Acabrunat Capsule (Acalabrutinib)
Acabrunat Capsule (Acalabrutinib) is a BTK inhibitor used in blood cancers like CLL, SLL, and MCL to slow cancer growth by blocking cell signaling pathways.
Introduction of Acabrunat Capsule (Acalabrutinib)
Acabrunat Capsule contains Acalabrutinib, a modern targeted anticancer medicine belonging to the class of Bruton’s Tyrosine Kinase (BTK) inhibitors. It is primarily used in the treatment of certain B-cell blood cancers, where abnormal white blood cells grow uncontrollably and affect normal body function. Unlike traditional chemotherapy, Acabrunat works in a more specific and targeted manner, focusing on cancer cell signaling pathways rather than killing all rapidly dividing cells in the body.
Acalabrutinib works by selectively blocking the BTK enzyme, which plays a key role in the survival, growth, and spread of cancerous B-lymphocytes. By inhibiting this enzyme, the medicine disrupts cancer cell communication, reduces abnormal cell proliferation, and helps slow disease progression. Over time, this helps improve disease control and reduces symptoms associated with blood cancers such as fatigue, swollen lymph nodes, and frequent infections.
Precautions of Acabrunat Capsule (Acalabrutinib)
- Increased risk of bleeding
- Risk of serious infections
- Not recommended in severe liver disease without supervision
- Inform doctor before surgery or dental procedures
- Regular blood count monitoring required
- Avoid live vaccines during treatment
- Use caution in patients with heart rhythm problems
Uses of Acabrunat Capsule (Acalabrutinib)
- Chronic Lymphocytic Leukemia (CLL)
- Small Lymphocytic Lymphoma (SLL)
- Mantle Cell Lymphoma (MCL)
Side Effects of Acabrunat Capsule (Acalabrutinib)
Common Side Effects:
- Headache
- Diarrhea
- Fatigue
- Muscle or joint pain
- Nausea
- Bruising
- Mild infections
Serious Side Effects:
- Severe bleeding
- Irregular heartbeat (atrial fibrillation)
- Serious infections
- Low blood cell counts (anemia, low platelets, low WBC)
- Liver problems
- Allergic reactions
FAQs of Acabrunat Capsule (Acalabrutinib)
1. What is Acabrunat Capsule used for?
It is used to treat blood cancers such as CLL, SLL, and MCL.
2. How does Acabrunat work?
It blocks BTK enzyme, stopping cancer cell growth and survival.
3. Is Acabrunat chemotherapy?
No, it is a targeted therapy, not traditional chemotherapy.
4. What are the common side effects?
Headache, fatigue, diarrhea, nausea, and mild infections.
5. Can Acabrunat cause bleeding?
Yes, it may increase the risk of bleeding, so caution is needed.
6. Can it be taken with antacids?
Yes, but with timing adjustment as it may affect absorption.
7. Is Acabrunat safe long-term?
It is used long-term under strict medical supervision with regular monitoring.
Interactions of Acabrunat Capsule (Acalabrutinib)
Acabrunat may interact with:
- Ketoconazole, itraconazole (antifungals)
- Clarithromycin, erythromycin (antibiotics)
- Rifampin (TB medicine)
- Carbamazepine, phenytoin (antiepileptics)
- Proton pump inhibitors (omeprazole, pantoprazole)
- Antacids (aluminium/magnesium-based)
- Blood thinners (warfarin, aspirin)
- St. John’s Wort
- Grapefruit products
| Manufacturer | : | Natco Pharma, India |
| Trade Name | : | Calquence |
| Generic Search | : | Acalabrutinib |
| Strength | : | 100mg |
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