Panderm ++ Cream (Clobetasol + Miconazole + Neomycin) | Used to Treat Fungal Skin Infections with Bacterial Infection and Inflammation
Panderm ++ Cream is a topical antifungal, antibacterial, and anti-inflammatory medicine used to treat skin infections caused by fungi, bacteria, or inflammation. It helps relieve itching, redness, swelling, and irritation associated with various skin conditions.
Product Overview
Panderm ++ Cream is a high-potency, broad-spectrum topical combination designed for the management of complex skin infections characterized by both inflammation and microbial involvement. By integrating a potent corticosteroid, a broad-spectrum antifungal, and an aminoglycoside antibiotic, this formula provides a comprehensive solution for skin conditions where inflammation is complicated by secondary bacterial or fungal colonization.
Product Composition
- Clobetasol Propionate 0.05 percent w/w
- Miconazole Nitrate 2.0 percent w/w
- Neomycin Sulphate 0.5 percent w/w
- Cream base q.s.
Product Specification
| Feature | Details |
| Brand Name | Panderm ++ Cream |
| Therapeutic Category | Topical Corticosteroid + Antifungal + Antibiotic |
| Form | Topical Cream |
| Primary Indication | Inflammatory skin infections with fungal/bacterial components |
| Storage Requirements | Store in a cool, dry place; do not freeze |
Mechanism of Action
- Clobetasol Propionate: A super-potent corticosteroid that provides rapid relief from inflammation, redness, itching, and swelling by suppressing the immune response at the site of application.
- Miconazole Nitrate: An antifungal agent that inhibits the synthesis of ergosterol, a vital component of fungal cell membranes, leading to the inhibition of growth and destruction of fungi and yeasts.
- Neomycin Sulphate: An aminoglycoside antibiotic that interferes with bacterial protein synthesis, effectively eliminating susceptible bacteria often responsible for secondary infections in damaged skin.
Key Benefits
- Offers a multi-targeted approach to treating complex, infected skin lesions
- Provides rapid reduction of painful or uncomfortable inflammatory symptoms
- Effectively clears fungal and yeast overgrowth
- Protects against and treats secondary bacterial infections
- Simplifies the treatment regimen for mixed dermatological infections
Precautions
Use Only Under Medical Supervision
- Panderm Cream ++ contains a potent combination of clobetasol, miconazole, and neomycin and should be used only if prescribed by a doctor
- Do not use for longer duration than recommended
Avoid Prolonged Use
- Long term use of clobetasol may cause skin thinning and other steroid related side effects
- Follow prescribed treatment duration strictly
External Use Only
- Apply only on affected skin areas
- Avoid contact with eyes, mouth, and broken or sensitive skin
Avoid Occlusive Dressings
- Do not cover treated area with tight bandages unless advised by a doctor
- This may increase absorption and side effects
Monitor for Allergic Reactions
- Watch for signs like increased redness, itching, or swelling
- Discontinue use and consult a doctor if severe reaction occurs
Special Populations
- Use with caution during pregnancy and breastfeeding
- Pediatric use should be strictly supervised
| Precaution Area | Guidance |
|---|---|
| Usage | Use only as prescribed by doctor |
| Duration | Do not use for long term without supervision |
| Application | Apply thin layer on affected area only |
| Sensitive Areas | Avoid eyes, mouth, and broken skin |
| Dressings | Avoid occlusive bandaging unless advised |
| Special Cases | Use cautiously in pregnancy and children |
Usage
Dosage & Application
Apply a thin layer of the cream to the affected area only as directed by your physician
Use the medication strictly for the duration prescribed; do not extend treatment without professional approval
Apply the cream gently and sparingly; avoid excessive application, as more is not better and can increase the risk of side effects
Wash your hands thoroughly after application to prevent accidental transfer to other areas or the eyes
Important Precautions
For external use only. Do not ingest or apply to the eyes, mouth, or mucous membranes
Do not use an occlusive dressing (tight bandages or plastic wraps) over the treated area unless specifically instructed by your doctor
Avoid applying this cream to open wounds, ulcerated skin, or large surface areas without clinical oversight
If you experience any signs of skin thinning, burning, stinging, or redness, discontinue use and consult your doctor immediately
Treatment Application Table
| Procedure | Guideline |
| Frequency | Usually 1–2 times daily, as instructed |
