Bonefine-Alfa Tablet (Alfacalcidol)
Bonefine-Alfa Tablet contains Alfacalcidol, a vitamin D analogue used to manage calcium and phosphate balance in the body. It is commonly prescribed for bone and mineral disorders caused by chronic kidney disease, rickets, osteomalacia, and certain hormonal imbalances.
Introduction of Bonefine-Alfa Tablet (Alfacalcidol)
Bonefine-Alfa Tablet contains Alfacalcidol, a vitamin D analogue used to help regulate calcium and phosphate balance in the body. It is primarily prescribed for people who have difficulty converting vitamin D into its active form—often due to chronic kidney disease, certain bone disorders, or hormonal imbalances. By supporting healthy calcium absorption and bone mineralization, Bonefine-Alfa plays a key role in preventing and treating conditions like soft or weak bones, low blood calcium levels, and related complications. It is intended for use under medical supervision, especially in patients whose vitamin D metabolism is impaired.
Precautions & Warnings of Bonefine-Alfa Tablet (Alfacalcidol)
Contraindications
- Allergic to alfacalcidol or excipients
- Hypercalcaemia or vitamin D toxicity (hypervitaminosis D)
- Known hypersensitivity (e.g. sesame oil in some brands)
Special Populations
- Pregnancy & breastfeeding: Safety not established; consult physician before use
- Cardiovascular disease: Monitor ECG and electrolytes due to potential for irregular heartbeat
- Renal, hepatic, or vascular disorders, sarcoidosis, kidney stones, malabsorption syndromes: Use with caution
Uses of Bonefine-Alfa Tablet (Alfacalcidol)
Bonefine-Alfa is prescribed to treat and prevent conditions related to abnormal calcium and phosphate metabolism, particularly when the body cannot adequately activate vitamin D. It is commonly used for:
- Hypocalcaemia – low calcium levels in the blood, especially in patients with chronic kidney disease.
- Renal Osteodystrophy – bone weakening caused by kidney failure.
- Secondary Hyperparathyroidism – overactivity of the parathyroid glands due to long-term low calcium or kidney disease.
- Rickets – soft bones in children caused by vitamin D or calcium deficiency.
- Osteomalacia – soft bones in adults due to poor bone mineralization.
- Osteoporosis – to help strengthen bones and reduce fracture risk in certain cases.
- Hypoparathyroidism – low parathyroid hormone levels leading to calcium imbalance.
Side Effects of Bonefine-Alfa Tablet (Alfacalcidol)
Like all medicines, Bonefine-Alfa can cause side effects, although not everyone experiences them.
Common / Mild Side Effects:
- Headache
- Nausea or vomiting
- Constipation or diarrhea
- Abdominal pain or discomfort
- Skin rash or itching
- Metallic taste in mouth
- Increased thirst or dry mouth
Serious Side Effects (Require Immediate Medical Attention):
- Hypercalcaemia (high calcium levels), which may cause:
- Weakness, fatigue, confusion
- Nausea, vomiting, constipation
- Bone or muscle pain
- Excessive urination (polyuria) or excessive thirst (polydipsia)
- Irregular heartbeat or palpitations
Frequently Asked Questions (FAQs)
Why input alfacalcidol over vitamin D₃?
Alfacalcidol bypasses renal activation, making it effective for patients with impaired kidney function.
When will I see results?
Calcium absorption begins within ~6 hours; peak at ~24 hours; full improvement may take months.
What if I miss a dose?
Take as soon as remembered unless next dose is near—do not double up.
Can I take it with food?
Yes, with or without food. Stay consistent with timing daily.
Is it safe to use daily?
Yes, under medical supervision and regular monitoring.
Can I combine with calcium supplements?
Yes, but maintain spacing (several hours) to optimize absorption and prevent hypercalcaemia.
Interactions of Bonefine-Alfa Tablet (Alfacalcidol)
- Concurrent use with cholecalciferol, calcitriol, or other vitamin D analogues can lead to excessive vitamin D activity and hypercalcaemia.
- May increase the risk of hypercalcaemia if taken without proper monitoring.
- High calcium levels caused by alfacalcidol can increase the risk of irregular heart rhythms or digitalis toxicity.
- Antiepileptic Drugs (e.g., phenytoin, phenobarbital, carbamazepine)
- It can increase the metabolism of vitamin D analogues, reducing the effect of alfacalcidol.
- May reduce the effect of alfacalcidol on calcium absorption.
- Magnesium-Containing Antacids or Laxatives
- Can cause high magnesium levels, especially in patients with kidney problems.
| Manufacturer | : | Healing Pharma |
| Trade Name | : | |
| Generic Search | : | Alfacalcidol |
| Strength | : | 0.25 mg |
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