "Foggy thinking".
• Headaches.
• Increased blood coagulation.
• Irritability.
• Low blood glucose (hypoglycemia).
• Memory loss.
• Thyroid problems.
• Treating or preventing allergies suffering from hormones.
• Uterine cancer.
• Uterine fibroids.
• Water retention.
• Weight gain.
• Other conditions.

More evidence is the lack to rate the effectiveness of progesterone for these uses.

Side Effects

When taken by mouth: The progesterone prescription products that are approved by the Food and Drug Administration (FDA) are LIKELY SAFE for many people when employed by mouth with the recommendation and care of a healthcare professional.

When applied to the skin: The progesterone prescription products that are approved by the Food and Drug Administration (FDA) are LIKELY SAFE for many people when applied to the skin with the recommendation and care of a healthcare professional.

When given as a shot: The progesterone prescription products that are approved by the Food and Drug Administration (FDA) are LIKELY SAFE for many people when injected into the muscle with the recommendation and care of a healthcare professional.

When applied into the vagina: The progesterone prescription products that are approved by the Food and Drug Administration (FDA) are LIKELY SAFE for many people when applied into the vagina with the recommendation and care of a healthcare professional.

Special Precautions and Warnings

Pregnancy and breastfeeding: Intravaginal progesterone gel is probably going SAFE when used as a part of infertility treatment or to stop premature birth. However, progesterone is probably going UNSAFE when used during pregnancy for another purpose.

There isn't enough reliable information to understand if progesterone is safe to use when breastfeeding. stay on the safe side and avoid use.

Arterial disease: Don't use progesterone if you've got the arterial disease.

Breast cancer: Avoid use unless you're directed to try to do so by your healthcare provider.

Depression: Get your healthcare provider's advice first before using progesterone if you've got major depression now or a history of major depression.

Liver disease: Progesterone might make the disease worse. Don't use it.

Porphyria: Progesterone might cause an attack of porphyria. Don't use it.

Vaginal bleeding: If you've got undiagnosed vaginal bleeding, don't use progesterone.

Interactions?

Moderate Interaction
Be cautious with this mix

Estrogens interact with PROGESTERONE
Progesterone and estrogen are both hormones. they're often taken together. Progesterone can decrease the number of side effects of estrogen. But progesterone may additionally decrease the beneficial effects of estrogen. Taking progesterone alongside estrogen might cause breast tenderness.

Some estrogen pills include conjugated equine estrogens (Premarin), Ethinyl estradiol, estradiol, et al..