En-clofert 50 mg (Enclomiphene Citrate) Tablets – Restore Testosterone Levels in Men
Enclomiphene (Brand: En-clofert 50 mg) is a selective estrogen receptor modulator (SERM) that stimulates the body's natural production of reproductive hormones. It is primarily used to treat secondary hypogonadism in men by restoring healthy testosterone levels while preserving fertility. Under medical supervision, it may also be prescribed to help induce ovulation in women with certain ovulatory disorders or infertility. Treatment should always be guided by a qualified healthcare professional.
Product Overview
En-clofert 50 mg is a specialized pharmacological treatment containing Enclomiphene Citrate, a non-steroidal selective estrogen receptor modulator (SERM). Unlike traditional testosterone replacement therapies (TRT), which supply external testosterone, En-clofert stimulates the body's natural hormone production by regulating the hypothalamic-pituitary-gonadal (HPG) axis.
It is primarily prescribed for men with secondary hypogonadism to restore healthy testosterone levels while preserving fertility. Under specialist supervision, Enclomiphene may also be used in women with ovulatory disorders or certain forms of infertility to stimulate ovulation. Under specialist supervision, En-clofert (Enclomiphene) may be prescribed for ovulation induction in selected women with ovulatory disorders or infertility, depending on local clinical practice and regulatory approval.
Product Composition
- Active Ingredient: Enclomiphene Citrate (50 mg).
- Formulation: Oral Tablet.
- Pharmacological Class: Selective Estrogen Receptor Modulator (SERM) / Estrogen Antagonist.
- Mechanism: Antagonism of estrogen receptors in the pituitary gland.
Product Specifications
| Feature | Details |
| Generic Name | Enclomiphene Citrate Tablets |
| Therapeutic Category | Hormone Restorative Therapy / Antiestrogen/SERM |
| Primary Indication | Secondary Hypogonadism (Low Testosterone), Ovulatory Dysfunction/Female Infertility (where prescribed by a specialist) |
| Dosing Schedule | Once daily (as directed by a physician) |
| Storage | Store at room temperature (20°C to 25°C); protect from light |
Mechanism of Action
En-clofert 50 mg works by optimizing the signaling pathway of the Hypothalamic-Pituitary-Gonadal (HPG) axis:
- Estrogen Receptor Blockade: Enclomiphene binds to and blocks estrogen receptors in the hypothalamus and pituitary gland.
- Interruption of Negative Feedback: Blocking these receptors causes the brain to perceive lower estrogen activity. As a result, the pituitary gland increases the release of reproductive hormones.
- Increased FSH and LH Production: The pituitary secretes higher levels of Follicle-Stimulating Hormone (FSH) and Luteinizing Hormone (LH).
- In men, LH stimulates the Leydig cells of the testes to increase natural testosterone production, while FSH supports sperm production.
- In women, increased FSH and LH stimulate ovarian follicle development and maturation, encouraging the ovaries to release a mature egg (ovulation). This mechanism may help women experiencing ovulatory infertility under appropriate medical supervision.
Hormonal Balance
Rather than supplying hormones externally, Enclomiphene stimulates the body's own hormonal pathways, helping restore normal endocrine function.
Key Benefits of Enclomiphene (En-clofert Tablet)
For Men
- Stimulates natural testosterone production without suppressing the body's hormonal axis.
- Helps preserve fertility by supporting sperm production.
- Improves energy, mood, libido, and overall well-being.
- Supports lean muscle mass, bone health, and physical performance.
- Convenient oral tablet taken once daily.
- Helps maintain a healthier testosterone-to-estrogen balance.
For Women (When Prescribed by a Specialist)
- May help induce ovulation in women with ovulatory dysfunction.
- Supports follicular development through increased FSH and LH secretion.
- May improve the chances of conception in selected women experiencing infertility related to irregular or absent ovulation.
- Provides a non-hormonal approach by stimulating the body's own reproductive hormone production rather than supplying external hormones.
Precautions
General Safety Guidelines
- Use En-clofert 50 mg (Enclomiphene Citrate) exactly as prescribed by your healthcare provider.
- For men, it is commonly prescribed for secondary hypogonadism and low testosterone.
- In women, it should only be used under specialist supervision for appropriate fertility or ovulation-related indications.
- Take the tablet at the same time each day for consistent results.
- Do not change the dose or stop treatment without consulting your doctor.
Allergy and Sensitivity
- Do not use if you are allergic to Enclomiphene Citrate or any ingredient in the tablet.
- Stop taking the medication and seek medical attention if you experience rash, itching, swelling of the face or throat, or difficulty breathing.
