Rabiace LS Tablet( Rabeprazole and Levosulpiride)
Rabiace LS Tablet contains Rabeprazole, a proton pump inhibitor that irreversibly inhibits the H⁺/K⁺ ATPase enzyme in gastric parietal cells, leading to profound and sustained reduction of gastric acid secretion. Levosulpiride, a selective dopamine D2 receptor antagonist, enhances gastrointestinal motility by increasing lower esophageal sphincter tone and promoting gastric emptying.
Introduction of Rabiace LS Tablet( Rabeprazole and Levosulpiride)
Rabiace LS Tablet is a fixed-dose combination therapy used in the management of acid-related gastrointestinal disorders associated with impaired motility. It combines the acid-suppressive action of Rabeprazole with the prokinetic effect of Levosulpiride, providing comprehensive symptom control in conditions like Gastroesophageal reflux disease (GERD) and functional dyspepsia.
Precautions of Rabiace LS Tablet
- Rule out gastric malignancy before initiation
- Use cautiously in patients with renal or hepatic impairment
- Monitor for extrapyramidal symptoms with levosulpiride
- Risk of hyperprolactinemia with prolonged use
- Long-term use of PPIs may cause vitamin B12 deficiency and hypomagnesemia
- Caution in elderly patients
- Use in pregnancy and lactation only if clearly indicated
Usage of Rabiace LS Tablet
- Administer once daily, preferably before meals
- Swallow whole; do not crush or chew
- Dosage and duration should be individualized based on clinical condition
- Ensure patient compliance for optimal therapeutic outcomes
- Suitable for short-term and maintenance therapy under medical supervision
Side Effects of Rabiace LS Tablet
- Common: headache, nausea, diarrhea, abdominal discomfort, dizziness
- CNS-related: drowsiness, restlessness (due to levosulpiride)
- Endocrine: increased prolactin levels, galactorrhea (rare)
- Long-term: vitamin B12 deficiency, hypomagnesemia
- Rare: extrapyramidal symptoms, allergic reactions
FAQs of Rabiace LS Tablet
1. What is Rabiace LS Tablet?
Rabiace LS Tablet is a combination of Rabeprazole and Levosulpiride designed to manage acid-related disorders with associated gastrointestinal motility issues.
2. What are the therapeutic indications?
It is indicated for Gastroesophageal reflux disease (GERD), functional dyspepsia, gastritis, and delayed gastric emptying.
3. How does Rabiace LS Tablet work?
Rabeprazole suppresses gastric acid secretion by inhibiting the proton pump, while levosulpiride enhances gastrointestinal motility by blocking dopamine D2 receptors.
4. What are the key clinical advantages of this combination?
It provides dual benefits—effective acid suppression and improved gastric motility—leading to faster and sustained symptom relief.
5. What is the recommended dosage regimen?
Typically administered once daily before meals or as directed by the physician.
6. What are the common side effects?
Headache, nausea, diarrhea, abdominal discomfort, dizziness, and flatulence.
7. What are the serious adverse effects?
Rarely, extrapyramidal symptoms, hyperprolactinemia, menstrual irregularities, and allergic reactions may occur.
8. What precautions should be taken?
Use cautiously in patients with renal or hepatic impairment, neurological disorders, or history of prolactin-related conditions.
Interactions of Rabiace LS Tablet
- Rabeprazole may reduce absorption of drugs requiring acidic pH (e.g., ketoconazole, itraconazole)
- Possible interaction with clopidogrel (reduced antiplatelet activity)
- Levosulpiride may interact with antipsychotics and CNS depressants
- Concomitant use with levodopa may reduce its efficacy
- Caution with digoxin and methotrexate
- Inform physician about all concomitant medications
| Manufacturer | : | Healing Pharma |
| Trade Name | : | |
| Generic Search | : | Rabeprazole and Levosulpiride |
| Strength | : | 20mg,75mg |
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