Cyclovol Injection (Dicyclomine) | Used for Abdominal Pain and Stomach Cramp Relief
Cyclovol Injection (Dicyclomine) is an anticholinergic (antispasmodic) agent administered by intramuscular injection, used to relieve smooth muscle spasms of the gastrointestinal tract. It works by blocking muscarinic acetylcholine receptors in the smooth muscle of the gut, reducing involuntary muscle contractions and relieving painful spasms.
Product Overview
Cyclovol Injection is a highly effective, fast-acting antispasmodic and anticholinergic medication formulated with Dicyclomine Hydrochloride to relieve severe gastrointestinal smooth muscle spasms. By targeting and relaxing the hyperactive smooth muscles within the stomach and intestines, this injectable solution rapidly alleviates sharp abdominal pain, cramping, and bloating. It is widely utilized in clinical settings for the short-term management of acute exacerbations of functional bowel disorders, particularly when oral administration is impractical or unavailable.
Product Composition
Active Therapeutic Agent: Dicyclomine Hydrochloride (standardized at 10 mg per milliliter, typically provided in 2 mL ampoules or multidose vials)
Osmotic Tonicity Regulator: Sodium Chloride
pH Stabilizers: Hydrochloric Acid and/or Sodium Hydroxide
Solvent Vehicle Base: Sterile Water for Injection
Product Specification
| Feature | Detail |
| Dosage Form | Clear, Colorless Sterile Solution for Injection |
| Therapeutic Class | Antispasmodic / Anticholinergic (Antimuscarinic) Agent |
| Administration Route | Intramuscular Injection Only |
| Storage Parameters | Store below 25 Degrees Celsius protect from freezing and direct light |
Mechanism of Action
- Muscarinic Receptor Antagonism: Competitively blocks post-ganglionic muscarinic acetylcholine receptors on gastrointestinal smooth muscle cells, preventing parasympathetic activation.
- Direct Myotropic Relaxation: Exerts a direct, local spasmolytic effect on intestinal smooth muscle fibers, independent of the nervous system, by modifying calcium ion influx.
- Peristaltic Wave Slowing: Reduces the frequency, amplitude, and velocity of hypermotile contractions throughout the digestive tract, normalizing structural movement.
- Secretory Inhibition: Moderates baseline gastric, bronchial, and salivary secretions by dampening regional cholinergic neurotransmission pathways.
Key Benefits
- Rapid Acute Cramping Relief: Delivers prompt physical turnaround during intense, agonizing visceral spasms by relaxing hyperactive abdominal structures within minutes.
- Targeted Gastrointestinal Action: Demonstrates high specificity for the smooth musculature of the digestive tract, resolving bloating, wind, and secondary pressure discomfort.
- Practical Short-Term Alternative: Provides a reliable clinical alternative for individuals experiencing acute distress who cannot tolerate oral tablets due to nausea, vomiting, or fasting requirements.
- Non-Habit-Forming Stabilization: Achieves complete physical relief without carrying a risk of chemical dependency or habit-forming biological adaptations.
Precautions
Important Safety Information Before Using Cyclovol Injection
Cyclovol Injection (Dicyclomine) should be used carefully to help relieve abdominal pain and intestinal spasms while reducing the risk of unwanted effects.
| Precaution | Details |
|---|---|
| Medical Supervision | Should be given under proper medical guidance |
| Dosage Control | Use only the recommended dose |
| Driving Safety | May cause dizziness or drowsiness |
| Alcohol Avoidance | Alcohol may increase side effects |
| Medical History | Inform about heart, liver, or kidney issues |
| Eye Conditions | Use carefully in glaucoma patients |
| Urination Issues | Caution in urinary retention cases |
| Monitoring | Observe for unusual symptoms after injection |
Use Carefully In
- Elderly patients
- People with heart disease
- Individuals with glaucoma
- Patients with urinary problems
Storage Instructions
- Store in a cool and dry place
- Protect from direct sunlight
- Do not freeze
- Keep out of reach of children
Helpful Usage Tips
- Use only when prescribed
- Monitor relief from abdominal pain
- Maintain hydration during treatment
- Avoid self administration without guidance
Usage
Administration
Strict Intramuscular Route: Administer exclusively via deep intramuscular injection into a large muscle mass, such as the gluteal muscle.
Prohibit Intravenous Use: Never inject this solution intravenously or subcutaneously, as direct entry into blood vessels or shallow tissues can lead to severe local irritation and tissue damage.
Aseptic Handling Protocol: Clean the injection site thoroughly with an antiseptic swab before administration. Always utilize a sterile needle and syringe for every application to prevent cross-contamination.
Check for Discoloration: Inspect the ampoule visually before drawing up the fluid; the solution must be clear and completely colorless. Discard immediately if any cloudiness, particulate matter, or discoloration is detected.
Aspiration Verification: Always aspirate by pulling back slightly on the syringe plunger before injecting to confirm that a blood vessel has not been accidentally entered.
Dosage
| Patient Profile | Administration Plan |
| Standard Adult Routine | Typically administered as 10 mg intramuscularly, which can be repeated up to four times daily based on clinical response. |
| Duration Limit | Confined strictly to short-term emergency stabilization, usually spanning one to two days before transitioning to oral therapies. |
| Elderly Caution Plan | Administered at the lower end of the dosing spectrum due to an increased baseline sensitivity to anticholinergic side effects. |
Uses
Acute Smooth Muscle Relaxation
Severe Gastrointestinal Spasms: Rapidly relaxes hyperactive smooth muscles in the stomach and intestines, providing quick relief from debilitating abdominal cramps.
