Dicorate ER Tablet (Divalproex Sodium)

What is Divalproex Sodium?

Divalproex Sodium, also sold under several trade names such as Depakote ER and Dicorate ER (made by Sun Pharma is an anti-convulsant medication that affects certain body chemicals that can cause seizures. It is prescribed for the treatment of various types of seizure disorders. Divalproex Sodium is often used in combination with other anti-convulsant or anti-seizure medications.

Dicorate ER Tablet (Divalproex Sodium) is a medication commonly prescribed as a mood stabilizer for individuals experiencing mood disorders, specifically bipolar disorder. It is an extended-release tablet that contains the active ingredient Divalproex Sodium, which belongs to a class of drugs known as anticonvulsants. This medication is primarily used for manic episode prevention, which is characterized by periods of elevated mood, excessive energy, and impulsive behavior. Dicorate ER Tablet helps in regulating mood swings, reduces the intensity and frequency of manic episodes, and promotes stability in individuals with bipolar disorder. It is typically prescribed as part of a comprehensive treatment plan that may include therapy, lifestyle changes, and other medications.

Dicorate ER Tablet (Divalproex Sodium) Uses

Divalproex is used to treat mood disorders (mania), fits (complex partial seizures), and headaches due to migraine.

How it works

Divalproex belongs to the group of medicines called anticonvulsants. It acts by reducing or preventing the number of seizures and by controlling the abnormal activity of nerve signals in the brain.

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Precautions of Dicorate ER Tablet (Divalproex Sodium)

Do not take Divalproex Sodium anti convulsant or anti-seizure medication (Depakote ER, Dicorate ER) if you are allergic to it or any of its ingredients, or if you have liver disease or a urea cycle disorder. Divalproex Sodium is known to cause life-threatening liver failure in rare cases, especially in children who are younger than 2 years of age. Children of that age maybe even at a higher risk for liver problems if they take more than one seizure medication if they have a metabolic disorder, or if they have a brain disease causing mental impairment (Huntington's disease, Creutzfeldt-Jacob disease, multiple sclerosis, or a brain injury or infection). Divalproex Sodium is also reported to have caused life-threatening pancreatitis (inflammation of the pancreas) in rare cases. Pancreatitis can occur all of a sudden and you may see symptoms even after you have been taking this medication for several years.

You must get emergency medical attention if you experience nausea, vomiting, upper stomach pain, loss of appetite, dark urine, low fever, clay-colored stools, or jaundice while taking Divalproex sodium. These may be initial symptoms of liver damage or pancreatitis.

You must notify your doctor in advance, for safe usage of Divalproex if you have any of the following conditions: liver disease, a history of head injury, brain disorder, or coma; a bleeding or blood clotting disorder; a family history of a urea cycle disorder or infant deaths with unknown cause; or HIV or CMV (cytomegalovirus) infection. Divalproex Sodium usage may lead to suicidal thoughts. This side effect may require you to undergo regular follow-up checks by your doctor. You must notify your doctor about any new or deteriorating symptoms like mood or behavior changes, depression, anxiety, or suicidal or self-hurting thoughts during the initial few months of the treatment, or whenever your dose is changed.

Divalproex Sodium is categorized as a pregnancy category D drug which means it can cause birth defects if taken while pregnant. Do not take this medication without proper medical advice if you are pregnant or plan to become pregnant. Look for safer anti-convulsant medications that may be safer to take during pregnancy. Ask your doctor about this. Also, while using Divalproex Sodium medication, a proper birth control measure is recommended. This medication can pass into breast milk and harm a nursing baby. Therefore if you are breastfeeding, do not take Divalproex Sodium medication without first consulting a doctor.

Divalproex Sodium may impact cognitive development in children born to mothers who have used this medication during pregnancy. It has been observed through studies that such children score lower on cognitive tests (reasoning, intelligence, and problem-solving) than children whose mothers took other seizure medications during their pregnancy.

Before taking Divalproex Sodium

Keep in mind all precautions and points listed above before taking Divalproex Sodium anti convulsant medication (Depakote ER, Dicorate ER) and discuss them with your doctor for more clarification.

How should I take Divalproex Sodium?

Take Divalproex Sodium anti convulsant medication (Depakote ER, Dicorate ER) strictly according to your doctor's direction or according to the instructions on the medication label. Do not alter the dosage unless your doctor advises you to do so.

Avoid crushing, breaking, or chewing a Divalproex extended-release (ER) tablet as doing so may lead to too much of the medicine being released at once. Instead swallow it whole. You must ensure to drink plenty of fluids while taking this medication. Always store Divalproex Sodium anti convulsant medication in a cool and dry place.

What if I miss a dose?

If you miss a dose of Divalproex Sodium, take it as soon as you remember. Don’t take the missed dose if the time to take the next dose is almost up. Taking multiple doses near to each other can lead to excess medication in your body which can be harmful.

