Clariface Tablet (Clarithromycin) | Used for Respiratory Tract Infections and Bacterial Diseases
Clariface Tablet (Clarithromycin) is a macrolide antibiotic used to treat various bacterial infections, including respiratory tract infections, sinusitis, skin infections, and H. pylori-related ulcers.
Product Overview
Clariface Tablet is an advanced, broad-spectrum macrolide antibiotic formulated with Clarithromycin to eliminate a wide array of stubborn bacterial infections. Known for its excellent tissue penetration and stability against bacterial defense mechanisms, this medication is widely utilized in clinical medicine to target infections of the respiratory tract, throat, middle ear, and skin structures. Additionally, it serves as a cornerstone molecule in multi-drug therapeutic regimens designed to eradicate deep gastric bacterial pathogens and treat opportunistic infections in immunocompromised individuals.
Product Composition
- Active Antibiotic Ingredient: Clarithromycin (available in standard strengths of 250 mg and 500 mg)
- Core Matrix Binders: Microcrystalline Cellulose, Starch, and Povidone
- Structural Disintegrants: Croscarmellose Sodium and Sodium Starch Glycolate
- Lubricants & Glidants: Magnesium Stearate, Colloidal Silicon Dioxide, and Purified Talc
- External Film-Coating: Hypromellose, Titanium Dioxide, and Polyethylene Glycol
Product Specification
| Feature | Detail |
| Dosage Form | Film-Coated Oral Compressed Tablet |
| Therapeutic Class | Macrolide Antibiotic |
| Antibacterial Spectrum | Gram-positive aerobes, select Gram-negative aerobes, anaerobes, and atypical intracellular pathogens |
| Storage Parameters | Store below 25 Degrees Celsius in a dry environment protected from light |
Mechanism of Action
- Ribosomal Subunit Binding: Binds reversibly to the 50S ribosomal subunit of susceptible bacterial cells at specific amino acid positions.
- Protein Synthesis Blockade: Inhibits the vital transpeptidation and translocation steps, preventing the extension of the peptide chain and halting bacterial protein synthesis.
- Peptidyl-tRNA Dissociation: Stimulates the premature separation of peptidyl-tRNA molecules from the active ribosome sites, rendering the cell unable to perform essential life functions.
- Bacteriostatic and Bactericidal Action: Effectively arrests bacterial replication and multiplication, working in harmony with the body's natural immune defense mechanisms to achieve pathogen clearance.
Key Benefits
- Superior Tissue Penetration: Accumulates rapidly within mucosal fluids, lung tissues, tonsils, and inflammatory cells, achieving local concentrations several times higher than circulating plasma levels.
- High Stability Design: Exhibits exceptional structural resilience in acidic gastric environments, ensuring reliable systemic absorption and consistent biological availability.
- Atypical Pathogen Coverage: Provides reliable therapeutic coverage against atypical, intracellular organisms such as Mycoplasma pneumoniae and Chlamydia pneumoniae, which escape standard penicillins.
- Streamlined Dosing Schedules: Possesses a prolonged elimination half-life that supports an efficient twice-daily layout, which enhances routine compliance and treatment success.
Precautions
Important Safety Information Before Using Clariface Tablet
Clariface Tablet (Clarithromycin) should be used carefully to ensure effective bacterial infection treatment and to reduce the risk of unwanted effects.
| Precaution | Details |
|---|---|
| Allergy Check | Avoid if allergic to macrolide antibiotics |
| Complete Course | Finish the full antibiotic course |
| Liver Health | Inform about liver conditions |
| Drug Timing | Take at same time daily |
| Food Intake | May be taken with or without food |
| Drug Resistance | Do not skip or misuse doses |
| Medical History | Inform about heart rhythm issues |
| Regular Monitoring | Watch for unusual symptoms |
Use Carefully In
- Patients with liver disease
- Individuals with heart rhythm disorders
- Elderly patients
- People with antibiotic sensitivity
Storage Instructions
- Store in a cool and dry place
- Keep away from moisture and heat
- Protect from direct sunlight
- Keep out of reach of children
Helpful Usage Tips
- Take doses exactly as prescribed
- Do not stop early even if feeling better
- Maintain good hygiene during treatment
- Avoid self medication with other antibiotics
Usage
Administration
Take with or without Food: Swallow the tablet whole with a glass of water. It can be taken either on an empty stomach or with a meal, though taking it with food can help reduce mild stomach upset.
Maintain Fixed Intervals: Space your doses exactly twelve hours apart to keep a steady, uninterrupted concentration of clarithromycin circulating within the bloodstream.
Swallow in Entirety: Do not crush, chew, or split the film-coated tablet matrix, as breaking the exterior coating can expose the bitter active drug or alter its release.
Complete the Full Course: Finish every tablet in the assigned layout even if symptoms vanish early, ensuring the target pathogen is fully cleared and preventing antibiotic resistance.
Avoid Mineral Interactions: Do not take this medication simultaneously with iron supplements, zinc supplements, or magnesium-containing antacids, as minerals can reduce its absorption.
Dosage
| Patient Profile | Administration Plan |
| Standard Adult Routine | Typically administered as 250 mg to 500 mg twice daily for seven to fourteen days depending on infection depth. |
| Renal Impairment Adjustment | Doses are reduced or the interval is extended when severe kidney filtration reduction is confirmed. |
| Missed Application Rule | Take the missed dose immediately if remembered within a few hours, otherwise skip to stay on the standard timeline; never double the dose. |
Uses
Respiratory and Throat Care
Acute Bronchitis and Pneumonia: Penetrates deep into lung tissue and bronchial secretions to eliminate bacteria causing community-acquired pneumonia and worsening bronchitis.
