Temonat Capsule (Temozolomide)

Introduction of Temonat Capsule (Temozolomide)

Temonat (temozolomide) interferes with the development of cancer cells, slowing their growth and spread in the body. Temonat is used together with radiation therapy to treat certain types of brain tumors in adults. Temonat is usually given after other cancer medicines have been tried without success. Temozolomide is an antitumor drug and belongs to a class of medications called alkylating agents. It works by slowing or stopping the growth of cancer cells in the body. Temodar is another brand name for Temozolomide.

Uses of Temonat Capsule (Temozolomide)

Temozolomide is used in adults and in children above 3 years of age to treat certain specific types of brain tumors such as glioblastoma multiforme (malignant grade IV brain tumor) or anaplastic astrocytoma (grade III brain tumor). It is usually used together with radiotherapy or other medications and is generally given after other cancer medicines have been tried without success.
You should not take Temonat if you are allergic to temozolomide or to another cancer medication called dacarbazine (DTIC-Dome). Before taking Temonat, tell your doctor if you have liver or kidney disease. Do not use Temonat if you are pregnant. It could harm the unborn baby. Do not open a capsule, or use a pill that has been accidentally broken. The medicine from a crushed or broken pill can be dangerous if you accidentally inhale it, or if it gets in your eyes, mouth, or nose, or on your skin. If this occurs, wash your skin with soap and water or rinse your eyes with water. Ask your doctor or pharmacist how to safely handle and dispose of a broken tablet or capsule. Temonat is often given together with radiation treatment and then continued for several weeks or months after radiation treatment ends. There may be periods of time when you will take Temonat for only a few days in a row and then wait for another 2 to 4 weeks before you start a new treatment cycle and take it again. Follow your doctor's instructions carefully. Your doctor may occasionally change your dose to make sure you get the best results. The size, color, and number of Temonat capsules you take may be different from time to time as your doctor adjusts your dose. Be sure you know the correct number of capsules to take and on which days to take them. Contact your doctor or pharmacist if you have any questions. Taking temozolomide/Temodar may increase your risk of developing certain types of bone marrow cancer. Talk with your doctor about your individual risk.

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Side effects of Temonat Capsule (Temozolomide)

Get emergency medical help if you have any signs of an allergic reaction to Temonat: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: a seizure (convulsions); fever, chills, dry cough, feeling short of breath; easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin; low white blood cell counts - fever, swollen gums, painful mouth sores, pain when swallowing, skin sores, cold or flu symptoms, cough, trouble breathing; or liver problems - nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). Common Temonat side effects may include bruising, skin rash; loss of movement on one side of the body; nausea, vomiting, loss of appetite; diarrhea, constipation; headache, tired feeling, memory problems; dizziness, weakness, loss of coordination; sleep problems (insomnia); low white blood cell counts (fever, flu symptoms); or hair loss. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

Precautions of Temonat Capsule (Temozolomide)

You should not take Temonat if you are allergic to temozolomide or to another cancer medication called dacarbazine (DTIC). To make sure Temonat is safe for you, tell your doctor if you have: liver disease; or kidney disease. Using Temonat may increase your risk of developing certain types of bone marrow cancer. Ask your doctor about your specific risk. FDA pregnancy category D. Do not use Temonat if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment. Use birth control to prevent pregnancy while you are receiving Temonat, whether you are a man or a woman. Temozolomide use by either parent may cause birth defects. It is not known whether temozolomide/Temodar passes into breast milk or if it could harm a nursing baby. You should not breastfeed while using this medicine.

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Interaction with Temonat Capsule (Temozolomide)

Take Temonat exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. Temonat is given in a 28-day treatment cycle, and you may only need to take the medicine during the first few days of each cycle. If you are also receiving radiation treatment, you may need to take temozolomide for 6 to 7 weeks in a row during your first treatment cycle. Then you may be switched to a 28-day maintenance treatment cycle. Your doctor will determine how long to treat you with Temonat. Follow your doctor's dosing instructions very carefully. Your doctor may occasionally change your dose to make sure you get the best results. The size, color, and number of Temonat capsules you take may sometimes be different from earlier treatment cycles. Be sure you know the correct number of capsules to take and on which days to take them. Ask your doctor or pharmacist if you have any questions. Take all of your capsules for the day (one entire daily dose) at the same time on each dosing day of a treatment cycle. Swallow the capsules whole with a full glass of water. Take this medicine at the same time each day. You may need to take Temonat at bedtime or on an empty stomach if the medicine upsets your stomach. If you vomit shortly after taking the medicine, do not take another capsule until your next regularly scheduled dose.

Do not open a capsule. Do not use a broken pill. The medicine from an open or broken capsule can be dangerous if it gets in your mouth or nose, or on your skin. If this occurs, rinse thoroughly with water. Ask your doctor or pharmacist how to safely handle and dispose of a broken tablet or capsule. You may be given medication to prevent nausea or other side effects while you are receiving Temonat. Temonat can lower blood cells that help your body fight infections and help your blood clot. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. Your blood may need to be tested often. Tell your doctor if you have any changes in height or weight. Temozolomide doses are based on body surface area (height and weight), and any changes may affect your dose. Your doctor will need to check your progress while you are using this medicine. Store at room temperature away from moisture and heat.

FAQs:

What happens if I miss a dose?

Call your doctor for instructions if you miss a dose of Temonat.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Taking Temonat for more than 5 days in a row can cause a life-threatening overdose. Overdose can cause severe forms of some of the side effects listed in this medication guide.

What should I avoid while taking Temonat?

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection. Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth. This medicine can pass into body fluids (urine, feces, vomit). Caregivers should wear rubber gloves while cleaning up a patient's body fluids, handling contaminated trash or laundry, or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from another laundry.