| Technique | Apply a thin, even layer to the affected site |
| Hygiene | Clean and dry the area before application |
| Restriction | Avoid use on the face, groin, or underarms unless directed |
Uses
Management of inflammatory dermatoses complicated by secondary fungal or bacterial infections
Relief of intense pruritus (itching) and inflammation associated with eczematous conditions
Treatment of dermatophyte infections involving secondary bacterial colonization
Rapid reduction of localized erythema, swelling, and discomfort in infected skin sites
Comprehensive care for mixed microbial skin disorders requiring concurrent anti-inflammatory and anti-infective action
Side Effects
Common Skin Reactions
- Burning or stinging sensation at application site
- Redness, itching, or irritation
- Dryness or peeling of skin
Steroid Related Effects (Clobetasol)
- Skin thinning with prolonged use
- Stretch marks or visible blood vessels
- Delayed wound healing in treated area
Antibiotic Related Effects (Neomycin)
- Allergic skin reactions such as rash or contact dermatitis
- Increased sensitivity on repeated use
Fungal Treatment Effects (Miconazole)
- Mild irritation or discomfort initially
- Rare allergic reactions
Serious but Uncommon Effects
- Severe skin irritation or swelling
- Secondary infections due to prolonged steroid use
- Hypersensitivity reactions
| Side Effect Type | Details |
|---|---|
| Common Effects | Burning, itching, redness |
| Steroid Effects | Skin thinning, stretch marks |
| Antibiotic Effects | Allergic rash, sensitivity |
| Antifungal Effects | Mild irritation |
| Serious Effects | Severe allergy, secondary infection |
FAQs
Q: What is Panderm ++ Cream used for?
A: Panderm ++ Cream is used for the topical treatment of inflammatory skin conditions that are complicated by fungal or bacterial infections. It helps to reduce symptoms like redness, itching, and swelling while simultaneously fighting the underlying infection.
Q: Can I use this cream on my face?
A: Topical corticosteroids like Clobetasol are generally very potent. You should only apply this to the face if specifically instructed by a dermatologist, and for the shortest duration possible, as it may cause skin thinning or other side effects if used improperly on delicate facial skin.
Q: How long should I use this cream?
A: This cream should be used only for the duration specified by your doctor. Due to the presence of a potent corticosteroid, prolonged or continuous use should be avoided to prevent systemic absorption or adverse dermatological effects.
Q: Can I apply this under a bandage or airtight dressing?
A: You should avoid covering the area with airtight bandages or dressings (occlusive dressing) unless specifically directed by your doctor. Doing so can significantly increase the absorption of the medication into the bloodstream, which may lead to unwanted side effects.
Q: Is it safe for children?
A: The use of high-potency corticosteroids in children requires extreme caution and should only be done under strict medical supervision, as children have a higher risk of systemic absorption and potential impact on growth.
Q: What should I do if my skin condition does not improve?
A: If there is no significant improvement after several days of treatment, or if the condition worsens, stop using the cream and consult your healthcare provider immediately.
Interactions
Other Topical Steroid or Antifungal Products
- Avoid using other steroid, antifungal, or antibiotic creams at the same time
- May increase risk of skin thinning, irritation, or reduced effectiveness
Harsh Skin Care Products
- Do not use alcohol-based toners, scrubs, or strong exfoliating agents
- These may worsen irritation and damage skin barrier
Other Antibiotics (Topical or Oral)
- Concurrent use with other antibiotics should only be done under medical advice
- May increase risk of side effects or resistance
Occlusive Dressings and Bandages
- Avoid covering the treated area tightly unless prescribed
- Can increase absorption of clobetasol and risk of side effects
Vaccines and Immune Response
- Prolonged steroid use may slightly affect immune response
- Inform doctor if undergoing vaccination
| Interaction Type | Recommendation |
|---|---|
| Other Steroid Creams | Avoid combination unless prescribed |
| Antifungal/Antibiotic Creams | Use only under medical supervision |
| Harsh Skincare Products | Do not use scrubs or alcohol-based products |
| Occlusive Dressings | Avoid unless advised |
| Vaccination | Inform doctor before use |
| Manufacturer | : | Macleods Pharma, India |
| Trade Name | : | |
| Generic Search | : | Clobetasol + Miconazole+ Neomycin |
| Strength | : | 15g |




















