Calborol Injection (Calcium Borogluconate) Used to Treat Hypocalcemia (Low Blood Calcium Levels) in Livestock and Other Animals
Calborol Veterinary Injection is a medicine used in veterinary medicine to treat hypocalcemia (milk fever) and calcium deficiencies in in livestock and other animals. It helps restore normal calcium levels in the body, supporting proper muscle function, nerve activity, and bone health.
Product Overview
Calborol Injection is a sterile veterinary injection formulated for the treatment of hypocalcemia (milk fever) and calcium deficiencies in animals. Calborol Veterinary Injection combination product contains calcium and boro gluconate, which are both essential for proper bone formation, muscle function, nerve function, and blood clotting. Calcium is an essential mineral that plays a crucial role in many biological processes. It is necessary for the proper functioning of the heart, muscles, and nervous system, and it is also needed for bone and tooth development. Borogluconate is a compound that helps the body absorb calcium more efficiently, making it an effective treatment for calcium deficiencies. It serves as a critical intervention for metabolic emergencies where a sudden drop in blood calcium occurs. This injectable treatment is engineered for high bioavailability, allowing for the quick restoration of calcium levels to ensure normal nerve conduction and muscle function. It is a staple in veterinary medicine for stabilizing animals during critical recovery periods.
Product Composition
The efficacy of this injection is centered on its highly soluble calcium source:
- Calcium Borogluconate: A specialized form of calcium prepared with boric acid to increase its solubility and stability, making it safe and effective for parenteral administration.
Product Specification
| Feature | Details |
| Therapeutic Class | Parenteral Mineral Supplement |
| Administration Route | Intravenous (IV) or Subcutaneous (SC) |
| Primary Indication | Hypocalcemia (Milk Fever) |
| Target Species | Cattle, Sheep, Goats, and Horses |
| Storage | Store in a cool, dry place; protect from light |
Mechanism of Action
Calborol Injection works by immediately increasing the concentration of calcium ions in the extracellular fluid, which is vital for multiple biological systems:
- Neuromuscular Stabilization: Calcium ions are essential for the release of neurotransmitters. By restoring calcium levels, the injection enables proper communication between nerves and muscles, reversing paralysis.
- Myocardial Support: It ensures the heart muscle has the necessary minerals to maintain rhythmic contractions and adequate cardiac output.
- Metabolic Equilibrium: The infusion helps stabilize the internal environment, preventing the systemic "shutdown" associated with acute mineral depletion during peak lactation or late pregnancy.
- Enzyme Activation: Calcium acts as a secondary messenger and a cofactor for various enzymes involved in blood clotting and energy metabolism.
Key Benefits
- Rapid Clinical Response: Designed for emergency use, it provides an almost immediate improvement in animals suffering from acute calcium deficiency.
- Superior Solubility: The borogluconate form ensures the calcium remains in a clear solution that is easily absorbed by the body without the risk of crystallization.
- Versatile Delivery: Can be administered through different routes depending on the urgency of the condition and the specific needs of the animal.
- Support for High-Producing Livestock: Helps maintain the health of dairy animals during the transition period when the demand for calcium is at its highest.
- Essential for Critical Care: Effectively treats "Downer Cow" syndrome, allowing animals to regain their strength and standing posture more quickly.
Precautions
Calborol Injection (Calcium Borogluconate) should be used carefully under veterinary supervision to ensure safe and effective correction of calcium deficiency in animals.
