Folitrax Injection (Methotrexate)
Folitrax Injection contains Methotrexate, a disease-modifying antirheumatic drug (DMARD). It is primarily used to manage certain autoimmune diseases and cancers. Folitrax is typically prescribed by specialists for patients with rheumatoid arthritis, psoriasis, and some types of cancer, when oral treatment is inadequate or unsuitable.
Folitrax Injection is a sterile, preservative-free solution of Methotrexate, available in various strengths.
Methotrexate works by inhibiting dihydrofolate reductase, blocking DNA synthesis in rapidly dividing cells and modulating immune activity—making it effective against autoimmune diseases and some cancers.
Precautions of Folitrax Injection:
- Not for use during pregnancy or breastfeeding – may cause birth defects.
- Contraindicated in patients with:
- Severe liver or kidney impairment
- Blood disorders (e.g., bone marrow hypoplasia, leukopenia, thrombocytopenia)
- Active serious infections
- Should not be used if there is excessive alcohol consumption or known hypersensitivity to Methotrexate.
- Use with caution in elderly patients or those with lung disease.
Patients must have regular blood counts, liver and kidney function tests during treatment.
Uses of Folitrax Injection:
Folitrax Injection is used to treat:
- Rheumatoid arthritis: to reduce joint inflammation and slow disease progression.
- Psoriasis: especially severe, recalcitrant, disabling psoriasis that doesn't respond to other treatments.
- Certain cancers: such as acute lymphoblastic leukemia (ALL), choriocarcinoma, and non-Hodgkin’s lymphoma, often as part of combination chemotherapy.
Side Effects of Folitrax Injection:
Side effects vary by dose, duration, and patient condition.
Common side effects:
- Nausea, vomiting
- Mouth ulcers
- Loss of appetite
- Fatigue
Serious side effects (seek medical help immediately):
- Bone marrow suppression (leading to low white/red cells or platelets)
- Liver toxicity (elevated liver enzymes, hepatitis, fibrosis)
- Lung toxicity (pneumonitis, shortness of breath)
- Severe skin reactions
- Kidney problems
Regular medical monitoring helps manage these risks.
FAQs of Folitrax Injection:
Q: How is Folitrax Injection given?
A: It is usually administered by a healthcare professional via intramuscular, intravenous, or subcutaneous injection, depending on the indication.
Q: Can Folitrax cure rheumatoid arthritis or cancer?
A: It is not a cure but helps control symptoms or slow disease progression.
Q: Is regular monitoring necessary?
A: Yes. Regular blood tests and liver/kidney function tests are critical to ensure safety.
Q: What should I do if I miss a dose?
A: Contact your healthcare provider. Do not double the next dose without medical advice.
Q: Can I take supplements while on Folitrax?
A: Some supplements, especially folic acid, may be recommended to reduce side effects, but always consult your doctor.
Interactions of Folitrax Injection:
Methotrexate can interact with:
- NSAIDs (e.g., ibuprofen, naproxen): may increase toxicity
- Antibiotics (e.g., penicillins, sulfonamides): may reduce Methotrexate clearance
- Live vaccines: avoid during treatment
- Other folate antagonists: additive toxicity
- Alcohol: increases risk of liver damage
Always inform your doctor about all medications and supplements you are taking.
| Manufacturer | : | Icpa Health Products Ltd |
| Trade Name | : | Folitrax |
| Generic Search | : | Methotrexate |
| Strength | : | 7.5mg , 15mg |
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