Zonisep Capsule (Zonisamide)

What is Zonisamide Capsule?

Zonisamide Capsule is a sulfa drug that also has anti-convulsant properties. It is prescribed in combination with other anticonvulsant medications for the treatment of partial seizures in adults with epilepsy. Zonisamide is sold under various trade names, some of which are Zonegran and Zonisep. This medication may also be given for conditions not described here. Zonisep Capsule (Zonisamide) is a medication that is primarily used for the treatment of epilepsy. Here are some of the benefits associated with Zonisamide:

Zonisamide for epilepsy Treatment:  Zonisep Capsule contains the active ingredient Zonisamide, which is an anticonvulsant medication. It helps control and prevent seizures in individuals with epilepsy. By stabilizing electrical activity in the brain, Zonisamide reduces the occurrence and severity of seizures, allowing individuals to lead a more normal and active life.

Adjunctive Therapy: Zonisamide can be used as an adjunctive therapy in the treatment of partial seizures in adults with epilepsy. When used alongside other antiepileptic drugs, Zonisamide can provide additional seizure control and improve overall seizure management.

Zonisamide for weight loss: Zonisamide has also been associated with weight loss in some individuals. While the exact mechanism is not fully understood, it is believed that Zonisamide affects certain brain chemicals and pathways involved in appetite regulation. As a result, some individuals may experience a decrease in appetite and subsequent weight loss while taking Zonisamide.

Combination with Topiramate:  Zonisamide and topiramate are both anticonvulsant medications commonly used for the treatment of epilepsy. In some cases, they may be prescribed together to enhance the effectiveness of seizure control. This combination therapy can provide additive benefits and may be particularly useful in individuals who do not respond well to either medication alone.

It is important to note that the use of Zonisep Capsule should always be under the guidance and prescription of a qualified healthcare professional. They will evaluate your specific condition, consider potential side effects, and determine the appropriate dosage to ensure safe and effective treatment.

Zonisamide Uses

Zonisamide is used to treat partial seizures (fits due to the involvement of only one side of the brain).

How it works

Zonisamide is an anticonvulsant that belongs to a group of medicines called sulfonamides. It works by decreasing abnormal electrical activity in the brain.

Precautions of  Zonisep Capsule (Zonisamide) 

Do not take Zonisamide anti-convulsant medication (Zonegran, Zonisep) if you are allergic to it, or to other sulfa drugs like sulfisoxazole, sulfamethoxazole, or sulfamethoxazole-trimethoprim. An allergic reaction due to the sulfa drug can be dangerous and fatal. This medication must not be taken by children younger than 16 years old without thorough medical screening.

Zonisamide usage may lead to suicidal thoughts. This side effect may require you to undergo regular follow-up checks by your doctor. You must notify your doctor about any new or deteriorating symptoms like mood or behavior changes, depression, anxiety, suicidal or self-hurting thoughts, increased agitation, hostility, restlessness, and hyperactivity (mentally or physically). Your family member and caregivers if any must be on alert for these conditions.

You must continue taking Zonisamide even after you stop getting seizures and feel absolutely fine. Stopping the medication abruptly and without a doctor's advice may result in increased seizures, deteriorating your condition. Remember to follow your doctor's instructions. This medication may impact your thinking capability and reflexes. So take extra care while indulging in activities that require a high degree of mental awareness and thinking such as driving

Zonisamide is an FDA pregnancy category C drug. This medication is reported to have caused birth defects and infant death in animal studies. It is, however, not known whether the same would be true in humans. This medication can cause metabolic acidosis which can harm an unborn baby if taken during pregnancy. This medication can pass into breast milk and harm a nursing baby. You must consult your doctor prior to taking Zonisamide if you are pregnant, planning to get pregnant, or breastfeeding. Proper contraception use is recommended while you are taking Zonisamide medication.

Before taking Zonisamide

Remember to discuss all the points mentioned above with your doctor and take all the necessary precautions that are also mentioned above before taking Zonisamide. To ensure that Zonisamide anti-convulsant medication (Zonegran, Zonisep) is safe for you, notify your doctor in advance before he or she prescribes you this medication, about any of your pre-existing conditions like kidney or liver disease, stomach flu, or illness resulting in diarrhea, a growth disorder, a bone disorder that causes soft or weak bones or low bone mineral density, asthma or other breathing troubles, episodes of suicidal thoughts or actions, or if you take high protein, low card diet.

How should I take Zonisamide?

