Tykerb Tablet (Lapatinib)

What is Tykerb?

Tykerb (lapatinib) is a cancer medication. Tykerb is used together with another medicine called capecitabine (Xeloda) or letrozole (Femara) to treat a certain type of advanced breast cancer that has spread to other parts of the body. It is often given after other cancer medications have been tried without successful treatment of symptoms. Tykerb may also be used for purposes not listed in this medication guide.

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Important information of Tykerb Tablet (lapatinib)

Do not use Tykerb if you are pregnant. It could harm the unborn baby. Before you take Tykerb, tell your doctor if you have heart disease, liver disease, an electrolyte imbalance (low potassium or magnesium), or a personal or family history of Long QT syndrome. To make sure you can safely take Tykerb, your heart function will need to be checked before you start treatment. Your liver function will need to be checked every 4 to 6 weeks during treatment. Take Tykerb on an empty stomach. Take this medication for the entire length of time prescribed by your doctor.

Uses of Tykerb Tablet (lapatinib)

Breast Cancer:  Lapatinib tablet is approved for use in combination with other medications for the treatment of advanced or metastatic breast cancer. It is specifically indicated for breast cancer that overexpresses a protein called HER2/neu, which promotes cancer cell growth.

HER2-Positive Metastatic Breast Cancer: Lapatinib tablet is used in combination with capecitabine, another chemotherapy drug, for the treatment of HER2-positive metastatic breast cancer that has progressed after prior treatment with other anti-HER2 therapies.

HER2-Positive Early Breast Cancer:  Lapatinib tablet, in combination with trastuzumab (another anti-HER2 therapy), may be used as part of a neoadjuvant treatment regimen for HER2-positive early breast cancer. Neoadjuvant therapy is given before surgery to shrink tumors and increase the chances of successful surgical removal.

Before taking this medicine

You should not use Tykerb if you are allergic to lapatinib. To make sure you can safely take Tykerb, tell your doctor if you have any of these other conditions: heart disease; liver disease; an electrolyte imbalance (such as low levels of potassium or magnesium in your blood); or a personal or family history of Long QT syndrome.

FDA pregnancy category D. Do not use Tykerb if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment. It is not known whether lapatinib passes into breast milk or if it could harm a nursing baby. You should not breastfeed while you are taking Tykerb.

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How should I take Tykerb Tablet (lapatinib)?

Take Tykerb exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Tykerb comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions. Be sure to also read the medication guide or patient instructions for capecitabine (Xeloda) or letrozole (Femara). Take Tykerb on an empty stomach, at least 1 hour before or 1 hour after a meal. The usual dose of Tykerb is equal to 5 or 6 tablets given at one time. The number of tablets you take will depend on your condition and whether you are also taking capecitabine (Xeloda) or letrozole (Femara).

Do not crush a Tykerb tablet. Swallow the pill whole. The medicine from a crushed or broken pill can be dangerous if it gets on your skin. If this occurs, wash your skin with soap and water and rinse thoroughly. You may swallow each Tykerb tablet one at a time, but take the entire dose (all 5 or 6 tablets) at the same time each day. Tykerb is usually taken together with capecitabine (Xeloda) in a 21-day cycle. Tykerb is given once daily for all 21 days in a row, and capecitabine is given twice daily for only the first 14 days of the cycle. This 21-day cycle is then repeated until your doctor decides that Tykerb is no longer an appropriate treatment for your condition. Follow your doctor's instructions. Capecitabine (Xeloda) must be taken with food or within 30 minutes of eating. Tykerb is usually taken together with letrozole (Femara) daily for as long as you continue to take letrozole. Take Tykerb for the full prescribed length of time. This medication is usually continued unless your condition gets worse or you have serious side effects.

Your heart function will need to be checked before you start treatment with Tykerb. To be sure this medication is not causing harmful effects, your liver function will need to be checked every 4 to 6 weeks. Visit your doctor regularly. Store Tykerb at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

What should I avoid?

Grapefruit and grapefruit juice may interact with Tykerb and lead to potentially dangerous effects. Avoid using these products while taking Tykerb.