Irritable Bowel Syndrome Exacerbations: Manages sudden, agonizing flare-ups of functional bowel disorders when intense pain or vomiting prevents the use of oral medications.
Visceral Colic Control
Functional GI Pain Management: Alleviates sharp pain, bloating, and intense visceral pressure caused by functional smooth muscle hypermotility throughout the digestive tract.
Post-Operative Gastrointestinal Distress: Controls temporary, hyperactive bowel contractions in specialized clinical environments following specific diagnostic procedures.
Side Effects
Possible Side Effects of Cyclovol Injection
Cyclovol Injection (Dicyclomine) may cause certain side effects due to its action on smooth muscles and the nervous system. Most effects are mild and temporary.
| Side Effect | Details |
|---|---|
| Dry Mouth | Reduced saliva production |
| Drowsiness | Feeling sleepy or tired |
| Dizziness | Lightheadedness or unsteady feeling |
| Blurred Vision | Temporary vision disturbance |
| Nausea | Mild stomach discomfort |
| Constipation | Reduced bowel movements |
| Increased Heart Rate | Faster heartbeat in some cases |
| Weakness | General tiredness |
Less Common Side Effects
- Difficulty urinating
- Confusion (especially in elderly)
- Skin rash or allergic reaction
- Abdominal bloating
How to Reduce Side Effects
- Take only as prescribed
- Avoid alcohol during treatment
- Stay hydrated
- Avoid driving if feeling drowsy
When to Seek Medical Attention
- Severe confusion or dizziness
- Difficulty urinating
- Fast or irregular heartbeat
- Severe allergic reactions or swelling
FAQs
Q: What is Cyclovol Injection used for?
A: It is used to relieve smooth muscle spasms of the gastrointestinal tract, commonly treating conditions such as irritable bowel syndrome (IBS), biliary colic, renal colic, and other functional gastrointestinal disorders characterized by abdominal cramping and pain.
Q: How does Dicyclomine work?
A: It works by blocking muscarinic acetylcholine receptors in the smooth muscle of the gut, reducing involuntary muscle contractions and relieving painful spasms, thereby providing rapid relief from abdominal pain and discomfort.
Q: How is Cyclovol Injection administered?
A: It is administered by a healthcare professional via intramuscular (IM) injection. The dose and frequency are determined by the doctor based on the severity of the condition being treated.
Q: Why is the injection form preferred over oral forms in some cases?
A: The injection form offers a faster onset of action compared to oral forms, making it particularly useful in acute or severe episodes of abdominal pain and spasm where rapid relief is needed.
Q: How quickly does Cyclovol Injection work?
A: Being administered by injection, it typically provides rapid relief from abdominal spasms and pain within a short time after administration, making it effective for acute episodes.
Q: What are the common side effects?
A: Common side effects include dry mouth, blurred vision, dizziness, urinary retention, constipation, increased heart rate, and drowsiness. These are related to its anticholinergic properties and are generally manageable.
Q: Can Cyclovol Injection be used in children?
A: It is contraindicated in infants under 6 months of age due to the risk of serious adverse effects. Use in older children should be under strict medical supervision with dosage carefully adjusted by the doctor.
Q: Can it be used in elderly patients?
A: Caution is advised in elderly patients as they are more sensitive to anticholinergic side effects such as urinary retention, constipation, confusion, and increased heart rate. A lower dose and close monitoring are recommended.
Q: Are there any conditions where Cyclovol Injection should not be used?
A: It should not be used in patients with glaucoma, urinary retention, myasthenia gravis, severe ulcerative colitis, or obstructive gastrointestinal disease. Always inform your doctor of your complete medical history before use.
Interactions
Possible Interactions with Cyclovol Injection
Cyclovol Injection (Dicyclomine) may interact with certain medicines and substances. These interactions can increase side effects like drowsiness, dry mouth, or reduced intestinal motility.
| Product Type | Possible Effect |
|---|---|
| Antacids | May reduce effectiveness |
| Antidepressants | Increased side effects like dry mouth or dizziness |
| Antihistamines | Increased drowsiness and sedation |
| Pain Killers | May increase dizziness or sedation |
| Sleeping Tablets | Stronger sedative effects |
| Antipsychotic Medicines | Increased risk of side effects |
| Alcohol | Can increase drowsiness and confusion |
| Other Antispasmodics | May increase anticholinergic effects |
Use Carefully With
- Multiple CNS acting medicines
- Long term pain management drugs
- Sedative or sleep inducing medicines
- Gastrointestinal motility affecting drugs
Helpful Monitoring Tips
- Inform about all ongoing medicines
- Avoid alcohol during treatment
- Monitor for excessive dryness or dizziness
- Follow medical guidance strictly
When to Seek Medical Attention
- Severe dizziness or confusion
- Difficulty urinating
- Rapid heartbeat
- Allergic reactions or swelling
| Manufacturer | : | Universal Micro Sciences |
| Trade Name | : | Bentyl |
| Generic Search | : | Dicyclomine |
| Strength | : | 10mg |
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