Xovoltib Tablet (Afatinib dimaleate)

Introduction of Xovoltib Tablet (Afatinib dimaleate)

Afatinib dimaleate, sold under the brand name Xovoltib, is a medication used in the treatment of certain types of lung cancer. It belongs to the class of drugs known as tyrosine kinase inhibitors (TKIs), which work by blocking specific proteins involved in the growth and spread of cancer cells. Afatinib dimaleate is primarily prescribed for patients with non-small cell lung cancer (NSCLC) that has specific genetic mutations, such as epidermal growth factor receptor (EGFR) mutations. Gilotrif is another brand name for Afatinib dimaleate. It contains the same active ingredient and is used for the same indications as Xovoltib. Gilotrif is also prescribed for patients with EGFR mutation-positive NSCLC and is available in tablet form. The dosage and administration guidelines for Gilotrif are generally the same as Xovoltib, with the recommended starting dose of 40 mg taken orally once daily. It is important to note that the brand name of the medication may vary depending on the country and region.

Dosage Information

The recommended dosage of Afatinib dimaleate tablets (Xovoltib) may vary depending on the individual patient's condition and response to treatment. It is crucial to follow the dosage instructions provided by the prescribing healthcare professional. Generally, the starting dose for Afatinib dimaleate is 40 mg taken orally once daily, with or without food. The tablets should be swallowed whole and not crushed or chewed. If certain side effects occur, the dose may be adjusted or temporarily interrupted as deemed necessary by the healthcare provider.

Uses of Xovoltib Tablet (Afatinib dimaleate)

Afatinib dimaleate (Xovoltib) is primarily used for the treatment of advanced or metastatic NSCLC with specific EGFR mutations. It is especially beneficial for patients who have not received prior EGFR-targeted therapy or chemotherapy. By inhibiting the activity of EGFR and other related proteins, Afatinib dimaleate helps to slow down the growth and spread of cancer cells, thereby improving overall survival and progression-free survival rates in eligible patients.

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In summary, Afatinib dimaleate, marketed as Xovoltib or Gilotrif, is a tyrosine kinase inhibitor used in the treatment of certain types of lung cancer, specifically NSCLC with EGFR mutations. The recommended dosage of Afatinib dimaleate is 40 mg taken orally once daily, and it works by inhibiting the activity of EGFR and related proteins involved in cancer cell growth. The price of Afatinib dimaleate may vary, and it is advisable to check reputable sources or consult with pharmacies to obtain accurate pricing information.

Side Effects of Xovoltib Tablet (Afatinib dimaleate)

• Gastrointestinal Effects
• Skin and Nail Reactions
• Fatigue
• Respiratory Effects
• Eye Disorders
  
  

Precautions of Xovoltib Tablet (Afatinib dimaleate)

• Before starting treatment with Afatinib dimaleate, it is essential to inform your healthcare provider about any existing medical conditions, including liver or kidney problems, lung diseases, or a history of eye problems. This information will help the healthcare provider determine if Afatinib dimaleate is suitable for you and if any dose adjustments or additional monitoring are necessary.
• Afatinib dimaleate may cause severe diarrhea, which can lead to dehydration and electrolyte imbalances. It is important to promptly notify your healthcare provider if you experience persistent or severe diarrhea so that appropriate measures can be taken to manage this side effect.
• Patients taking Afatinib dimaleate should be closely monitored for any signs of interstitial lung disease (ILD) or pneumonitis, which may include symptoms such as cough, difficulty breathing, or fever. If such symptoms occur, medical attention should be sought immediately, as treatment with Afatinib dimaleate may need to be interrupted or discontinued.
• Afatinib dimaleate can cause serious skin reactions, such as rash, blistering, or peeling of the skin. If you develop any skin-related side effects, it is crucial to inform your healthcare provider right away, as they may need to adjust your treatment or provide supportive care.
• The use of Afatinib dimaleate during pregnancy or breastfeeding should be avoided unless specifically recommended by a healthcare professional. It is important to discuss the potential risks and benefits of the medication in such cases.
  
  

Drug Interactions with Xovoltib Tablet (Afatinib dimaleate)

• Afatinib dimaleate may interact with other medications, potentially affecting their efficacy or increasing the risk of side effects. Inform your healthcare provider about all the medications, supplements, or herbal products you are taking, including prescription and over-the-counter drugs, to avoid potential drug interactions.
• Afatinib dimaleate/Gilotrif may interact with medications that affect the liver enzymes responsible for metabolizing drugs, such as strong CYP3A inhibitors or inducers. This interaction can alter the blood levels of Afatinib dimaleate, leading to reduced efficacy or increased toxicity. Therefore, it is important to consult your healthcare provider before starting or stopping any medications while taking Afatinib dimaleate.
• Antacids, proton pump inhibitors (PPIs), or H2-receptor antagonists may decrease the absorption of Afatinib dimaleate. It is recommended to separate the administration of these medications from Afatinib dimaleate by several hours.
  
  

FAQs:

Xovoltib Tablet (Afatinib dimaleate)

Is Afatinib dimaleate suitable for all types of lung cancer?

No, Afatinib dimaleate is primarily used for the treatment of non-small cell lung cancer (NSCLC) that has specific genetic mutations, such as epidermal growth factor receptor (EGFR) mutations. It may not be effective for other types of lung cancer. Your healthcare provider will determine if Afatinib dimaleate is suitable for your specific condition.

How should I take Afatinib dimaleate tablets?

Afatinib dimaleate tablets should be taken orally, swallowed whole, and not crushed or chewed. The recommended dose is usually 40 mg taken once daily, with or without food. It is important to follow the dosage instructions provided by your healthcare provider.

What should I do if I miss a dose of Afatinib dimaleate/Gilotrif?

If you miss a dose of Afatinib dimaleate, take it as soon as you remember, unless it is close to the time for your next scheduled dose. Do not take a double dose to make up for a missed dose. Continue with your regular dosing schedule.

Can I drive or operate machinery while taking Afatinib dimaleate?

Afatinib dimaleate may cause side effects such as fatigue or blurred vision, which can affect your ability to drive or operate machinery. It is advisable to assess how you feel and consult your healthcare provider before engaging in activities that require alertness and clear vision. If you experience any significant side effects, it is recommended to avoid driving or operating machinery until you are certain of your abilities.