Use in Special Populations
- Not recommended for children.
- Women who are pregnant or breastfeeding should not use En-clofert unless specifically directed by their healthcare provider.
- Women using En-clofert for ovulation induction should do so only under the supervision of a fertility specialist.
- Men with heart, liver, kidney, or prostate conditions should inform their healthcare provider before starting treatment.
- Inform your doctor if you are planning fertility treatment or actively trying to conceive.
Health and Medical Considerations
| Condition | Precautions |
|---|---|
| Liver disease | Monitor liver function regularly during therapy |
| Kidney disease | Use with caution and under medical supervision |
| Heart disease | Monitor cardiovascular health during treatment. |
| Prostate disorders (Men) | Consult your doctor before use, as hormone changes may affect existing prostate conditions. |
| Blood clotting disorders | Use cautiously if you have a history of thrombosis or clotting disorders. |
| Ovarian disorders (women) | Women with ovarian cysts (other than those related to PCOS) or unexplained vaginal bleeding should consult a specialist before use. |
Drug and Lifestyle Considerations
- Inform your doctor about all prescription medications, over-the-counter medicines, vitamins, herbal supplements, hormone therapies, or fertility medications you are taking.
- Limit alcohol consumption and avoid smoking, as both may affect hormonal balance and overall treatment outcomes.
- Maintain a healthy diet, regular physical activity, and appropriate body weight to support treatment effectiveness.
Administration and Storage Guidelines
- Swallow the tablet whole with water, preferably at the same time each day.
- Store at room temperature in a cool, dry place away from moisture and direct sunlight.
- Keep out of reach of children.
- Do not use expired tablets.
Usage
To maximize the effectiveness of En-clofert 50 mg, it should be used only under the supervision of a qualified healthcare professional experienced in hormonal or fertility management. The appropriate dosage and duration depend on the condition being treated, the patient's sex, and individual clinical response.
Dosage
The dosage varies according to the therapeutic indication.
For men with secondary hypogonadism, treatment commonly involves one tablet daily, although some patients may benefit from lower doses or alternate-day dosing based on hormone levels and clinical response.
For women with ovulatory disorders or infertility, dosage schedules differ from those used in men and should be determined by a fertility specialist according to the treatment protocol.
Timing of Administration
Take the tablet at approximately the same time each day, with or without food, unless otherwise directed by your healthcare provider.
Method of Administration
Swallow the tablet whole with a glass of water. Do not crush, chew, or break the tablet unless advised by your physician.
Hormonal Monitoring
Regular medical follow-up is recommended throughout treatment.
Men may require periodic monitoring of Total Testosterone, Free Testosterone, Estradiol, LH, and FSH to optimize therapy.
Women undergoing fertility treatment may require hormonal blood tests together with ultrasound monitoring of ovarian follicle development to assess ovulation and minimize the risk of ovarian overstimulation.
Duration of Therapy
Treatment duration varies depending on the medical condition and therapeutic goals.
Men may require short-term treatment to restore hormonal balance or longer-term therapy under medical supervision.
Women generally receive treatment in defined menstrual cycles based on ovulation response and fertility planning.
Application Guidelines
Avoid Overuse
Do not exceed the prescribed dose. Taking more than recommended does not improve treatment outcomes and may increase the risk of adverse effects.
Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose. Do not take two doses together.
Storage
Store the tablets in their original packaging at room temperature (20°C–25°C) in a cool, dry place away from direct sunlight and moisture.
Vision Changes
If you experience blurred vision, flashes of light, floaters, or other persistent visual disturbances, discontinue the medication and seek medical advice promptly.
Uses
En-clofert 50 mg (Enclomiphene Citrate) is a Selective Estrogen Receptor Modulator (SERM) that stimulates the body's natural production of reproductive hormones by increasing the release of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH).
In Men
Treatment of secondary hypogonadism.
Restores natural testosterone production without suppressing the Hypothalamic-Pituitary-Gonadal (HPG) axis.
Helps preserve male fertility by supporting sperm production.
May improve sperm count and motility in selected men with hormone-related infertility.
Helps relieve symptoms associated with low testosterone, including fatigue, reduced libido, erectile dysfunction, decreased muscle mass, and low energy.
Supports healthy body composition by maintaining an appropriate testosterone-to-estrogen balance.
In Women
May be prescribed to induce ovulation in women with ovulatory dysfunction.
Stimulates ovarian follicle development by increasing FSH and LH secretion.
May improve the likelihood of conception in appropriately selected women experiencing infertility related to irregular or absent ovulation.
Should only be used under the supervision of a fertility specialist.
