Cytogard Tablet – Trimetazidine 20mg | Anti-anginal Medicine – Used to Treat Heart-related Chest Pain (Angina)

Precautions of Trimetazidine Tablet

• Inform your doctor if you have any known allergies to Trimetazidine or any other medications. This is important to avoid any potential allergic reactions.
• If you have liver or kidney disease, it is crucial to inform your doctor. Dose adjustments may be necessary to prevent any complications or adverse effects.
• If you are pregnant or breastfeeding, it is important to consult with your doctor before taking Trimetazidine. They will evaluate the potential risks and benefits for you and your baby.
• Make sure to inform your doctor about any other medical conditions you have, such as diabetes or Parkinson's disease, as Trimetazidine may interact with certain medications used to treat these conditions.
• Trimetazidine may cause dizziness or drowsiness in some individuals. If you experience these side effects, avoid activities that require mental alertness, such as driving or operating heavy machinery.
• It is advisable to limit or avoid alcohol consumption while taking Trimetazidine, as it may increase the risk of side effects.

Uses of Trimetazidine Tablet (Cytogard)

Trimetazidine for angina: Trimetazidine 20mg is used for symptomatic treatment of stable angina (chest pain) as an additional therapy to other frontline medicines.

THERAPEUTIC INDICATIONS

This drug is recommended in:
Preventive treatment for episodes of angina pectoris (Chronic stable angina).
Adjuvant symptomatic treatment for vertigo and tinnitus (noises detected by the ear whistling, and buzzing, which do not correspond to any exterior sounds).
Adjuvant treatment of visual disorders of a circulatory origin.

CONTRAINDICATIONS of Trimetazidine Tablet
Do not take Vastarel MR if you are allergic to any of the constituents.
This drug is generally not recommended during breastfeeding

Side Effects of Trimetazidine Tablet

As with all drugs, Vastarel MR is likely to have undesirable effects:

Rare cases of gastrointestinal disorders (nausea, vomiting)
If you notice any undesirable effects, which have not been mentioned here, you should inform your doctor or pharmacist.

Pregnancy
It is preferable not to take this medicine during pregnancy, if you discover that you are pregnant whilst taking this medicine, consult your doctor as he alone can judge the necessity of continuing your treatment

Breastfeeding
In the absence of data on excretion in breast milk, breastfeeding is not recommended during treatment. Ask your doctor or pharmacist's advice before taking any medicine.

FAQ’s

Q. Is trimetazidine available in the USA?
No, trimetazidine is not available in the USA.

Q. Is trimetazidine available in Canada?
No, trimetazidine is not available in Canada.

Q. What is trimetazidine/ trimetazidine dihydrochloride used for?
Trimetazidine is used in the treatment of angina pectoris (sensation of pressure, squeezing, or pain in the chest due to insufficient blood supply to the muscles of the heart) as an additional therapy to other frontline medicines. It may also be used in patients who do not respond well to other anti-anginal medicines.

Q. How does trimetazidine work?
Trimetazidine belongs to the metabolic modulators class of medicines, also known as pFOX inhibitors (partial fatty-acid-oxidation inhibitors). In the myocardium (muscles of the heart), trimetazidine partially inhibits the metabolic process (?-oxidation) of fatty acid that requires more oxygen consumption) blocking a specific enzyme (long-chain 3-ketoacyl-CoA thiolase) and triggering glucose oxidation requires less oxygen consumption. Angina is caused by decreased oxygen supply to the heart's cells due to reduced blood flow. Trimetazidine, thus, triggers processes that increase cellular energy (potentiation of glucose oxidation), thereby acting by preserving the myocardial high-energy and making oxygen available for the cells of the heart.

Interaction

• Avoid with Parkinson’s medications (e.g., levodopa) – may worsen motor symptoms.
• Use cautiously with beta-blockers and calcium channel blockers – monitor for combined cardiovascular effects.
• Dose adjustment needed in kidney impairment – cleared renally.
• Generally safe with nitrates, antiplatelets, and statins – commonly used together in angina treatment.
• Always consult a doctor before combining with other heart or neurological medications.