Panderm + Cream (Terbinafine + Clobetasol + Ofloxacin + Ornidazole) | Fungal Bacterial and Inflammatory Skin Conditions
Panderm + Cream combines Terbinafine, Clobetasol, Ofloxacin, and Ornidazole in a single topical formulation to effectively treat mixed fungal, bacterial, and protozoal skin infections by relieving inflammation, itching, and infection.
Product Overview
Panderm + Cream is a multi-action topical formulation designed to treat complex and mixed skin infections. It combines four active therapeutic agents—Terbinafine, Clobetasol, Ofloxacin, and Ornidazole—to provide a broad-spectrum approach to dermatological care. Panderm + Cream is a "4-in-1" combination is specifically utilized when a skin condition involves a mix of fungal, bacterial, and protozoal pathogens accompanied by severe inflammation and itching. By simultaneously targeting the infectious agents and the body's inflammatory response, Panderm + Cream ensures rapid symptomatic relief while effectively clearing the underlying causes of the infection.
Product Composition
- Terbinafine Hydrochloride (1.0% w/v): A potent antifungal that kills a wide range of skin fungi.
- Clobetasol Propionate (0.05% w/v): A super-high potency corticosteroid for intense anti-inflammatory action.
- Ofloxacin (0.75% w/v): A fluoroquinolone antibiotic that eliminates various Gram-positive and Gram-negative bacteria.
- Ornidazole (2.0% w/v): An antiprotozoal and antibacterial agent effective against anaerobic bacteria and certain parasites.
- Formulation: Smooth, white emollient cream for topical application.
Product Specifications
| Feature | Description |
| Therapeutic Class | Multi-component Anti-infective & Anti-inflammatory |
| Route of Administration | Topical (External) |
| Potency Level | Very High (due to Clobetasol) |
| Target Pathogens | Bacteria, Fungi, Protozoa, and Anaerobes |
| Primary Indication | Mixed or complicated skin infections |
Mechanism of Action
- Antifungal (Terbinafine): Inhibits squalene epoxidase, leading to ergosterol deficiency and a toxic buildup of squalene within the fungal cell, causing cell death.
- Anti-inflammatory (Clobetasol): Suppresses the release of inflammatory mediators (prostaglandins and leukotrienes) and inhibits the migration of white blood cells to reduce swelling and itching.
- Antibacterial (Ofloxacin): Blocks bacterial DNA gyrase and topoisomerase IV, preventing the bacteria from replicating or repairing their DNA.
- Antiprotozoal (Ornidazole): Disrupts the DNA structure of anaerobic bacteria and protozoa, leading to a loss of helical structure and strand breakage.
Key Benefits
- Broadest Protection: Simultaneously addresses fungal, bacterial, and parasitic components of a single infection.
- Rapid Symptom Control: High-potency steroid component provides immediate relief from the "itch-scratch" cycle and intense redness.
- Treatment of Resistant Cases: Effective for stubborn infections that have not responded to single-agent antifungal or antibacterial creams.
- Synergistic Action: The combination prevents the "secondary" infections that often occur when skin is broken or irritated by a primary fungal or bacterial issue.
- Convenient Single Application: Eliminates the need for multiple separate creams, improving user compliance and treatment accuracy.
Precautions
General Precautions
| Aspect | Precaution |
|---|---|
| External Use Only | Apply only on affected skin; avoid contact with eyes, mouth, and mucous membranes |
| Strong Steroid Content | Contains Clobetasol—use strictly under medical supervision |
| Infection Type | Use only for confirmed mixed infections (fungal + bacterial + inflammation) |
| Broken Skin | Avoid prolonged use on open wounds unless directed by a doctor |
| Duration | Do not use for extended periods due to risk of steroid-related side effects |
Key Safety Guidelines
- Apply a thin layer only on the affected area as prescribed
- Do not use on face, groin, or underarms unless specifically advised
- Avoid using with other steroid creams to prevent overexposure
- Wash hands before and after application
- Do not cover with airtight dressings unless instructed by a doctor
- Store in a cool, dry place away from sunlight
- Keep out of reach of children
Important Note
- Discontinue use if severe irritation, skin thinning, or allergic reaction occurs
- Consult a doctor if symptoms do not improve or worsen
- Prolonged or unsupervised use may lead to fungal resistance, skin damage, or steroid complications
Usage
Usage Guidelines
| Step | Instruction |
| Cleaning | Wash the affected skin area with a mild cleanser and pat it completely dry. |
| Application | Apply a thin film of the cream to the affected area and the immediate surrounding skin. |
| Massage | Gently massage the cream into the skin until it is evenly distributed and absorbed. |
| Hand Hygiene | Wash your hands thoroughly before and after application to prevent cross-contamination. |
| Protection | Keep the treated area open to the air; do not use tight bandages unless directed. |
Dosage & Administration
Panderm + Cream is a high-potency medication and should be used with the following precautions:
Apply the cream once or twice daily, or as specifically directed by a healthcare professional.