Take Zonisamide anti-convulsant medication (Zonegran, Zonisep) strictly according to your doctor's direction or according to the instructions on the medication label. Do not alter the dosage unless your doctor advises you to do so. Also, do not take this medication after the prescribed period is over. All medications come with a patient leaflet. Refer to the instructions in them for detailed information on that particular medication. Take Zonisamide with a glass of water. It can be taken with or without food. You must drink enough water (about 6 to 8 glasses every day) while you take this medication to prevent any chance of kidney stones. Avoid crushing, breaking, or chewing a Zonisamide tablet. Instead, swallow it whole. Always store Zonisamide in a cool and dry place, away from heat and moisture. Ensure that children and pets don’t have access to any medications.

What if I miss a dose?

If you miss a dose of Zonisamide, take it as soon as you remember. Don’t take the missed dose if the time to take the next dose is almost up. Taking multiple doses near each other can lead to excess medication in your body which can be harmful.

What if I overdose?

In case of an overdose of Zonisamide, get emergency medical attention or call the Doctor Immediately. Overdose may lead to symptoms like slow heart rate, lightheadedness, fainting, or shortness of breath.

Things and Activities to Avoid while Taking Zonisamide

Zonisamide may impact your thinking capabilities and reflexes. So take extra care while indulging in activities that require a high degree of mental awareness and thinking such as driving. Alcohol consumption is not recommended while taking this medication.

Side Effects Due to Zonisamide

A serious side effect of Zonisamide is increased or worsening seizures. In such a scenario, stop using this medication and seek emergency medical attention. Some of the common side effects of Zonisamide are headache, diarrhea, loss of coordination, dizziness, drowsiness, loss of appetite vision problems, or nervousness. If any of these side effects deteriorate or persist for a long time, you must seek immediate medical attention. Zonisamide usage may lead to suicidal thoughts. You must notify your doctor about any new or deteriorating symptoms like mood or behavior changes, depression, anxiety, suicidal or self-hurting thoughts, increased agitation, hostility, restlessness, and hyperactivity (mentally or physically).

The side effects mentioned above are not the only ones that you may experience or witness due to Zonisamide. If you get any serious side effects due to this medication, contact your doctor right away.

Zonisamide Dosing Information

Zonisamide dosage may depend on a range of factors like age, sex, drug allergies, or seriousness of the condition among several other factors. Your dosage will be determined by your doctor after examining you properly. Remember to follow your doctor's advice properly for the best outcome.

Zonisep Capsule (Zonisamide) Interaction with other drugs

Let your doctor know in advance if you already use any of these drugs: Phenobarbital, cold or allergy drugs that contain an antihistamine, other anti-seizure or anti-convulsant drugs like carbamazepine, phenytoin, or topiramate. These drugs can interact with Zonisamide and affect its effectiveness or cause other undesirable effects. Also, tell your doctor about any other medications or related products that you use. Never start a new medicine without proper medical advice.

Expert advice

If your child (<12 years old) has been prescribed zonisamide, ask your doctor for necessary precautions, as they are at greater risk of reduced sweating, heat stroke, pneumonia, and liver problems.
Dress lightly during hot climates or when exercising and check carefully for signs of decreased sweating or heat stroke.
Drink sufficient water while taking zonisamide to reduce the risk of kidney stones and heart strokes.
Do not stop using zonisamide suddenly, even if you feel fine as stopping suddenly may cause increased seizures.
Seek immediate medical attention if you develop serious and sometimes fatal skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis), as zonisamide (sulfa medicine) is known to cause such side effects.
Inform your doctor and seek medical advice if you develop any signs of suicidal thoughts or actions, depressed mood, anxious state, restlessness, irritable behavior, or any unusual change in mood or behavior; high fever, or long-lasting fever.
Do not drive or operate machinery as zonisamide may cause dizziness, drowsiness, or vision changes.
Tell your doctor if you are planning to become pregnant or are breastfeeding.

Frequently asked questions

 Zonisep Capsule (Zonisamide) 

Q. Is zonisamide safe during pregnancy?

Zonisamide should only be used if the potential benefits justify the potential risk to the baby. Please follow your doctor's advice regarding its use.

Q. Is it safe to use zonisamide during breastfeeding?

Zonisamide should only be used if the potential benefits justify the potential risk to the baby. Please follow your doctor's advice regarding its use.

Q. Is zonisamide used for weight loss or migraines?

Zonisamide is not used to treat weight loss or migraines.

Q. Can I take ibuprofen/prednisone with zonisamide?

Yes, Ibuprofen or prednisone can be taken with zonisamide.

Q. Does zonisamide cause weight gain/ kidney stones/hair loss/ weight loss/ diarrhea/ depression/ constipation/feeling high?

Zonisamide commonly does not cause all the above-mentioned side effects except depression. Please consult your doctor if you develop such side effects.