Tykerb Tablet (lapatinib) side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Tykerb: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using Tykerb and call your doctor at once if you have serious side effects such as fast or pounding heartbeats; extreme dizziness or tired feeling; feeling like you might pass out; severe diarrhea; dry cough, feeling short of breath; white patches or sores inside your mouth or on your lips; nosebleeds; or nausea, pain in your upper stomach, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). Less serious Tykerb side effects may include mild diarrhea, upset stomach; pain or redness on the palms of your hands or the soles of your feet; dry skin, mild rash; unusual hair loss; or problems with your fingernails or toenails.

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What is this medicine?

LAPATINIB (la PA ti nib) is a medicine that targets proteins in cancer cells and stops the cancer cells from growing. It is used to treat some advanced breast cancers. It is often used along with other cancer treatments. This medicine may be used for other purposes; ask your healthcare provider or pharmacist if you have questions.

What should I tell my healthcare provider before I take this medicine?

They need to know if you have any of these conditions: -heart disease -heart rhythm problems (irregular heartbeat) -high blood pressure -history of low levels of potassium or magnesium -liver disease -an unusual reaction to lapatinib, other medicines, foods, dyes, or preservatives -pregnant or trying to get pregnant -breast-feeding

How should I use Tykerb Tablet (lapatinib) medicine?

Take this medicine by mouth with a glass of water. Take this medicine on an empty stomach, at least 1 hour before or after a meal. Do not take it with food. Follow the directions on the prescription label. Do not take your medicine more often than directed. Do not stop taking it except on your doctor's advice. Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed. This medicine is not approved for use in children. Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What should I watch for while using Tykerb Tablet (lapatinib) medicine?

Visit your doctor for checks on your progress. You will need to have regular blood tests while on this medicine. Report any new symptoms promptly. Let your doctor know if you have any change in bowel patterns, nausea, loss of appetite, or vomiting, as these side effects may cause dehydration. If you have shortness of breath, contact your doctor. Possible serious side effects include heart or lung problems. Do not become pregnant while taking this medicine. Women should inform their doctors if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your healthcare professional or pharmacist for more information. Do not breastfeed an infant while taking this medicine.

Where should I keep my medicine?

Keep out of the reach of children. Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from moisture. Keep tightly closed. Throw away any unused medicine after the expiration date. NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

Drug interaction with Tykerb Tablet (lapatinib)

Lapatinib tablets can potentially interact with other medications, and it's important to be aware of these drug interactions. Some common drug interactions with Lapatinib include:

CYP3A4 Inhibitors:  Medications that inhibit the enzyme CYP3A4 can increase the concentration of Lapatinib in the body, potentially leading to an increased risk of side effects. Examples of CYP3A4 inhibitors include ketoconazole, clarithromycin, and grapefruit juice. It is advisable to consult with your healthcare provider before starting any new medication while taking Lapatinib.

CYP3A4 Inducers:  On the other hand, medications that induce the activity of CYP3A4 can decrease the concentration of Lapatinib in the body, reducing its effectiveness. Rifampin and St. John's wort are examples of CYP3A4 inducers. Your healthcare provider can guide you on managing the use of these medications along with Lapatinib.

QT Prolonging Drugs: Lapatinib has the potential to prolong the QT interval on an electrocardiogram, which can increase the risk of cardiac arrhythmias. Therefore, caution should be exercised when using Lapatinib in combination with other drugs that also have the potential to prolong the QT interval, such as certain antiarrhythmics and antipsychotics. Close monitoring and consultation with a healthcare provider are recommended.

Other Cancer Medications: Lapatinib may interact with other cancer medications, such as paclitaxel or trastuzumab, which are commonly used in combination therapy for breast cancer. Your healthcare provider will carefully consider these potential interactions and adjust the treatment plan accordingly.

FAQs:

Tykerb Tablet (lapatinib)

Q: Can Lapatinib tablets be taken by elderly patients?

A: Lapatinib tablets can be taken by elderly patients, but dosage adjustments may be necessary based on individual health considerations. It is important for elderly patients to work closely with their healthcare providers to ensure safe and effective use of the medication.

Q: Can Lapatinib tablet cure cancer?

A: Lapatinib tablet is not a cure for cancer, but it can help in the management and treatment of certain types of cancer, particularly breast cancer. It is used as part of a comprehensive treatment approach that may include surgery, radiation therapy, and other medications.

Q: Can Lapatinib tablets be used in pediatric patients?

A: The use of Lapatinib tablets in pediatric patients is limited and generally not recommended. The safety and efficacy of the medication in children have not been extensively studied. Treatment decisions for pediatric patients should be made in consultation with a pediatric oncologist.