Therapeutic Indications
| Condition | Primary Benefit |
|---|---|
| Secondary Hypogonadism (Men) | Restores natural testosterone production while preserving HPG axis function. |
| Male Infertility | Supports spermatogenesis through increased LH and FSH production. |
| Ovulatory Dysfunction (Women) | Stimulates follicular development and promotes ovulation under specialist supervision. |
| Female Infertility Related to Anovulation | May improve the chances of conception by inducing ovulation. |
| Fatigue & Hormone-Related Symptoms | Helps improve energy, libido, and overall well-being associated with hormonal imbalance. |
| Post-TRT Recovery (Men) | May help restore endogenous testosterone production after discontinuing testosterone replacement therapy. |
Side Effects
Like all medications, En-clofert 50 mg (Enclomiphene Citrate) may cause side effects, although not everyone experiences them. Most side effects are mild and temporary, but some may require prompt medical attention.
Common Side Effects
Headache
Nausea or mild vomiting
Dizziness or lightheadedness
Hot flashes or increased sweating
Mood changes or irritability
Fatigue
Mild abdominal discomfort
Less Common Side Effects
Breast tenderness or swelling
Changes in libido or sexual desire
Temporary blurred vision, floaters, or visual spots
Sleep disturbances
Mild increase in estrogen-related symptoms
Pelvic discomfort or ovarian enlargement in women undergoing ovulation induction
Serious Side Effects
| Serious Side Effect | Description / Recommended Action |
|---|---|
| Blood clots (Thrombosis) | Sudden pain, swelling, redness, chest pain, or shortness of breath requires immediate medical attention. |
| Liver problems | Yellowing of the skin or eyes, dark urine, severe fatigue, or persistent abdominal pain should be evaluated immediately. |
| Severe allergic reaction | Rash, hives, facial or throat swelling, or difficulty breathing requires emergency medical care. |
| Persistent vision disturbances | Blurred vision, flashes of light, floaters, or eye pain should be reported immediately and treatment discontinued until evaluated. |
| Ovarian enlargement or severe pelvic pain (Women) | Severe lower abdominal pain, bloating, or rapid weight gain may indicate ovarian complications and requires prompt medical evaluation. |
| Worsening prostate symptoms (Men) | Increased difficulty urinating, painful urination, or other significant urinary symptoms should be discussed with your healthcare provider promptly. |
Important Advice
Take En-clofert 50 mg exactly as prescribed by your healthcare provider.
Do not increase or decrease your dose without medical advice.
Report any persistent, unusual, or severe symptoms immediately.
Regular monitoring of hormone levels and overall health is recommended throughout treatment.
Men may require periodic monitoring of testosterone, LH, FSH, and liver function.
Women receiving treatment for ovulation induction may require ultrasound monitoring and hormonal assessments to evaluate ovarian response and reduce the risk of complications.
Maintain a balanced diet, regular exercise, and healthy lifestyle habits to support treatment effectiveness.
Side effects may vary depending on the condition being treated, the prescribed dosage, and whether the medication is used in men or women. Your healthcare provider will determine the most appropriate monitoring plan for your treatment.
FAQs
Q: What is En-clofert 50 (Enclomiphene) mg used for?
A: En-clofert 50 mg (Enclomiphene Citrate) is primarily prescribed to treat secondary hypogonadism in men by stimulating the body's natural testosterone production. Under specialist supervision, it may also be prescribed to induce ovulation in women with certain ovulatory disorders or infertility.
Q: How does Enclomiphene differ from Testosterone Replacement Therapy (TRT)?
A: Unlike Testosterone Replacement Therapy (TRT), which supplies external testosterone and may suppress the body's natural hormone production, En-clofert stimulates the pituitary gland to produce more Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH). This helps increase natural testosterone production while preserving normal testicular function.
Q: Will En-clofert affect fertility?
A: In men, En-clofert is often chosen because it helps preserve or improve fertility by supporting sperm production through increased LH and FSH levels. In women, it may help improve fertility by stimulating ovulation in those with ovulatory dysfunction. Treatment should always be supervised by a healthcare professional.
Q: How long does it take to see results?
A: The response varies depending on the condition being treated. Men may notice improvements in testosterone levels within a few weeks, while improvements in energy, libido, and mood often occur within 4 to 6 weeks. Women receiving treatment for ovulation induction generally respond according to their menstrual cycle and physician-directed treatment schedule.
Q: What are the common side effects of En-clofert?
A: Common side effects may include headache, nausea, dizziness, hot flashes, mood changes, fatigue, or mild abdominal discomfort. Some women may experience pelvic discomfort during ovulation induction. Contact your healthcare provider if side effects become severe or persistent.
