Proguheal Tablets (Proguanil)

Precautions

• Not recommended in patients with severe kidney impairment unless prescribed by a doctor.
• Pregnant and breastfeeding women should use only under medical supervision.
• Patients with a history of severe allergic reactions to proguanil should not take this medicine.
• Always complete the full course of treatment, even if symptoms improve.
• Keep out of reach of children.

Uses

Proguheal Tablets (Proguanil) are prescribed for:

• Prevention of malaria (prophylaxis) in individuals traveling to malaria-prone regions.
• Treatment of malaria, usually in combination with other antimalarial medicines.
• Combination therapy (commonly with atovaquone or chloroquine) for enhanced effectiveness against resistant malaria strains.

Side Effects

Most side effects are mild and temporary. Common side effects include:

• Nausea, vomiting, or diarrhea
• Stomach pain
• Mouth ulcers
• Mild hair loss (rare)

Serious but rare side effects:

• Allergic reactions (rash, swelling, difficulty breathing)
• Severe mouth ulcers or sores
• Abnormal blood cell counts (rare and usually reversible)

Seek immediate medical attention if severe allergic reactions occur.

FAQs

1. Can Proguheal be used alone for malaria prevention?
Yes, but it is often combined with other antimalarial drugs to improve effectiveness against resistant malaria.

2. When should I start taking Proguheal for malaria prevention?
Typically, 1–2 days before entering a malaria-endemic area, during the stay, and for at least 7 days after leaving. Follow your doctor’s instructions.

3. Can children take Proguheal Tablets?
Yes, but dosage depends on age and body weight. Always use under pediatric supervision.

4. Is Proguheal safe in pregnancy?
It may be prescribed if the benefits outweigh the risks. Consult a healthcare provider before use.

5. What should I do if I miss a dose?
Take the missed dose as soon as you remember. If it’s nearly time for your next dose, skip the missed one. Do not double dose.

Interactions

Proguheal (Proguanil) may interact with:

• Warfarin and other anticoagulants – may increase bleeding risk.
• Atovaquone – often used together, but dose adjustments may be needed.
• Metoclopramide – may reduce absorption of proguanil.
• Other antimalarials – consult your doctor before combining.
• Alcohol – excessive intake may increase side effects such as stomach upset.