Velpanat Tablet (Sofosbuvir + Velpatasvir) | Epclusa Alternative | Used to Treat Chronic Hepatitis C Virus (HCV) Infection
Velpanat Tablet is an aggregate of Sofosbuvir and Velpatasvir. It is used to treat continual (long-time period) hepatitis C (an ongoing viral contamination that damages the liver). Sofosbuvir and Velpatasvir are also sold under the brand name Epclusa.
Introduction Of Velpanat Tablet
Velpanat Tablet is a combination antiviral medicine containing Sofosbuvir (400 mg) and Velpatasvir (100 mg).
It is used to treat chronic hepatitis C virus (HCV) infection in adults of all six major genotypes.Velpanat works by blocking enzymes (NS5B and NS5A) that the hepatitis C virus needs to multiply. This helps clear the virus from the blood, reduces liver damage, and prevents complications such as liver cirrhosis or liver cancer.
Precautions Of Velpanat Tablet
- Use only under medical supervision.
- Inform your doctor if you have:
- Liver or kidney disease
- Hepatitis B virus co-infection
- Heart problems
- Avoid alcohol and other liver-harming substances.
- Not recommended during pregnancy unless prescribed.
- Discuss with your doctor before using while breastfeeding.
- Do not take with other antiviral medicines unless approved.
Usage Of Velpanat Tablet
- Used for the treatment of chronic hepatitis C virus (HCV) infection of all genotypes (1–6).
- Taken once daily with or without food, as directed by your doctor.
- Usually prescribed for 12 weeks (or longer in some cases).
- Do not skip doses — consistent daily use is essential for viral clearance.
- Avoid stopping the medicine unless told by your doctor.
Side Effects Of Velpanat Tablet
- Common:
- Headache
- Fatigue or tiredness
- Nausea
- Insomnia (difficulty sleeping)
- Diarrhea
FAQs Of Velpanat Tablet
Q1. What is Velpanat Tablet used for?
It is used to treat chronic hepatitis C virus infection in adults.
Q2. How long should I take Velpanat?
Usually for 12 weeks, but duration may vary based on your viral load and doctor’s advice.
Q3. Can I take Velpanat with food?
Yes, it can be taken with or without food.
Q4. Is Velpanat safe?
Yes, it is generally safe when taken under medical supervision.
Q5. Can I drink alcohol while taking Velpanat?
No. Alcohol can worsen liver damage and reduce treatment effectiveness.
Q6. What happens if I miss a dose?
Take it as soon as you remember. If it’s almost time for the next dose, skip the missed one — don’t double the dose.
Q7. Can Velpanat cure hepatitis C completely?
Yes, when taken correctly, it can eliminate the virus from the body in most cases.
Interactions Of Velpanat Tablet
- Velpanat may interact with:
- Rifampicin, Carbamazepine, Phenytoin – reduce its effectiveness.
- Amiodarone – may cause severe bradycardia (slow heart rate).
- Antacids / Proton Pump Inhibitors – reduce absorption of Velpatasvir (take 4 hours apart).
- Tenofovir-based HIV drugs – may increase side effects.
- Herbal supplements (St. John’s Wort) – avoid completely.
| Manufacturer | : | Natco Pharma, India |
| Trade Name | : | Epclusa |
| Generic Search | : | |
| Strength | : | 400mg + 100mg |





















