Dermi 5 Cream (Clobetasol + Gentamicin + Clotrimazole + Clioquinol (Iodochlorhydroxyquin) + Tolnaftate )
​Dermi 5 Cream is a potent topical medication designed to treat a variety of skin infections caused by bacteria and fungi. Its unique combination of active ingredients offers anti-inflammatory, antibacterial, and antifungal properties, making it effective for conditions like eczema, psoriasis, dermatitis, and ringworm.
Product Overview
Dermi 5 Cream is a comprehensive "5-in-1" dermatological solution designed to treat complex skin disorders involving inflammation complicated by bacterial or fungal infections. This multi-action formula combines a super-potent corticosteroid, a broad-spectrum antibiotic, and three distinct antifungal agents to provide rapid relief from severe itching, redness, and swelling. By addressing multiple pathogenic sources simultaneously, Dermi 5 Cream is highly effective for mixed skin infections where the exact cause—whether fungal, bacterial, or inflammatory—may be overlapping. Its versatile base ensures effective delivery of all active ingredients into the skin to promote rapid healing and clear stubborn lesions.
Product Composition
- Clobetasol Propionate: An ultra-high potency corticosteroid that rapidly suppresses severe inflammation and itching.
- Gentamicin Sulphate: A broad-spectrum aminoglycoside antibiotic that eliminates primary and secondary bacterial infections.
- Clotrimazole: A versatile antifungal agent effective against a wide range of yeasts and dermatophytes.
- Clioquinol (Iodochlorhydroxyquin): An antimicrobial agent with both antibacterial and antifungal properties to broaden the spectrum of action.
- Tolnaftate: A specialized antifungal used specifically to target and eradicate the fungi responsible for athlete's foot and ringworm.
- Cream Base: Formulated for smooth application and optimal absorption of the five active ingredients.
Product Specification
| Feature | Details |
| Product Category | Multi-Combination Topical Cream |
| Therapy Type | Antibacterial, Antifungal, and Anti-inflammatory |
| Potency Class | Ultra-High Potency (due to Clobetasol) |
| Formulation | Non-greasy Topical Cream |
| Primary Indication | Mixed or Resistant Skin Infections |
| Target Microorganisms | Bacteria, Fungi, and Yeasts |
Mechanism of Action
- Immediate Anti-Inflammatory Response: Clobetasol binds to glucocorticoid receptors to inhibit the release of inflammatory mediators like prostaglandins and leukotrienes.
- Bacterial Protein Inhibition: Gentamicin disrupts bacterial protein synthesis by binding to the 30S ribosomal subunit, leading to bacterial cell death.
- Fungal Cell Membrane Disruption: Clotrimazole inhibits ergosterol synthesis, creating structural damage in the fungal cell wall.
- Multi-Pathogen Neutralization: Clioquinol interferes with the DNA replication of various microbes, providing an extra layer of defense against mixed infections.
- Fungal Growth Inhibition: Tolnaftate distorts the hyphae and stunts the mycelial growth of susceptible fungi, preventing the spread of the infection.
- Synergistic Relief: The combined action quickly reduces the "itch-scratch" cycle while sterilizing the affected area from pathogens.
Key Benefits
- Comprehensive Infection Control: Treats mixed skin conditions where bacteria and fungi are present at the same time.
- Rapid Symptom Relief: Provides almost immediate reduction in intense itching, burning, and painful swelling.
- Broad-Spectrum Efficacy: Eliminates a wide variety of pathogens, making it useful when the specific cause of infection is unknown.
- High Success Rate: Effective against resistant skin conditions that have failed to respond to single-ingredient creams.
- Versatile Application: Suitable for a range of dermatological issues from infected eczema to stubborn ringworm.