Q: Can En-clofert (Enclomiphene) be used by women?
A: Yes. Although En-clofert is primarily prescribed for men with secondary hypogonadism, it may also be used under specialist supervision to induce ovulation in women with certain fertility disorders or ovulatory dysfunction. It should not be used during pregnancy or while breastfeeding unless specifically advised by a healthcare provider.
Q: Do I need regular medical monitoring during treatment?
A: Yes. Regular monitoring helps ensure the treatment is safe and effective. Men may require blood tests to monitor testosterone, estradiol, LH, and FSH levels. Women undergoing fertility treatment may require hormone testing and ultrasound monitoring to evaluate ovarian response.
Q: Are there any vision-related concerns with this medication?
A: Although uncommon, some people taking selective estrogen receptor modulators (SERMs) may experience blurred vision, flashes of light, or floaters. If you notice persistent visual changes, stop taking the medication and contact your healthcare provider immediately.
Q: How should I take En-clofert 50 mg (Enclomiphene)?
A: Take En-clofert exactly as prescribed by your healthcare provider. The tablet may be taken with or without food, preferably at the same time each day. Dosage schedules differ depending on whether the medication is being used for male hypogonadism or female fertility treatment.
Q: Can En-clofert (Enclomiphene) treat primary hypogonadism?
A: En-clofert is generally most effective in men with secondary hypogonadism, where the brain does not produce enough LH and FSH to stimulate testosterone production. It is usually less effective in primary hypogonadism, where the testes cannot produce sufficient testosterone despite normal hormonal signaling.
Q: Can En-clofert(Enclomiphene) improve sperm count?
A: Yes. In appropriately selected men, En-clofert may improve sperm production by increasing Follicle-Stimulating Hormone (FSH) and Luteinizing Hormone (LH), making it a treatment option for some cases of hormone-related male infertility.
Q: Can En-clofert(Enclomiphene) help women with infertility?
A: In selected women with infertility caused by irregular or absent ovulation, En-clofert may stimulate follicular development and ovulation by increasing the release of FSH and LH. Treatment should only be initiated and monitored by a fertility specialist.
Interactions
Drug Interactions
| Drug / Substance | Interaction Considerations |
|---|---|
| Testosterone Replacement Therapy (TRT) | Concurrent use may alter hormone levels and reduce the need for En-clofert. Hormone levels should be monitored closely. |
| Clomiphene or other fertility medications | Using multiple fertility medications together may increase hormonal effects. Use only under specialist supervision. |
| Hormonal therapies (Estrogens or Androgens) | May influence the effectiveness of En-clofert and require dose adjustment or monitoring. |
| Blood thinners (e.g., Warfarin) | Use with caution, as hormonal changes may influence clotting in some individuals. Your healthcare provider may recommend additional monitoring. |
| Corticosteroids | May affect hormonal balance and should be used under medical supervision. |
| Medications affecting liver or kidney function | Dose adjustment or closer monitoring may be necessary, particularly in patients with impaired liver or kidney function. |
Lifestyle and Health Considerations
Limit alcohol consumption and avoid smoking, as both may negatively affect hormonal balance and treatment outcomes.
Maintain a balanced diet, healthy body weight, and regular physical activity to support reproductive and hormonal health.
Inform your healthcare provider about all prescription medications, over-the-counter medicines, vitamins, herbal supplements, and fertility treatments before starting En-clofert.
Do not start or stop any medication without consulting your healthcare provider.
Special Population Considerations
Older adults may require closer monitoring of hormone levels and treatment response.
Patients with liver, kidney, heart, or clotting disorders should use En-clofert only under medical supervision.
Women should use En-clofert only when prescribed for an appropriate fertility indication and under the supervision of a fertility specialist.
En-clofert is generally not recommended for children.
Do not use En-clofert during pregnancy or while breastfeeding unless specifically advised by your healthcare provider.
Important Advice
Take En-clofert 50 mg exactly as prescribed.
Inform your healthcare provider if you develop severe headaches, vision changes, chest pain, shortness of breath, persistent abdominal pain, severe pelvic pain, or significant mood changes.
Regular monitoring is recommended throughout treatment.
Men may require periodic evaluation of testosterone, LH, FSH, estradiol, and liver function.
Women undergoing fertility treatment may require hormone testing and ultrasound monitoring to assess ovarian response and ovulation.
Never share this medication with another person, even if they have similar symptoms.
| Manufacturer | : | Maneesh Pharma, India |
| Trade Name | : | Androxal |
| Generic Search | : | Enclomiphene |
| Strength | : | 50 mg |
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