What if I overdose?

In case of an overdose of Divalproex Sodium, get emergency medical attention or call the Doctor immediately. Overdose may lead to symptoms like sleepiness, drowsiness, shortness of breath, weak pulse, or unconsciousness.

Things and Activities to Avoid while Taking Divalproex Sodium

Divalproex Sodium may impact your thinking capabilities and reflexes. So take extra care while indulging in activities that require a high degree of mental awareness and thinking such as driving. Alcohol is not recommended while taking Divalproex Sodium.

Side Effects Due to Divalproex Sodium

Divalproex Sodium (Depakote ER, Dicorate ER) is known to cause life-threatening liver failure in rare cases, especially in children who are younger than 2 years of age. Children of that age maybe even at a higher risk for liver problems if they take more than one seizure medication if they have a metabolic disorder, or if they have a brain disease causing mental impairment (Huntington's disease, Creutzfeldt-Jacob disease, multiple sclerosis, or a brain injury or infection). Divalproex Sodium is also reported to have caused life-threatening pancreatitis (inflammation of the pancreas) in rare cases. Pancreatitis can occur all of a sudden and you may see symptoms even after you have been taking this medication for several years.

You must get emergency medical attention if you experience nausea, vomiting, upper stomach pain, loss of appetite, dark urine, low fever, clay-colored stools, or jaundice while taking Divalproex sodium. These may be initial symptoms of liver damage or pancreatitis.

Divalproex Sodium usage may lead to suicidal thoughts. You must notify your doctor about any new or deteriorating symptoms like mood or behavior changes, depression, anxiety, suicidal or self-hurting thoughts, increased agitation, hostility, restlessness, and hyperactivity (mentally or physically).

Divalproex Sodium Dosing Information

Divalproex Sodium dosage may depend on a range of factors like age, sex, drug allergies, or seriousness of the condition among several other factors. Your dosage will be fixed by your doctor after examining you properly. Remember to obey your doctor strictly for the best results.

Dicorate ER Tablet (Divalproex Sodium) Interaction with other Medications

Some sleep-inducing medications like cold or cough medicines, narcotic painkillers, sleeping pills, antidepressants, or muscle relaxers can add to the sleepiness caused due to Divalproex Sodium. Let your doctor know in advance if you use any of these medicines. Also inform your doctor if you use any of these potentially interacting (with Divalproex Sodium) medications: Topiramate, a blood thinner such as warfarin, tolbutamide, aspirin or acetaminophen, clozapine, diazepam, ethosuximide, meropenem, or rifampin.

The list of drugs mentioned here in this guide is not a complete list of interacting medications (with Divalproex Sodium). There may be others as well. Share the list of all present medications which you may be using with your doctor. Never start a new medication on your own.

Expert advice

Do not take Divalproex tablets if you are allergic (hypersensitive) to Divalproex or any of the other ingredients of the Divalproex tablet.
Avoid taking Divalproex if you are pregnant or breastfeeding.
Do not take divalproex if you have a family history of urea cycle disorder or unexplained infant deaths; a history of mental or mood problems (e.g. depression) or suicidal thoughts or actions; if you have recurring vomiting and sluggishness, recurring extreme irritability, or decreased food or fluid intake.
Do not drive or operate machinery after taking Divalproex because you may feel drowsy.
Doctor’s advice should be considered in case of patients with the following history of disease conditions: cancer, alcohol abuse or dependence, liver problems, metabolic disease, blood disease (e.g. low levels of white blood cells, low blood platelet levels), HIV infection, cytomegalovirus (CMV) infection, high blood levels of ammonia or glutamine, low body temperature, low levels of albumin, brain problems, mental retardation, inflammation of the pancreas, kidney problems, or high blood glycine levels.

Frequently asked questions

Dicorate ER Tablet (Divalproex Sodium)

Q. Is divalproex the same as Depakote?

Yes, Depakote is the trading name of the product containing the drug Divalproex sodium.

Q. Is Divalproex safe?

Divalproex is safe if used at the prescribed dose and duration as advised by the doctor.

Q. Is divalproex the same as valproic acid?

No, divalproex contains a compound of sodium valproate and valproic acid.

Q. Is Divalproex addictive?

No, it is not addictive if used at the prescribed dose and duration as advised by your doctor.

Q. Can I take ibuprofen with divalproex?

Yes, but taking other medicines may alter the effects of Divalproex. Always consult your doctor for a change of dose regimen or an alternative drug of choice that may strictly be required.

Q. Does divalproex contain MAOI?

No, it does not contain MAOI.

Q. Does divalproex make you cause weight gain/hair loss?

Divalproex may cause these side effects. However, always consult your doctor if you experience any of these side effects.