Animal Health Conditions to Inform Veterinarian
| Condition | Why It Matters |
|---|---|
| Heart disease or cardiac dysfunction | Calcium can affect heart rhythm and function |
| Kidney disease | Impaired calcium excretion may lead to toxicity |
| Hypercalcemia (high calcium levels) | Risk of worsening calcium imbalance |
| Dehydration | May increase risk of adverse reactions |
| Chronic illness or metabolic disorders | Requires dose adjustment and monitoring |
Administration Precautions
- Administer only as prescribed by a veterinarian
- Use proper injection technique (IV/IM as directed)
- Do not exceed recommended dosage
- Ensure slow administration to avoid cardiac complications
Monitoring and Safety
- Monitor heart rate and general condition during and after injection
- Watch for signs of hypercalcemia such as weakness or irregular heartbeat
- Repeat dosing only under veterinary guidance
Pregnancy and Lactation (Animals)
- Often used in pregnant or lactating animals under veterinary supervision
- Extra caution required in high-risk cases such as milk fever
General Advice
- Keep out of reach of children and unauthorized handlers
- Store as per label instructions to maintain stability
- Do not self-administer without veterinary guidance
- Always consult a veterinarian for correct diagnosis and dosage
Usage
The administration of Calborol Injection must be handled with care, preferably by a veterinary professional, to ensure the safety of the animal and the effectiveness of the mineral replacement.
Dosage & Administration
Dosage is determined by the species, weight of the animal, and the severity of the calcium deficiency. It is essential to monitor the animal’s heart rate throughout the administration process.
| Aspect | Recommendation |
| Standard Route | Intravenous (IV) or Subcutaneous (SC) |
| Infusion Speed | Must be administered slowly to avoid cardiac stress |
| Temperature | Solution should be warmed to body temperature before use |
| Repeat Treatment | A second dose may be given after several hours if required |
Administration
Slow Intravenous Infusion: When given intravenously, the injection should be administered slowly over a period of 10 to 20 minutes. Rapid administration can lead to heart arrhythmias or cardiac arrest.
Subcutaneous Technique: If administered under the skin, the dose should be divided among several different injection sites to prevent localized irritation and ensure better absorption.
Aseptic Precautions: Use sterile needles and syringes and thoroughly clean the injection site to prevent the risk of infection or abscess formation.
Observation: Monitor the animal closely during and after the injection. Signs of recovery typically include improved muscle tone, localized sweating on the muzzle, and the ability to stand.
Uses
Calborol Injection is a vital veterinary treatment used to manage acute metabolic disorders caused by mineral imbalances in livestock.
Treatment of Milk Fever (Parturient Paresis): It is the primary treatment for dairy cows and other livestock experiencing acute hypocalcemia shortly before or after giving birth.
Management of Grass Tetany: Used in conjunction with magnesium supplements to treat "staggers" caused by low mineral levels in animals grazing on lush spring pastures.
Correction of Eclampsia: Indicated for the treatment of "milk tetany" in lactating ewes, goats, and mares.
Support for Downer Cow Syndrome: Helps in the recovery of animals that are unable to rise due to prolonged mineral deficiency or metabolic exhaustion.
Symptomatic Relief of Allergies: In some veterinary practices, it is used as a supportive therapy for acute allergic reactions or skin conditions like urticaria.
FAQ
Q: What is Calborol Veterinary Injection used for?
A: Calborol Veterinary Injection is primarily used in veterinary medicine to treat hypocalcemia (low blood calcium levels) in livestock and other animals.
Q: How is Calborol Veterinary Injection administered?
A: Calborol Veterinary Injection is administered via intravenous injection, under the guidance of a veterinarian.
Q: Can Calborol Veterinary Injection be used in all animals?
A: Calborol Veterinary Injection is intended for use in livestock and other animals as directed by a veterinarian. It should not be used in humans.
Q: What should I do if I suspect my animal is having an adverse reaction to Calborol Veterinary Injection?
A: If you notice any unusual symptoms or behavior in your animal after administering Calborol Veterinary Injection, contact your veterinarian immediately.
Q: Is Calborol Veterinary Injection safe for pregnant or lactating animals?
A: The safety of Calborol Veterinary Injection in pregnant or lactating animals has not been fully established. Consult with a veterinarian before administering this medication to animals in these conditions.
Q: How should Calborol Veterinary Injection be stored?
A: Calborol Veterinary Injection should be stored at room temperature, between 15-30°C (59-86°F), and protected from light. It should be kept out of reach of children and animals.
| Manufacturer | : | Elanco |
| Trade Name | : | |
| Generic Search | : | Calcium Borogluconate |
| Strength | : | 450ml |
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