The duration of treatment should be kept to the shortest time necessary to clear the infection, typically not exceeding 2 weeks.
Do not use this cream on the face, groin, or underarms for extended periods due to the high potency of the corticosteroid component.
Avoid contact with the eyes, nose, and mouth; if accidental contact occurs, rinse immediately with plenty of water.
If irritation or a localized rash develops, or if the infection does not improve within 7 days, discontinue use and seek advice.
Because it contains a super-potent steroid, do not use this cream on large areas of the body or under occlusive (air-tight) dressings.
This medication is intended for external use only and should not be used for ophthalmic or intravaginal purposes.
Uses
Mixed Skin Infections: Effectively treats complex dermatological conditions involving a combination of fungi, bacteria, and protozoal pathogens.
Severe Inflammatory Dermatoses: Manages skin disorders complicated by infection that manifest with extreme redness, swelling, and scaling.
Refractory Tinea Infections: Addresses stubborn fungal infections (like ringworm or athlete’s foot) that have become secondarily infected due to scratching.
Infected Eczema and Dermatitis: Alleviates the symptoms of eczema or psoriasis when the skin barrier is compromised and colonized by bacteria or yeast.
Intertriginous Infections: Treats infections occurring in skin folds (axilla, groin, or under-breast) where heat and moisture promote mixed microbial growth.
Side effects
Common Side Effects
- Burning or stinging sensation at the application site
- Skin irritation or redness
- Itching or dryness
- Mild peeling of skin
Less Common Side Effects
- Skin thinning with prolonged use (due to Clobetasol)
- Increased hair growth at application site
- Acne-like eruptions or folliculitis
- Delayed wound healing
- Increased skin sensitivity
Rare Side Effects
| Rare Side Effect | Description |
|---|---|
| Severe Skin Atrophy | Marked thinning of skin with long-term or excessive use |
| Hypopigmentation | Lightening of skin in the treated area |
| Allergic Reaction | Rash, swelling, or severe itching due to hypersensitivity |
| Systemic Absorption Effects | Rare hormonal effects (Cushing-like symptoms) if overused |
| Worsening Infection | Masking or spread of infection due to steroid component |
Safety Note
- Discontinue use if severe irritation, skin thinning, or allergic reaction occurs
- Avoid long-term use unless prescribed by a doctor
- Consult a healthcare professional if symptoms persist or worsen
- Use only for the prescribed duration due to strong steroid and combination antibiotic content
FAQs
Q: What is Panderm + Cream used for?
A: Panderm + Cream is used for the treatment of complex mixed skin infections involving fungal, bacterial, and protozoal organisms alongside inflammatory skin reactions.
Q: How does each ingredient in Panderm + Cream work?
A: Terbinafine inhibits the enzyme Squalene Epoxidase, disrupting Ergosterol synthesis and destroying fungal cell membranes. Clobetasol binds to glucocorticoid receptors and suppresses inflammatory mediators to reduce redness, swelling, and itching. Ofloxacin inhibits bacterial DNA gyrase and topoisomerase enzymes, preventing bacterial replication and eliminating infection. Ornidazole disrupts the DNA of anaerobic bacteria and protozoa, leading to their death and elimination from the affected area.
Q: How should I apply Panderm + Cream?
A: Clean and dry the affected area thoroughly before application. Apply a thin layer of Panderm + Cream to the affected skin and surrounding area once or twice daily as prescribed by your dermatologist. Avoid applying on the face, groin, or underarm areas unless specifically directed. Wash hands thoroughly before and after application.
Q: How long should I use Panderm + Cream?
A: Panderm + Cream should be used strictly for the duration prescribed by your dermatologist, generally for a short-term period of 1 to 2 weeks. Prolonged use of this cream, particularly due to the Clobetasol content, can lead to serious skin complications including skin atrophy, stretch marks, and systemic corticosteroid side effects.
