Isokin 300mg (Isoniazid 300mg / Pyridoxine 10mg) Used in The Treatment of Tuberculosis (TB)

Precautions of Isokin 300mg 

• Do not consume alcohol during treatment — risk of liver damage
• Not recommended for patients with severe liver disease
• Use cautiously in those with a history of seizures or psychiatric disorders
• Regular liver function monitoring is advised during long-term use
• Use in pregnancy or breastfeeding only if prescribed

Uses of Isokin 300mg 

• Treatment of active tuberculosis
• Prophylaxis (prevention) in high-risk individuals (e.g., those in close contact with TB patients or with HIV)
• Part of combination TB therapy with other anti-TB drugs

Side Effects of Isokin 300mg 

Common Side Effects:

• Nausea or vomiting
• Fatigue
• Mild skin rash

Serious Side Effects (seek immediate medical attention):

• Peripheral neuropathy (numbness, tingling)
• Liver toxicity (yellowing of skin/eyes, dark urine)
• Mental/mood changes (confusion, seizures)
• Severe allergic reactions

FAQs of Isokin 300mg 

Q1. Can Isokin be taken alone for TB treatment?
A: No, it's usually part of a combination therapy unless used for TB prevention.

Q2. Why is Vitamin B6 included?
A: To prevent nerve damage (peripheral neuropathy), a side effect of isoniazid.

Q3. Can I drink alcohol while taking Isokin?
A: Avoid alcohol—it increases the risk of liver damage.

Q4. How long should I take Isokin?
A: As prescribed—usually 6 to 9 months for prevention, longer for treatment.

Q5. Is it safe during pregnancy?
A: It may be used under strict medical supervision.

Interactions of Isokin 300mg 

• Alcohol: Increases risk of liver damage
• Phenytoin: Isoniazid may increase its levels
• Carbamazepine, Valproate: May require dose adjustment
• Antacids (containing aluminum): Can reduce Isoniazid absorption – take at least 1 hour apart