Sinusitis and Tonsillitis: Clears severe infections of the paranasal sinuses and tonsils, reducing swelling, throat pain, and localized inflammation.
Atypical Mycobacterial Infections: Treats and prevents disseminated infections caused by Mycobacterium avium complex in specialized clinical settings.
Gastrointestinal and Skin Care
Helicobacter Pylori Eradication: Acts as a core component in multi-drug combinations to eliminate H. pylori bacteria from the gastric mucosa, promoting the healing of peptic ulcers.
Skin and Soft Tissue Support: Resolves localized subcutaneous infections, mild cellulitis, and folliculitis by targeting sensitive Gram-positive pathogenic bacteria.
Side Effects
Possible Side Effects of Clariface Tablet
Clariface Tablet (Clarithromycin) may cause some side effects during bacterial infection treatment. Most are mild and temporary, but some may require medical attention.
| Side Effect | Details |
|---|---|
| Nausea | Mild stomach upset |
| Vomiting | Feeling of sickness |
| Diarrhea | Loose stools |
| Abdominal Pain | Stomach discomfort |
| Headache | Mild head pain |
| Taste Disturbance | Altered or metallic taste |
| Indigestion | Bloating or acidity |
| Dizziness | Lightheaded feeling |
Less Common Side Effects
- Skin rash or allergic reactions
- Liver enzyme changes
- Severe diarrhea (rare)
- Irregular heartbeat
How to Reduce Side Effects
- Take with food if stomach upset occurs
- Stay well hydrated during treatment
- Avoid skipping doses
- Complete full antibiotic course
When to Seek Medical Attention
- Severe diarrhea or abdominal pain
- Yellowing of skin or eyes
- Irregular heartbeat or chest pain
- Severe allergic reaction or swelling
FAQs
Q: What is Clariface Tablet used for?
A: It is used to treat bacterial infections of the respiratory tract, skin, and soft tissues, including pneumonia, bronchitis, sinusitis, tonsillitis, and pharyngitis. It is also used in H. pylori eradication therapy for peptic ulcers and in the prevention and treatment of MAC infections in immunocompromised patients.
Q: How does Clarithromycin work?
A: It works by inhibiting bacterial protein synthesis, preventing bacteria from growing and multiplying. This ultimately leads to the elimination of the infection-causing bacteria from the body.
Q: How should Clariface Tablet be taken?
A: It should be taken orally with or without food as prescribed by the doctor. Extended-release tablets should be taken with food and must not be crushed or chewed. Follow the prescribed dose and duration consistently for best results.
Q: How long does treatment usually last?
A: Treatment duration typically ranges from 7 to 14 days depending on the type and severity of the infection. For H. pylori eradication, it is usually taken as part of a combination therapy for 10 to 14 days.
Q: What are the common side effects?
A: Common side effects include nausea, diarrhea, stomach upset, vomiting, abnormal or metallic taste in the mouth, and headache. If severe diarrhea or signs of allergic reaction occur, contact your doctor immediately.
Q: Can Clariface Tablet interact with other medications?
A: Yes, Clarithromycin has significant interactions with many medications including statins, blood thinners, antiarrhythmics, and certain antihistamines. Always inform your doctor of all medications you are currently taking before starting treatment.
Q: Can it be used in children?
A: Yes, Clarithromycin can be used in children under medical supervision, with dosage adjusted according to body weight. It is also available in oral suspension form for younger children who cannot swallow tablets.
Q: Can stopping treatment early cause antibiotic resistance?
A: Yes, stopping treatment before completing the full prescribed course can allow surviving bacteria to develop resistance, making future infections harder to treat. Always complete the full course as directed by your doctor.
Interactions
Possible Interactions with Clariface Tablet
Clariface Tablet (Clarithromycin) may interact with several medicines and substances. These interactions can affect drug levels, increase side effects, or reduce treatment effectiveness.
| Product Type | Possible Effect |
|---|---|
| Statins | Increased risk of muscle damage |
| Blood Thinners | Increased bleeding risk |
| Heart Rhythm Medicines | May affect heart rhythm (QT prolongation) |
| Antifungal Medicines | Increased drug concentration levels |
| Anti Seizure Medicines | Reduced antibiotic effectiveness |
| HIV Medicines | Altered drug levels and side effects |
| Antacids | May reduce absorption if taken together |
| Ergot Medicines | Risk of serious toxicity |
Use Carefully With
- Multiple antibiotic treatments
- Long term cardiac medications
- Liver metabolized medicines
- Drugs affecting heart rhythm
Helpful Monitoring Tips
- Inform about all ongoing medicines
- Monitor for unusual heart symptoms
- Avoid self combining antibiotics
- Follow complete treatment schedule
When to Seek Medical Attention
- Irregular heartbeat or chest discomfort
- Severe diarrhea or abdominal pain
- Yellowing of skin or eyes
- Allergic reactions or swelling
| Manufacturer | : | Healing Pharma |
| Trade Name | : | Biaxin |
| Generic Search | : | Clarithromycin |
| Strength | : | 250mg , 500mg |
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