Q: Can Panderm + Cream cause skin thinning?
A: Yes, prolonged or excessive use of Panderm + Cream can cause skin thinning, also known as skin atrophy, due to its super-potent Clobetasol content. To minimise this risk, use the cream strictly for the shortest duration and minimum frequency prescribed by your dermatologist and avoid applying it on delicate or sensitive skin areas.
Q: Can Panderm + Cream be used on the face?
A: Panderm + Cream is generally not recommended for use on the face. The facial skin is thinner and more sensitive and the super-potent corticosteroid Clobetasol can cause serious side effects on facial skin including skin thinning, rosacea, perioral dermatitis, and steroid-induced acne with even short-term use. Consult your dermatologist for a safer alternative for facial skin conditions.
Q: Can Panderm + Cream cause antibiotic resistance?
A: Prolonged or unsupervised use of Panderm + Cream may contribute to antibiotic resistance due to its Ofloxacin and Ornidazole content. Always use Panderm + Cream strictly for the duration and frequency prescribed by your dermatologist and avoid self-medicating or extending the treatment course without proper medical guidance.
Q: Can Panderm + Cream be used for fungal infections alone?
A: Panderm + Cream is specifically formulated for complex mixed skin infections involving fungal, bacterial, and protozoal organisms alongside inflammation. It is not recommended as a standalone treatment for pure uncomplicated fungal infections as the corticosteroid component may suppress the immune response and potentially worsen uncomplicated fungal conditions over time.
Q: What are the common side effects of Panderm + Cream?
A: Common side effects include mild burning, stinging, itching, and skin irritation at the application site. Prolonged use may cause skin thinning, stretch marks, increased hair growth, skin discolouration, and acneiform eruptions due to the Clobetasol content. If you experience any persistent or severe side effects, discontinue use and consult your dermatologist promptly.
Q: Can Panderm + Cream cause systemic side effects?
A: Prolonged use of Panderm + Cream over large skin areas may lead to significant systemic absorption of Clobetasol, resulting in adrenal suppression and Cushing syndrome. Always use the minimum effective amount for the shortest duration necessary and follow your dermatologist's guidance strictly to minimise the risk of systemic corticosteroid side effects.
Q: Is Panderm + Cream safe for children?
A: Panderm + Cream should be used with extreme caution in children and only under strict medical supervision. Children are more susceptible to systemic absorption of topical corticosteroids and the risk of steroid-related side effects is significantly higher in younger patients. Always consult a paediatrician or dermatologist before using Panderm + Cream on children.
Q: Is Panderm + Cream safe during pregnancy and breastfeeding?
A: Panderm + Cream is not recommended during pregnancy or breastfeeding. Super-potent topical corticosteroids such as Clobetasol may cause harm to the developing foetus and certain antibiotic ingredients may not be safe during lactation.
Interactions
Topical Product Interactions
- Avoid using with other corticosteroid creams or ointments (e.g., clobetasol, betamethasone) to prevent increased risk of skin thinning and side effects
- Do not combine with other antifungal or antibacterial creams unless prescribed, as duplication may increase irritation
- Avoid using with harsh acne treatments like retinoids or benzoyl peroxide on the same area due to increased dryness and irritation
- Limit use with alcohol-based skincare products that may worsen skin sensitivity
Medication Interactions
| Medication / Class | Interaction Effect |
|---|---|
| Other Topical Steroids | Increased risk of skin thinning, irritation, and systemic absorption |
| Oral or Topical Antibiotics | Generally safe but should be used only if prescribed together |
| Strong Antifungal Agents | May overlap therapy and increase irritation without added benefit |
| Immunosuppressants | Possible additive immunosuppressive effects if absorbed systemically |
Lifestyle and Usage Interactions
- Avoid prolonged use on large areas of skin to reduce systemic absorption
- Do not use under occlusive dressings unless directed by a healthcare professional
- Maintain proper hygiene and keep the affected area clean and dry
- Avoid self-mixing multiple medicated creams without medical guidance
Important Notes
- Inform your doctor about all medications and skincare products you are using
- Use strictly for prescribed duration to prevent resistance and side effects
- Discontinue use and seek medical advice if irritation, worsening infection, or allergic reaction occurs
| Manufacturer | : | Macleods Pharma, India |
| Trade Name | : | |
| Generic Search | : | Terbinafine + Ofloxacin + Clobetasol |
| Strength | : | 15gm |
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