Precautions
General Precautions
| Condition | Guidance |
|---|---|
| Strong combination cream | Use only under medical supervision due to high potency ingredients |
| Skin infections type | Do not use for viral skin infections like herpes or chickenpox |
| Long-term use | Avoid prolonged use due to risk of steroid side effects and resistance |
| Sensitive areas | Use cautiously on face, groin, and underarms |
| Children | Not recommended unless specifically prescribed by a doctor |
| Pregnancy and breastfeeding | Consult doctor before use |
Application Precautions
- Apply a thin layer only on affected areas
- Wash hands before and after application
- Do not cover with airtight bandages unless advised
- Avoid use on large areas of skin
- Use exactly as prescribed, do not overuse
Infection and Resistance Precautions
- Do not use without confirmed diagnosis of mixed infection
- Avoid self-medication as it may worsen condition
- Do not stop treatment early even if symptoms improve
- Maintain proper hygiene to prevent reinfection
Skin Safety Precautions
- May cause skin thinning with prolonged use due to steroid component
- Stop use if severe irritation or allergic reaction occurs
- Avoid contact with eyes, nose, and mouth
- Do not use on broken or severely damaged skin without advice
When to Consult a Doctor
- If no improvement after a few days of use
- If infection spreads or worsens
- If severe redness, burning, or swelling occurs
- If signs of allergic reaction appear
- If repeated infections occur frequently
Usage
Dosage
Dermi 5 Cream should be applied in a thin layer to the affected skin areas two to three times daily, or as specifically directed by a medical professional. Because it contains Clobetasol, a super-potent steroid, it is intended for short-term use only. Treatment should generally not exceed two consecutive weeks. If the infection does not show improvement within 7 days, consult a physician for reassessment.
Administration
| Step | Action |
| Preparation | Clean the infected area with mild soap and water and dry thoroughly |
| Hygiene | Wash your hands before and after applying the cream |
| Application | Apply a small amount of cream and spread it evenly over the lesion |
| Absorption | Gently massage the medication into the skin until it is fully absorbed |
| Restriction | Do not cover the treated area with bandages or dressings unless advised |
| Safety | Avoid applying on the face, underarms, or groin area |
Uses
Mixed Skin Infections: Effectively treats conditions where bacterial and fungal infections occur simultaneously.
Infected Dermatitis: Relieves inflammation in eczema or atopic dermatitis that has become infected due to scratching.
Stubborn Ringworm: Clears persistent fungal infections (Tinea Corporis) that involve significant redness and swelling.
Infected Psoriasis: Manages plaque psoriasis flare-ups that are complicated by secondary microbial colonization.
Severe Athlete’s Foot: Provides a dual-action approach to treat fungal infections of the feet with associated bacterial involvement.
Resistant Skin Rashes: Targets intense, itchy rashes that have not responded to standard antifungal or steroid treatments.
Side Effects
Common Side Effects
- Mild burning or stinging at the application site
- Itching or irritation of the skin
- Dryness or peeling
- Redness around the treated area
- Mild discomfort during initial days of use
Less Common Side Effects
- Skin thinning with prolonged use (due to steroid component)
- Increased sensitivity of the skin
- Acne-like eruptions or folliculitis
- Skin discoloration or lightening
- Delayed wound healing
Serious Side Effects
| Side Effect | Description |
|---|---|
| Severe skin thinning | Fragile skin, easy bruising, visible veins with long-term use |
| Allergic reaction | Rash, swelling, hives, or intense itching requiring discontinuation |
| Worsening infection | Spread or persistence of bacterial or fungal infection despite treatment |
| Steroid-related systemic effects | Rare hormonal imbalance with excessive or prolonged use |
| Severe irritation | Persistent burning, redness, or pain at application site |
Skin Safety Considerations
- Risk of irritation increases with overuse or prolonged application
- Sensitive skin may react more strongly to combination ingredients
- Broken or inflamed skin may absorb more medication than intended
When to Stop Use and Consult a Doctor
- If severe irritation, burning, or swelling occurs
- If allergic symptoms such as rash or hives appear
- If infection worsens or does not improve
- If skin becomes unusually thin or discolored
- If any unusual or persistent side effects develop
FAQs
Q: What is Dermi 5 Cream?
A: Dermi 5 Cream is a broad-spectrum topical combination cream containing five active ingredients — Clobetasol Propionate 0.05%, Gentamicin 0.1%, Clotrimazole 1%, Clioquinol (Iodochlorhydroxyquin) 1%, and Tolnaftate 1%. It provides antibacterial, antifungal, and anti-inflammatory action to treat complex skin infections.
Q: What is Dermi 5 Cream used for?
A: It is used to treat complex skin infections involving both bacteria and fungi including infected eczema, ringworm, dermatitis, allergic skin reactions, rashes, and psoriasis. It relieves symptoms such as redness, itching, swelling, and inflammation while preventing the infection from spreading further.
Q: How does Dermi 5 Cream work?
A: Each ingredient targets the infection differently:
- Clobetasol Propionate – a potent corticosteroid that blocks chemical messengers causing redness, swelling, and itching
- Gentamicin – an aminoglycoside antibiotic that kills bacteria by inhibiting protein synthesis
- Clotrimazole – an antifungal that disrupts fungal cell membranes, leading to their death
- Tolnaftate – an antifungal that interferes with fungal cell wall formation to prevent growth
- Clioquinol – an antibiotic with additional antifungal properties that prevents the growth and multiplication of both bacteria and fungi
Q: How should I apply Dermi 5 Cream?
A: Wash the affected area with a mild cleanser and pat dry. Apply a thin layer of the cream to the clean, dry, affected skin as prescribed by your doctor. Avoid contact with eyes, nose, and mouth. Wash your hands after application unless the hands are the area being treated.
Q: How long does it take to see results?
A: Improvement in symptoms such as itching, redness, and swelling is usually noticed within a few days of regular use. Always complete the full course of treatment as prescribed by your doctor even if symptoms improve earlier.
Q: Can Dermi 5 Cream be used on the face?
A: Use on the face only if specifically prescribed by your doctor. Prolonged use on facial skin may cause skin thinning and other local side effects due to the presence of Clobetasol, a potent corticosteroid.
Q: Is Dermi 5 Cream safe for children?
A: Dermi 5 Cream is not recommended for children below 12 years of age. Use in children should only be under strict medical supervision with the shortest effective duration and lowest possible dose.
Q: Can it be used during pregnancy or breastfeeding?
A: Caution is advised during pregnancy. Consult your doctor before using Dermi 5 Cream during pregnancy or breastfeeding. It is considered probably safe during breastfeeding, but should only be used on your doctor's recommendation.
Q: What are the possible side effects?
A: Dermi 5 Cream is generally well-tolerated when used as directed. Some may experience:
- Mild burning, stinging, or irritation at the application site
- Skin dryness or peeling
- Redness or itching
- Skin thinning with prolonged use
- Acne-like eruptions
Consult your doctor if any side effect persists or worsens.
Q: Can Dermi 5 Cream be used on broken or infected skin?
A: Do not apply Dermi 5 Cream to broken or severely damaged skin without medical advice. Avoid applying to open wounds, sunburned, or severely irritated skin unless specifically directed by your doctor.
Q: Is long-term use of Dermi 5 Cream safe?
A: Long-term or excessive use is not recommended. Prolonged use may lead to skin thinning, stretch marks, and over-absorption of the medicine into the body. Always follow your doctor's recommended duration of treatment.
Q: Can it be applied to large areas of skin?
A: Avoid applying Dermi 5 Cream to large areas of skin without medical supervision. Excessive application may lead to increased systemic absorption and the risk of serious side effects.
Q: Can Dermi 5 Cream be used under bandages or dressings?
A: Do not cover the treated area with airtight or occlusive dressings unless specifically instructed by your doctor, as this may increase absorption and the risk of side effects.
Q: Can it be used with other skincare products?
A: Avoid applying other creams, lotions, or topical medications to the same area simultaneously unless advised by your doctor. Inform your doctor about all skincare products you are currently using.
Interactions
Topical Medicine Interactions
| Product Type | Interaction Details |
|---|---|
| Other corticosteroids | May increase risk of skin thinning and systemic steroid absorption |
| Other antifungal creams | Redundant use may not improve results and can increase irritation |
| Other antibiotic creams | Can increase risk of skin irritation and antibiotic resistance |
| Retinoids or acne treatments | May cause excessive dryness, peeling, and irritation |
| Benzoyl peroxide | Can increase skin irritation and reduce tolerance of combination therapy |
Skincare and Cosmetic Interactions
- Avoid alcohol-based lotions or toners on the same area
- Do not apply strong exfoliants or scrubs during treatment
- Heavy cosmetics may trap infection and delay healing
- Moisturizers should be used only if advised and applied separately
Medication Interactions
- No major systemic drug interactions expected with topical use
- Inform doctor if using oral steroids, antifungals, or antibiotics
- Combined use with other prescription dermatology treatments should be medically supervised
Skin Condition Interactions
- May worsen untreated viral infections like herpes or chickenpox
- Can mask symptoms of underlying infections due to steroid component
- Overuse may delay proper diagnosis and treatment of resistant infections
Usage Related Interactions
- Occlusive dressings can increase absorption and side effects risk
- Applying on large areas may increase systemic exposure
- Poor hygiene can reduce effectiveness and lead to reinfection
When to Seek Advice
- If using multiple medicated skin treatments simultaneously
- If irritation, burning, or worsening infection occurs
- If no improvement is seen within the prescribed duration
- If unsure about combining with other creams or medications
| Manufacturer | : | A. Menarini India Pvt Ltdine HCL) |
| Trade Name | : | |
| Generic Search | : | Clobetasol + Gentamicin + Tolnaftate + Iodochlorhydroxyquinoline + Clotrimazole |
| Strength | : | 15g |
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